A5101610691- Bone Metabolism and Diseases
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Peroxisome Proliferator-Activated Receptors
- Circular RNAs in diseases
- Luminescence and Fluorescent Materials
- Metabolism, Diabetes, and Cancer
- Bone health and treatments
- Pancreatic function and diabetes
- Neuropeptides and Animal Physiology
- Natural product bioactivities and synthesis
- Genomics and Phylogenetic Studies
- Polydiacetylene-based materials and applications
- Catalytic Cross-Coupling Reactions
- Oral and gingival health research
- Nuclear Receptors and Signaling
- Adipose Tissue and Metabolism
- Immune Cell Function and Interaction
- Inflammasome and immune disorders
- Neurological Disease Mechanisms and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Extracellular vesicles in disease
- Antimicrobial Peptides and Activities
- Cancer Treatment and Pharmacology
- X-ray Diffraction in Crystallography
Zhongshan Hospital
2021-2024
Fudan University
2021-2024
Qingdao University
2024
Affiliated Hospital of Qingdao University
2024
Southwest University of Science and Technology
2018-2024
Fujian Medical University
2024
Union Hospital
2024
Tianjin Medical University
1997-2023
Sichuan University
2009-2023
State Key Laboratory of Biotherapy
2013-2023
The development of facile methods for screening organic functional molecules through C–H bond activation is a revolutionary trend in materials research. prediction mechanochromism as well mechanochromic trends luminogens an appealing yet challenging puzzle. Here, we present strategy the design based on dipole moment donor–acceptor molecules. For this purpose, highly efficient route to 2,7-diaryl-[1,2,4]triazolo[1,5-a]pyrimidines (2,7-diaryl-TAPs) has been established programmed arylation,...
Reciprocal relationship usually exists between osteoblastogenesis and adipogenesis, with factors stimulating one of these processes at the same time inhibiting other. In present study, miR-30e was found to be involved in reciprocal regulation osteoblast adipocyte differentiation. Our data indicated that induced primarily cultured mouse bone marrow stromal cell, mesenchymal cell line C3H10T1/2 preadipocyte 3T3-L1 after adipogenic treatment. Conversely, it reduced ST2 preosteoblast MC3T3-E1...
Triptolide possesses the trait of renal protection.Epithelial-mesenchymal transition (EMT) is closely linked to pathogenesis diabetic kidney disease (DKD).MicroRNAs have recently emerged as critical regulators DKD.However, it poorly understood whether triptolide alleviates EMT by regulating microRNAs in DKD.In this study, we found that decreased albuminuria, improved structure and reduced rats with DKD.Furthermore, activation PI3K/AKT signaling pathway was increased rats, which partly...
Excessive mitochondrial fission was observed in diabetic kidney disease (DKD). Phosphoglycerate mutase family member 5 (PGAM5) plays an important role by dephosphorylating the dynamin-related protein 1 at Ser637 (DRP1S637). Whether PGAM5 participates renal tubular injury is unknown. Clinical trials have encouraging effect of Sodium-glucose cotransporter 2 (SGLT2) inhibitors on DKD though underling mechanisms remain unclear.We used KK-Ay mice as model and Empagliflozin (Empa) were...
Many studies have shown that tissue kallikrein has effects on diabetic vascular complications such as nephropathy, cardiomyopathy and neuropathy, but its retinopathy are not fully understood. Here, we investigated the retinoprotective role of exogenous pancreatic studied potential mechanisms action. We used KK Cg-Ay/J (KKAy) mice (a mouse model spontaneous type 2 diabetes) with high-fat diet/streptozotocin (STZ)-induced diabetes our models. After onset diabetes, both types were injected...
Osteoarthritis (OA) occurs mostly in the knees, hips, finger interphalangeal joints, and spinal facet is characterized by cartilage degeneration. The existing bulk RNA sequencing (bulk RNA-seq) single-cell (scRNA-seq) data for chondrocytes osteoarthritic knee joint provide expression profiles of entire cell populations individual cells, respectively. Here, we aimed to analyze these two types order obtain a more comprehensive understanding OA. We compared analysis results RNA-seq scRNA-seq...
SUMO-activating enzyme subunit 2 (SAE2) is the sole E1-activating required for numerous important protein SUMOylation, abnormal of which associated with carcinogenesis. SAE2 inactivation was recently reported to be a therapeutic strategy in cancers Myc overexpression. However, roles small cell lung cancer (SCLC) are largely unknown. Stably knockdown H446 cells were established lentiviral system. Cell viability, cycle, and apoptosis analyzed using MTT assay flow cytometric assay. Expression...
