A5101505890- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Genomics and Phylogenetic Studies
- Osteoarthritis Treatment and Mechanisms
- Virus-based gene therapy research
- Bone Metabolism and Diseases
- Chemokine receptors and signaling
- Cardiac Arrhythmias and Treatments
- Rheumatoid Arthritis Research and Therapies
- Inflammatory mediators and NSAID effects
- DNA and Nucleic Acid Chemistry
- Biopolymer Synthesis and Applications
- Animal Genetics and Reproduction
- Dendrimers and Hyperbranched Polymers
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Cancer Genomics and Diagnostics
- Cardiovascular Disease and Adiposity
- Nuclear Receptors and Signaling
- Marxism and Critical Theory
- Radiopharmaceutical Chemistry and Applications
- Political theory and Gramsci
- Insect Resistance and Genetics
- Sperm and Testicular Function
- Biochemical effects in animals
- ATP Synthase and ATPases Research
Jiujiang First People's Hospital
2022-2025
Sichuan University
2022-2024
University of Chicago
2014-2024
Shenzhen Institutes of Advanced Technology
2022-2023
Chinese Academy of Sciences
2022-2023
Chinese University of Hong Kong, Shenzhen
2022-2023
Southern Medical University
2011-2022
Nanfang Hospital
2011-2022
West China Hospital of Sichuan University
2022
Youjiang Medical College for Nationalities
2019-2020
Chemotherapeutic drugs frequently encounter multidrug resistance. ATP from mitochondria helps overexpression of drug efflux pumps to induce resistance, so mitochondrial delivery as a means "repurposing'' chemotherapeutic currently used in the clinic appears be worthwhile strategy pursue for development new anti-drug-resistant cancer agents. TPP-Pluronic F127-hyaluronic acid (HA) (TPH), with mitochondria-targeting triphenylphosphine (TPP) head group, was first synthesized through ester bond...
The high level of reactive oxygen species (ROS) in the rheumatoid arthritis (RA) microenvironment (RAM) and its persistent inflammatory nature can promote damage to joints, bones, synovium. Targeting strategies that integrate effective RAM regulation with imaging-based monitoring could lead improvements diagnosis treatment RA. Here, we report combined use small interfering RNAs (siRNAs T/I ) Prussian blue nanoparticles (PBNPs) silence expression proinflammatory cytokines TNF-α/IL-6 scavenge...
Abstract In addition to inhibiting persistent inflammation, phosphatase and tensin homolog deleted from chromosome 10 (PTEN) is known as an important therapeutic target for alleviating rheumatoid arthritis (RA) symptoms. Modulation of PTEN gene expression in synovial tissue using messenger RNA (mRNA) a promising approach combat RA. However, mRNA therapeutics are often hampered by unsatisfactory stability inefficient localization tissue. this study, genetically engineered biomimetic...
Objectives.The relationship of sleep to health has been an active area research in recent years, and the National Social Life, Health, Aging Project (NSHAP) expanded data collection Wave 2 with enhanced core questions a novel module that included objective measure duration quality.
The purpose of this work is to investigate how the Rho family GTPases A (RhoA) mediates pathogenesis rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS).The expression RhoA in synovial tissues RA and Healthy people (Control) was detected using immunohistochemistry methods. hypoxia-inducible factor-1α (HIF-1α) inhibited by small interfering RNAs (siRNAs). inhibition effect on RA-FLS migration further investigated. protein level HIF-1α, RhoA, focal adhesion kinase (FAK), myosin light...
Ischemic heart disease (IHD) may share biological mechanisms with cancer, including ovarian through pathways such as chronic inflammation and oxidative stress. However, the relationship between IHD cancer subtypes remains unclear. This study used Mendelian randomization (MR) to explore potential causal associations. A two-sample MR analysis was conducted using genetic instruments for from large-scale genome-wide association studies (GWAS). The inverse-variance weighted (IVW) method primary...
Context: Osteoporosis is one of the most common bone diseases, and radix Pueraria lobata (Willd.) Ohwi possesses an obvious therapeutical effect on postmenopausal osteoporosis.Objective: This study investigates anti-osteoporotic activity puerarin 6″-O-xyloside (PXY) ovariectomized mice its related mechanism.Materials methods: Osteoporotic model was established by ovariectomy (OVX). A total 50 were divided into five groups (n = 10): sham, OVX group, PXY treatment (20, 40, 60 mg/kg/d, i.p.)....
The stability and targeting ability of nanocarrier gene delivery systems are necessary conditions to ensure the good therapeutic effect low nonspecific toxicity cancer treatment. Poly(ethylene glycol) (PEG) has been widely applied for improving as a spacer linking ligands nanocarriers improve targetability. However, cellular uptake endosomal escape capacity seriously harmed due introduction PEG. In present study, we synthesized new vector by coupling divalent folate-PEG (PEG3.4k-FA2) onto...
