A5064615194- Amyotrophic Lateral Sclerosis Research
- RNA Research and Splicing
- Neurogenetic and Muscular Disorders Research
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Parkinson's Disease Mechanisms and Treatments
- Mitochondrial Function and Pathology
- Alzheimer's disease research and treatments
- Polysaccharides and Plant Cell Walls
- Neurological disorders and treatments
- Autophagy in Disease and Therapy
- Diet, Metabolism, and Disease
- Nuclear Receptors and Signaling
- Metabolism, Diabetes, and Cancer
- Reproductive Biology and Fertility
- Neuroscience and Neuropharmacology Research
- Sperm and Testicular Function
- RNA modifications and cancer
- Pancreatic function and diabetes
- Medicinal Plant Pharmacodynamics Research
- Seaweed-derived Bioactive Compounds
- Regulation of Appetite and Obesity
- Microbial Inactivation Methods
- Cerebrovascular and genetic disorders
- Chromatography in Natural Products
Sichuan University
2016-2025
West China Hospital of Sichuan University
2021-2024
State Key Laboratory of Biotherapy
2014-2022
Sichuan Agricultural University
2019-2020
Reactive astrogliosis has been demonstrated to have a role in Parkinson's disease (PD); however, astrocyte-specific plasma glial fibrillary acidic protein (GFAP)'s correlation with PD progression remains unknown. We aimed determine whether GFAP can monitor and predict progression.A total of 184 patients 95 healthy controls (HCs) were included this prospective cohort study followed-up for 5 years. Plasma GFAP, amyloid-beta (Aβ), p-tau181, neurofilament light chain (NfL) measured at baseline...
We conducted a systematic review and meta-analysis of observational case-control studies to evaluate markers oxidative stress in seminal plasma patients with male infertility.Current evidence links infertility, which multiple have been widely detected, publishing inconsistent results regard the role evaluation infertility. Therefore, on this issue is necessary.From 1024 articles initially retrieved, 65 were included our 11 markers, containing 3819 infertility 2012 controls. The...
The high recurrence frequency of gliomas but deficiency effective treatment and prevalent chemoresistance have elicited interests in exploring developing new agents. Paris polyphyllins are monomers extracted from rhizome polyphylla var. yunnanensis. Here, we first reported that polyphyllin VII (PP7) exhibited cytotoxic effect on glioma cells. PP7 significantly suppressed the viability induced cell death U87-MG U251 cells after 24 h, with IC50 values <mml:math...
Abstract With the increase of aging population and prevalence obesity, incidence cardiovascular disease (CVD) cancer has also presented an increasing tendency. These two different diseases, which share some common risk factors. Relevant studies in field reversing Cardio-Oncology have shown that phenotype CVD a significant adverse effect on tumor prognosis, is mainly manifested by positive correlation between malignant progression concomitant tumors. This distal crosstalk link diseases makes...
Motor neuron degeneration in amyotrophic lateral sclerosis (ALS) is a form of apoptosis, but the mechanisms underlying this neuronal cell death remain unclear. Numerous studies demonstrate abnormally elevated and active p53 central nervous system ALS patients. Activation p53-regulated pro-apoptotic signaling pathways may trigger motor death. We previously reported decreased expression long non-coding RNA NR3C2-8:1 (Lnc-NR3C) leukocytes Here, we show lnc-NR3C promotes p53-mediated by...
Abnormalities in glycolytic pathways are prominent factors the pathogenesis of osteoarthritis (OA). The key enzyme Hexokinase 2 (HK2) is highly expressed chondrocytes OA; however, its role remains unclear. Pulsed electromagnetic field (PEMF) commonly used for treatment OA. However, PEMF cartilage damage and underlying mechanisms not well understood. Herein, we found that HK2 suppression down-regulated catabolic alleviated inflammatory responses OA chondrocytes, whereas overexpression...
Amyotrophic lateral sclerosis-frontotemporal spectrum disorder (ALS-FTSD) is a fatal neurodegenerative condition, and identifying its modifiable risk factors critical public health issue. This large-scale prospective cohort study investigated the role of sleep-related in ALS-FTSD using data from 396,918 UK Biobank participants. Eight exposures were assessed, Cox proportional hazards regression was employed to evaluate their associations with incidence. Subgroup sensitivity analyses conducted...
The pandemic tendency of obesity and its strong association with serious co-morbidities have elicited interest in the underlying mechanisms these pathologies. Lipid homeostasis, closely involved obesity, has been reported to be regulated by multiple pathways. mTORC1 is emerging as a critical regulator lipid metabolism. Here, we describe that consumption soy isoflavones, structural similarity estradiol, could mitigate through an AKT/mTORC1 pathway. Fed diet-induced (DIO) male rats exhibited...