Metformin is widely used for the treatment of type 2 diabetes mellitus. In this study, we evaluated effects metformin on osteoblast and adipocyte differentiation rat marrow mesenchymal stem cells (MSCs) in culture. Treatment MSCs osteoblastic or adipogenic medium with 100 muM 21 days led to an increased mRNA expression markers but a decreased MSCs. markedly stimulated deposition mineralized nodules blocked formation cytoplasmic lipid droplets. addition, alkaline phosphate activity Western...
The effective mechanisms of microRNAs (miRNAs) functions as oncogenes or tumour suppressors in human hepatocellular carcinoma (HCC) are still obscure. Here, we investigated the function and expression miR-1228 HCC. role HCC was determined by colony formation, transwell, nude mice xenograft experiments. target gene were identified EGFP reporter assays, real-time PCR, western blot analysis. Dual-luciferase assay PCR analysis used to examine regulation p53. promoted proliferation metastasis,...
Two efficient ruthenium sensitizers with a phenothiazine-modified bipyridine as an ancillary ligand, coded SCZ-1 and SCZ-2, have been developed dyes in dye-sensitized solar cells (DSSCs). Both exhibit low-energy metal-to-ligand charge transfer (MLCT) bands centered at 539 nm high molar extinction coefficients of 1.77 × 10(4) M(-1) cm(-1) for 1.66 which are significantly higher than the corresponding value reference N719 (1.27 cm(-1)), indicating that light-harvesting capacity can be...
A copper-catalysed oxidative C–H/N–H cross-coupling between formamides and amides through chelation-assisted N–H activation has been developed for the preparation of various multi-substituted ureas.
Background: Tigecycline, a glycylcycline antibiotic, is increasingly used clinically for the treatment of severe infections caused by multidrug-resistant bacteria, but it also associated with hepatotoxicity. However, incidence and risk factors tigecycline-associated drug-induced liver injury (DILI) are unclear. We conducted this study to investigate incidence, characteristics DILI in real-world clinic setting. Patients Methods: A retrospective analysis was inpatients who received tigecycline...
The unusual strong fluorescence of a hyperbranched molecule (3-hydroxyphenyl) phosphate (HHPP), which does not possess rigid planar structure or obvious large π system, was discovered for the first time. effects solvent polarity, pH value, concentration, and end group modification on absorption spectra HHPP solutions were investigated. terminal phenol groups triphenyl (TPP) structures in found to be responsible two peaks. greatly enhanced is explained by three factors. In particular, special...
The organization and regulation of membraneless compartments in cells remain one the fundamental questions biology 1 .How harness condensates for their well-being how pathogens hijack or counteract proliferation are elusive.Stress granules (SGs) dynamic large cytoplasmic phaseseparated mRNA-protein response to various stresses.The assembly SGs can be positively negatively regulated by many endogenous exogenous factors 2,3 .G3BP1/2 core components stress granules, which undergoes...
Abstract Lipopolysaccharide (LPS) plays an important role in bone resorption, which involves numerous cytokines through various signaling pathways. RANKL and interleukin (IL)‐6 are two that involved remodeling. The aim of this study was to evaluate the effect LPS on IL‐6 gene expression, relationship IL‐6, extracellular signal‐regulated kinases 1/2 (ERK1/2) secretion induced by MLO‐Y4 cells. cells were stimulated at different concentrations (1, 10, 100, 500, 1000 ng/mL) for durations (0.5,...
The rapid progress of sequencing technology has greatly facilitated the de novo genome assembly pig breeds. However, wild boar is still lacking, hampering our understanding chromosomal and genomic evolution during domestication from boars into domestic pigs. Here, we sequenced assembled a European (ASM2165605v1) using long-range information provided by 10× Linked-Reads sequencing. We achieved high-quality with contig N50 26.09 Mb. Additionally, 1.64% contigs (222) lengths 107.65 kb to 75.36...
In response to hyperglycemia in patients with diabetes, many signaling pathways contribute the pathogenesis of diabetic complications, including retinopathy (DR). Excessive production inflammatory mediators plays an important role this process. Amadori-glycated albumin, one major forms advanced glycated end-products, has been implicated DR by inducing responses microglia/macrophages. Our goal was delineate potential cross talk between class A scavenger receptor (SR-A) and for end-product...