Cationic polymers have been regarded as promising non-viral gene carriers because of their advantages over viral vectors, such low cost, a high level safety and easy manipulation. However, poor transfection efficiency in the presence serum toxicity are still limiting issues for clinical applications. In addition, lack adequate understanding delivery mechanism hinders development to some extent. this study, new polycations (PAPEs) consisting generation polyamidoamine (PAMAM) core branched...
The rapid progress of sequencing technology has greatly facilitated the de novo genome assembly pig breeds. However, wild boar is still lacking, hampering our understanding chromosomal and genomic evolution during domestication from boars into domestic pigs. Here, we sequenced assembled a European (ASM2165605v1) using long-range information provided by 10× Linked-Reads sequencing. We achieved high-quality with contig N50 26.09 Mb. Additionally, 1.64% contigs (222) lengths 107.65 kb to 75.36...
Pirfenidone (PFD), a synthetic arsenic compound, has been found to inhibit angiogenesis at high concentrations. However, the biphasic effects of different PFD concentrations on have not yet elucidated, and present study used an in vitro model explore mechanisms underlying this response. The effect initial vascular endothelial cells was investigated through Matrigel tube formation assay, impact cell migration evaluated scratch transwell experiments. Moreover, expression key cytokines, matrix...
Human spermatozoa proteomics exposed to some physical, biological or chemical stressors is being explored. However, there a lack of optimized sample preparation methods achieve in-depth protein coverage for sperm cells. Meanwhile, it not clear whether antibiotics can regulate proteins affect quality. Here, we systematically compared total six different extraction based the combination three commonly used lysis buffers and physical strategies. The urea buffer combined with ultrasonication...
We developed a facile one-step method to produce ready-to-use quantum dots based on peptide sequence containing hexahistidine(his6-tag), poly(ethylene glycol) (PEG), and functional group, which lead stable customized peptide–QDs conjugates that could serve as fluorescent nanoprobes for biological imaging detection.
Polyamidoamine (PAMAM) dendrimers are a class of unique nanomaterials which attracted attention because their extraordinary properties, such as highly branched structure and types terminal primary groups. In addition, development in PAMAM chemical modification has broadened its biological application especially for drug gene delivery. this study, PAMAMs covalently conjugated onto α-Cyclodextrin (α-CD) via amide bonds obtaining the starburst cationic polymers (CD-PG2). The composition CD-PG2...
Genes that originate during evolution are an important source of novel biological functions. Retrogenes functional copies genes produced by retroduplication and as such located in different genomic positions. To investigate retroposition patterns retrogene expression, we computationally identified interchromosomal events nine portions the phylogenetic history malaria mosquitoes, making use species do or not have classical sex chromosomes to test roles sex-linkage. We found 40 a significant...
Metastasis and resistance are main causes to affect the outcome of current anticancer therapies. Heat shock protein 90 (Hsp90) as an ATP-dependent molecular chaperone takes important role in tumor metastasis resistance. Targeting Hsp90 downregulating its expression show promising inhibiting In this study, a redox-responsive dual-drug nanocarrier was constructed for effective delivery commonly used chemotherapeutic drug PTX, COA-modified 4-arm PEG polymer (4PSC) synthesized. COA, active...
Hypoplastic left heart syndrome (HLHS) is a rare but fatal birth defect in which the side of underdeveloped. HLHS accounts for 2% to 4% congenital anomalies. Whole genome sequencing (WGS) was conducted family trio consisting proband and his parents. A homozygous variant detected PTPRB (Protein Tyrosine Phosphatase Receptor Type B) gene by functional annotation co-segregation analysis. Sanger used confirm genotypes variant. The silico prediction tools, including Mutation Taster, SpliceAI,...
Aim: To validate the efficacy of nanocomplexes from RGD-modified polyamidoamine (PAMAM G1) copolymer for prevention restenosis. Materials & methods: Generation 1.0 G1)-based copolymers (PGP) and RGD modified PGP (PGP-RGD) were synthesized its properties evaluated. Intravascular VEGF165 release tests performed. Results: The PGP-RGD1 (2.6% grafting rate) exhibited lower cytotoxicity larger combining ability with pDNA. complexes had sizes 80–160 nm zeta potentials 3–20 mV. Transfection...
Objective: To investigate the effect of Sandwich Learning (SL) in theory teaching Histology and Embryology. Methods: 110 freshmen majoring clinical medicine were randomly chosen as experimental group Learning, while 111 students at same grade control for traditional lecture-style teaching. After different teaching, from both groups surveyed by questionnaires. And they had to take examinations about theoretical knowledge specimen Then teachers marked all exam papers according scoring...