Abstract Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive loss of motor neurons. Improving neuronal survival in ALS remains significant challenge. Previously, we identified Lanthionine synthetase C-like protein 1 (LanCL1) as antioxidant defense gene, the genetic deletion which causes apoptotic neurodegeneration brain. Here, report vivo data using transgenic SOD1 G93A mouse model indicating that CNS-specific expression LanCL1 transgene...
The morbidity and mortality of primary liver cancer is one the highest amongst all cancers. Deficiency effective treatment characteristics metastasis are believed to be responsible for this situation, thus a great demand required new agent development. Polyphyllin II (PP2), an important steroidal saponin extracted from Rhizoma Paris, has emerged as potential anti-cancer agent, but effects PP2 in cancers its underlying mechanisms remain unexplored. In our study, we found that could remarkably...
In this study, the Nelumbo nucifera leaf polysaccharide (NNLP) was isolated by hot water extraction and ethanol precipitation. DEAE anion exchange chromatography gel filtration were further performed to obtained purified fraction NNLP-I-I, molecular weight of which 16.4 kDa. The monosaccharide composition analysis linkage units determination showed that NNLP-I-I a pectic polysaccharide. addition, NMR spectra revealed mainly consisted homogalacturonan backbone rhamnogalacturonan I, containing...
Platycodon grandiflorus is a plant widely used in traditional Chinese medicine, of which polysaccharides are reported to be the main components responsible for its bio-functions. In this work, inulin-type fructan (PGF) was obtained by DEAE anion exchange chromatography from water extracted P. grandifloras. Characterization performed with methanolysis, methylation, and NMR results showed that PGF β-(2-1) linked fructan, terminal glucose degree polymerization 2⁻10. order study biofunctions,...
Obesity is a common metabolic disorder that increases the risk of many diseases, such as type II diabetes, hypertension, cardiovascular disease.Hypothalamus plays very important role in progression obesity, and studies reveal hypothalamic injures are implicated obesity processes.Here, we describe consumption soy isoflavones, with structural similarity to estradiol, could mitigate through improving inflammation apoptosis, which induced by oxidative stress.Also, our vitro demonstrate daidzein...
Abstract Background Epidemiological and clinical studies have suggested comorbidity between frontotemporal dementia (FTD) psychiatric disorders. FTD patients carrying specific mutations were at higher risk for some disorders, vice versa, implying potential shared genetic etiology, which is still less explored. Methods We examined the correlation using summary statistics from genome-wide association analyzed their enrichment leveraging conditional false discovery rate method. Furthermore, we...
Oligodendrocytes ensheath axons to form compact insulating multilamellar structures known as myelin.Tmem10 is a novel type I transmembrane glycoprotein that highly expressed in oligodendrocytes and whose biological function remains largely unknown.Furthermore, the expression pattern of Tmem10 matter some controversy.Given inconsistency its lack validated specific antibodies, not widely accepted marker for mature oligodendrocytes.As means solve these problems aid future studies...
Abstract Plasma Alzheimer’s disease-related pathological biomarkers’ role in Parkinson’s disease (PD) remains unknown. We aimed to determine whether plasma biomarkers can predict PD progression. A total of 184 patients and 86 healthy controls were included followed up for 5 years. phosphorylated tau181 (p-tau181), Aβ40, Aβ42 measured at baseline the 1- 2-year follow-ups using Quanterix-single-molecule array. Global cognitive function motor symptoms assessed Montreal Cognitive Assessment...
Neuroglobin (NGB), distributed mainly in central and peripheral nervous systems, is a nerve globin with neuroprotective effects against oxidative stress resulting from hypoxia ischemia. Recent studies have indicated that the expression of NGB related to neurodegenerative disorders cancers, but molecular mechanisms for its transcriptional regulation protection are not well defined. Here, we report glioma grade negatively regulated by PPARγ. Specific PPARγ agonist reduces NGB, while inhibitor...
A variant of the phospholipase A2 group VI gene (PLA2G6, PARK14) has been found to cause early-onset Parkinson's disease (EOPD). In this study, we reprogrammed peripheral blood mononuclear cells from a 39-year-old patient with EOPD carrying homozygous PLA2G6 mutation c.1898C > T (p. A633V) generate human induced pluripotent stem cell line LNDWCHi001-A. This was identified based on markers and displayed differentiation capacity, providing an essential model for studying pathogenesis drug screening.
Excessive food/energy intake is linked to obesity and metabolic disorders, such as diabetes. The hypothalamus in the brain plays a critical role control of food peripheral metabolism. signaling pathways hypothalamic neurons that regulate metabolism need be better understood for developing pharmacological interventions manage eating behavior obesity. Mammalian target rapamycin (mTOR), serine/threonine kinase, master regulator cellular different cell types. Pharmacological manipulations mTOR...