A5054840622- Cancer, Hypoxia, and Metabolism
- Autophagy in Disease and Therapy
- Mitochondrial Function and Pathology
- Ubiquitin and proteasome pathways
- Adipose Tissue and Metabolism
- Epigenetics and DNA Methylation
- Remote Sensing in Agriculture
- Land Use and Ecosystem Services
- High Altitude and Hypoxia
- Metabolomics and Mass Spectrometry Studies
- Urban Heat Island Mitigation
- Remote Sensing and Land Use
- Eicosanoids and Hypertension Pharmacology
- Spaceflight effects on biology
- Ion channel regulation and function
- Water Resources and Management
- Gut microbiota and health
- Microbial Inactivation Methods
- Neuroinflammation and Neurodegeneration Mechanisms
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurological Disease Mechanisms and Treatments
- Respiratory Support and Mechanisms
- Atmospheric and Environmental Gas Dynamics
- Cancer-related molecular mechanisms research
- Tryptophan and brain disorders
Yunnan University
2022-2025
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
2013-2023
Beijing Institute of Education
2013-2023
Beijing Proteome Research Center
2022
Southern University of Science and Technology
2021
Chinese Institute for Brain Research
2018
Xinxiang Central Hospital
2015
Academy of Military Medical Sciences
2013
The urban heat island effect (UHI) has become a major challenge for sustainable development. In recent decades, the significant development of agglomerations intensified complex interaction and comprehensive impact UHI effect, but spatiotemporal pattern regional islands been poorly understood. Based on land surface temperature (LST) from 2001 to 2020, this study uses relative (RLST) method quantify (RHI) Central Yunnan Urban Agglomeration (CYUA) beyond single city, combines variety spatial...
Abstract Mitophagy is an important metabolic mechanism that modulates mitochondrial quality and quantity by selectively removing damaged or unwanted mitochondria. BNIP3 (BCL2/adenovirus e1B 19 kDa protein interacting 3), a outer membrane protein, mitophagy receptor mediates under various stresses, particularly hypoxia, since hypoxia-responsive protein. However, the underlying mechanisms regulate thus mediate hypoxic conditions remain elusive. Here, we demonstrate in hypoxia JNK1/2 (c-Jun...
The treatment of stroke is limited by a short therapeutic window and lack effective clinical drugs. Methylene blue (MB) has been used in laboratories clinics since the 1890s. Few studies have reported neuroprotective role MB cerebral ischemia-reperfusion injury. However, whether how protects against acute ischemia (ACI) injury was unclear. In this study, we investigated effect on revealed that protected ACI augmenting mitophagy. Using rat middle artery occlusion (MCAO) model, demonstrated...
In recent years, global climate changes and human activities have significantly reshaped ecosystems, posing a challenging aspect for research—accurately understanding how affect vegetation. This study employs the Carnegie–Ames–Stanford Approach (CASA) model to analyze spatiotemporal distribution of Net Primary Productivity (NPP) in Central Yunnan Urban Agglomeration (CYUA) from 1982 2019. It measures activity intensity using Comprehensive Human Activity Intensity Index (CHAII), which is...
The kidney is vulnerable to hypoxia-induced injury. One of the mechanisms underlying this phenomenon cell apoptosis triggered by hypoxia-inducible factor-1-alpha (HIF-1α) activation. MicroRNA-210 (miR-210) known be induced HIF-1α and can regulate various pathological processes, but its role in hypoxic injury remains unclear. Here, both kinds rat systemic hypoxia local models, we found miR-210 levels were upregulated significantly injured kidney, especially renal tubular cells. A similar...
This study aimed to determine the effects of Bifidobacterium bifidum TMC3115, Lactobacillus plantarum 45 (LP45) and their combined use on cognitive performance gut microbiota in APP/PS1 mice. The mice were randomly divided into four groups: Alzheimer's disease (AD) model group, TMC3115 group [1 × 109 colony forming unit (CFU)], LP45 (1 CFU) a mixture (5 108 CFU). wild-type littermates chosen as normal control. sacrificed at end 22 weeks after behavioral evaluation. Collected cecum content...
Hypoxia is the most critical factor for maintaining stemness. During embryonic development, neural stem cells (NSCs) reside in hypoxic niches, and different oxygen pressures time of hypoxia-exposure play important roles development NSCs. Such niches exist adult brain tissue, where precursors originate. Hypoxia-inducible factors (HIFs) are key transcription heterodimers consisting regulatory α-subunits (HIF-1α, HIF-2α, HIF-3α) a constitutive β-subunit (HIF-β). Regulation on downstream targets...
