A5080297327- Amyotrophic Lateral Sclerosis Research
- Parkinson's Disease Mechanisms and Treatments
- Neurogenetic and Muscular Disorders Research
- Epigenetics and DNA Methylation
- Neurofibromatosis and Schwannoma Cases
- Restless Legs Syndrome Research
- RNA regulation and disease
- Meningioma and schwannoma management
- Sleep and Wakefulness Research
- Alzheimer's disease research and treatments
- Neurological disorders and treatments
- Neurological diseases and metabolism
- biodegradable polymer synthesis and properties
- Sleep and related disorders
- Cancer-related molecular mechanisms research
- Lysosomal Storage Disorders Research
- Prion Diseases and Protein Misfolding
- Nuclear Receptors and Signaling
- Autophagy in Disease and Therapy
- Circadian rhythm and melatonin
- RNA Research and Splicing
- Oral microbiology and periodontitis research
- Circular RNAs in diseases
- Plant and Fungal Interactions Research
- Protein Tyrosine Phosphatases
Shanghai Ninth People's Hospital
2024-2025
Shanghai Jiao Tong University
2024-2025
Sichuan University
2022-2025
West China Hospital of Sichuan University
2022-2025
Sun Yat-sen Memorial Hospital
2024
Jilin Agricultural University
2024
Civil Aviation University of China
2024
Kunming University of Science and Technology
2024
Sun Yat-sen University
2024
Institute for Neurodegenerative Disorders
2022-2023
Melatonin is an indole neuroendocrine hormone that mainly secreted by the pineal gland to regulate circadian rhythm, antioxidation, and immune regulation. plays important role in T cell-mediated responses against cancer, infections, development of many autoimmune diseases. The aim this study was investigate immunomodulatory effects melatonin on T/B cell activation pinealectomy mice. improved procedure for mice presented a good animal model be used follow-up studies melatonin. After...
Motor neuron degeneration in amyotrophic lateral sclerosis (ALS) is a form of apoptosis, but the mechanisms underlying this neuronal cell death remain unclear. Numerous studies demonstrate abnormally elevated and active p53 central nervous system ALS patients. Activation p53-regulated pro-apoptotic signaling pathways may trigger motor death. We previously reported decreased expression long non-coding RNA NR3C2-8:1 (Lnc-NR3C) leukocytes Here, we show lnc-NR3C promotes p53-mediated by...
Background: Fatigue is a prevalent non-motor symptom that often appears in the early stages of Parkinson’s disease (PD). Plasma neurofilament light chain (NfL) was elevated PD patients and may be considered potential biomarker for both motor cognitive progression. Objectives: In this study, we explored association between plasma NfL levels various fatigue subtypes prediction baseline subtype conversion. Methods: Patients with were classified into four categories: persistent fatigue, never...
Amyotrophic lateral sclerosis-frontotemporal spectrum disorder (ALS-FTSD) is a fatal neurodegenerative condition, and identifying its modifiable risk factors critical public health issue. This large-scale prospective cohort study investigated the role of sleep-related in ALS-FTSD using data from 396,918 UK Biobank participants. Eight exposures were assessed, Cox proportional hazards regression was employed to evaluate their associations with incidence. Subgroup sensitivity analyses conducted...
Abstract Lateralization in mating behavior is increasingly recognized as a significant trait insect species, yet its influence associated with gender, and sexual experience Ostrinia furnacalis (Guenée) remains poorly understood. This study examines how lateralized behaviors, interact to success efficiency O. furnacalis. We conducted controlled trials assess gender shape directional approaches (eg right- or left-biased) turnings 180° across the pre-copulatory, copulatory, post-copulatory...
Abstract Background: Circular RNAs (circRNAs) regulate tumor development by interacting with microRNAs. However, limited research has been conducted on the roles of circRNAs in gliomas. Therefore, we sought to demonstrate function and molecular mechanism circHAS2 Methods: CircHAS2, hsa-miR-508-3p, RPL23, MMP9 mRNA levels were assessed qRT-PCR. RPL23 protein determined western blotting immunohistochemical staining. Glioma cell migration invasion Transwell assays. The interaction between...
Background and Objective: Primary lung cancer is a lethal rapidly-developing type one of the most leading causes deaths. Materials Methods: Statistical methods such as Cox regression are usually used to detect prognosis factors disease. This study investigated survival prediction using machine learning algorithms. The clinical data 28,458 patients with primary cancers were collected from Surveillance, Epidemiology, End Results (SEER) database. Results: indicated that rate women was often...
Plexiform neurofibromas (PNFs) are a prevalent and severe phenotype associated with NF1, characterized by high teratogenic rate potential for malignant transformation. The growth recurrence of PNFs attributed to aberrant proliferation migration Nf1-deficient Schwann cells. Protein tyrosine phosphatase receptor S (PTPRS) is believed modulate cell invasion inhibiting the EMT process in NF1-derived peripheral nerve sheath tumors. Nevertheless, specific role PTPRS remains be elucidated. study...
A variant of the phospholipase A2 group VI gene (PLA2G6, PARK14) has been found to cause early-onset Parkinson's disease (EOPD). In this study, we reprogrammed peripheral blood mononuclear cells from a 39-year-old patient with EOPD carrying homozygous PLA2G6 mutation c.1898C > T (p. A633V) generate human induced pluripotent stem cell line LNDWCHi001-A. This was identified based on markers and displayed differentiation capacity, providing an essential model for studying pathogenesis drug screening.
Huntington’s disease (HD) is an autosomal dominant inherited neurodegenerative disorder caused by CAG repeats expansion. There a paucity of comprehensive clinical analysis in Chinese HD patients due to the low prevalence Asia. We aimed comprehensively describe motor, neuropsychiatric symptoms, and functional assessment with from China. A total 205 were assessed Unified Disease Rating Scale (UHDRS), short version Problem-Behavior Assessment (PBA-s), Hamilton Depression (HAMD) Beck Inventory...
Background Melatonin has been shown to play a protective role in the development and progression of cancer. However, relationship between alterations melatonergic microenvironment cancer remained unclear. Methods We performed comprehensive investigation on 12 genes their relevance occurrence, survival by integrating multi-omics data from microarray analysis RNA sequencing across 11 types. Specifically, that we investigated, which reflect microenvironment, included three membrane receptor...