Hypoxia is an important factor in regulation of cell behavior both under physiological and pathological conditions. The mechanisms hypoxia-induced death have not been completely elucidated yet. It well known that Ca2+ critically related to survival. Hypoxia-inducible factor-1α (HIF-1α) a core regulatory during hypoxia, L-type voltage-dependent channels (L-VDCCs) reported play critical role This study was conducted explore the relationship between L-VDCC expression HIF-1α PC12 cells hypoxia....
Abstract Hypoxia as a microenvironment or niche stimulates proliferation of neural stem cells (NSCs). However, the underlying mechanisms remain elusive. Autophagy is protective mechanism by which recycled cellular components and energy are rapidly supplied to cell under stress. Whether autophagy mediates NSCs hypoxia how induces unclear. Here, we report that facilitates embryonic NSC through HIF-1/mTORC1 signaling pathway-mediated autophagy. Initially, found greatly induced in NSCs, while...
Extreme drought has negative impacts on the health of vegetation and stability ecosystems. In this study, CASA model was employed to estimate net primary productivity over Yunnan Plateau. The time-lag effects were observed within a 0–6 month period extreme droughts using Pearson correlation coefficient. resistance during quantified, recovery capability following these events analyzed ARIMA model. Moreover, study investigated response across diverse altitudinal gradients. results showed that:...
We first reported the role of 5-hydroxymethyl-2-furfural (5-HMF) against hypoxia. Here, we studied mechanism by using oxygen-dependent degradation domain (ODD)-Luc mice, which are a useful model to probe stabilization hypoxia-inducible factor 1α (HIF-1α). Compared with three other compounds that have been in stabilizing HIF-1α, 5-HMF caused stronger bioluminescence, is indicative HIF-1α stability brain and kidney ODD-Luc mice. further demonstrated protein accumulated response brains kidneys...
The treatment of obese patients is a topic investigated by an increasing number researchers.This study aimed to elucidate the possible inhibitory effect tangeritin on development and function fat cells.3T3-L1 cells were grown confluence subjected different concentrations tangeritin.The most effective inhibition concentration was determined MTT assay.The treated real-time reverse transcriptase PCR western blot analysis, detect changes in CCAAT/enhancer binding protein (C/EBP)α, C/EBPβ,...
For hematopoietic stem and progenitor cells (HSPCs), hypoxia is a specific microenvironment known as the hypoxic niche. How regulates erythroid differentiation of HSPCs remains unclear. In this study, we show that evidently accelerates differentiation, autophagy plays pivotal role in process. We further determine mTORC1 signaling suppressed by to relieve its inhibition autophagy, with process activity gradually decreases increases accordingly. Moreover, provide evidence HIF-1 target gene...
Water use efficiency (WUE) is an effective index to study the coupling of land carbon and water cycle. The Qinghai-Tibet Plateau most important ecological security barrier in China. Understanding characteristics mechanism WUE for cycle resources rational utilization plateau. Based on MODIS data gross primary productivity (GPP) evapotranspiration (ET), we analyzed spatial-temporal variations over effects climate factors. results showed that had upward trend under combined action GPP ET during...
Abstract Mitophagy is an important metabolic mechanism that modulates mitochondrial quality and quantity by selectively removing damaged or unwanted mitochondria. BNIP3, a outer membrane protein, mitophagy receptor mediates under various stresses, particularly hypoxia, since BNIP3 hypoxia-responsive protein. However, the underlying mechanisms regulate thus mediate hypoxic conditions remain elusive. Here, we demonstrate in hypoxia JNK1/2 phosphorylates at Ser 60/Thr 66, which hampers...
To further study the regulation of hypoxia on Alzheimer's disease (AD) pathogenesis, we investigate effect cell survival and expression related proteins in HEK293 cells stably expressing APP695 Swedish mutantK595N/M596L (HEK293-APP695 cells).HEK293-APP695 were cultured at condition (0.3% O2). The rate HEK293-APP695 was measured by CCK-8 assay. protein levels APP, APP-CTFs BACE1 detected Western blot.The obviously decreased after exposed to hypoxia. APP reduced, increased under hypoxia.Our...