A5084142619- Nanoplatforms for cancer theranostics
- Electrospun Nanofibers in Biomedical Applications
- Periodontal Regeneration and Treatments
- Nanoparticle-Based Drug Delivery
- Tissue Engineering and Regenerative Medicine
- Dendrimers and Hyperbranched Polymers
- Ferroptosis and cancer prognosis
- Peptidase Inhibition and Analysis
- Cancer Immunotherapy and Biomarkers
- Bone Tissue Engineering Materials
- RNA Interference and Gene Delivery
- ATP Synthase and ATPases Research
- Graphene and Nanomaterials Applications
- Enzyme function and inhibition
- Innovative Microfluidic and Catalytic Techniques Innovation
- Circular RNAs in diseases
- Crystallization and Solubility Studies
- Drug Solubulity and Delivery Systems
- Biochemical effects in animals
- Photoacoustic and Ultrasonic Imaging
- Advanced Drug Delivery Systems
- Lung Cancer Research Studies
- Heat shock proteins research
- Advanced biosensing and bioanalysis techniques
- 3D Printing in Biomedical Research
Guangzhou Medical University
2020-2025
State Key Laboratory of Respiratory Disease
2020-2025
Third Affiliated Hospital of Guangzhou Medical University
2021
Sun Yat-sen University
2017-2019
Periodontitis is a widespread dental disease affecting 10 to 15% of worldwide adult population, yet the current treatments are far from satisfactory. The human periodontal ligament stem cell promising potential seed population type in cell-based therapy and tissue regeneration, which require appropriate scaffold provide mimic extracellular matrix. Zein, native protein derived corn, has an excellent biodegradability, therefore becomes hotspot on research application field biomaterials....
In bone tissue engineering, it is important for biomaterials to promote the osteogenic differentiation of stem cells achieve regeneration.
Cell viability, adhesion, proliferation, and differentiation of neural stem cells (NSCs) on zein nanofibrous membranes could be improved by poly(<sc>l</sc>-lysine) modification.
Abstract Colorectal cancer cells are capable of reprogramming normal fibroblasts into tumor‐supportive cancer‐associated (CAFs), whose immunosuppressive crosstalk profoundly hinders antitumor immune responses. In this work, a significant association between CAF activation and disease‐free survival outcomes is established in colorectal patients. Complementary biological investigations confirm the interactive dynamics that drive activation. Based on these, fibroblast‐activation protein...
Delivering traditional DNA-damaging anticancer drugs into mitochondria to damage is a promising chemotherapy strategy. The impermeability of this mitochondrial inner membrane, however, impedes the delivery drug molecules that could impact other important biological roles mitochondria. Herein, prodrug camptothecin (CPT)-triphenylphosphine (TPP) modified with hyaluronic acid (HA) via electrostatic adsorption (HA/CPT-TPP, HCT) was used mediate accumulation CPT. These nanoparticles (NPs) showed...
Simultaneous inhibitions of primary tumor growth and distant metastasis are very critical for cancer patients to improve their survival cure rates. Although photodynamic therapy (PDT) shows great potential treatment, it often exacerbates hypoxia with a reduced therapeutic efficacy subsequently contributes carcinoma progression metastatic dissemination. To solve these issues, self-delivery nanoinhibitors (PNI) developed targeted inhibition. PNI composed carbonic anhydrase inhibitor (CAi),...
Metastasis and resistance are main causes to affect the outcome of current anticancer therapies. Heat shock protein 90 (Hsp90) as an ATP-dependent molecular chaperone takes important role in tumor metastasis resistance. Targeting Hsp90 downregulating its expression show promising inhibiting In this study, a redox-responsive dual-drug nanocarrier was constructed for effective delivery commonly used chemotherapeutic drug PTX, COA-modified 4-arm PEG polymer (4PSC) synthesized. COA, active...
Lung cancer remains one of the leading causes death in humans. Gefitinib is an inhibitor epidermal growth factor receptor tyrosine kinase (EGFR-TKI) commonly used to suppress tumour growth. However, constantly use gefitinib results drug-resistance, reduced efficacy and undesired side effects. To circumvent these drawbacks, targeted photothermal therapies have emerged as effective strategies. Herein, we are first adopt a black phosphorus (BP) nanoparticle-based novel delivering strategy by...
Abstract Nanotechnology has been widely used in drug design recent years, showing great potential and advantages tumor therapy. However, the application of most traditional nanomedicines is still limited by low loading rate, poor targeting ability, systemic toxicity. Based on characteristics microenvironments, numerous studies indicate that construction stimuli‐responsive nanocarriers can effectively solve above problems improving delivery efficiency, reducing side effects, enhancing...
Critical-sized bone defects raise great challenges. Zein is of interest for regeneration, but it has limited ability to stimulate cell proliferation. In this regard, a poly (aspartic acid) (PAsp)-zein hybrid promising, as PAsp can promote rat marrow stromal (rBMSCs) proliferation and osteogenic differentiation. This research aimed develop electrospun PAsp-modified zein nanofibers realize critical-sized repair.Three groups were prepared, they grafting percentages 0% (zein), 5.32% (ZPAA-1),...
Indocyanine green (ICG), a near-infrared (NIR) fluorescent dye approved by the Food and Drug Administration (FDA), has been extensively used as photoacoustic (PA) probe for PA imaging. However, its practical application is limited poor photostability in water, rapid body clearance, non-specificity. Herein, we fabricated novel biomimetic nanoprobe coating ICG-loaded mesoporous silica nanoparticles with cancer cell membrane (namely, CMI) This exhibited good dispersion, large loading...
Tumor therapy should not only pursue the efficient killing of tumor tissues, but also consider restriction on metastasis residual cells after local destruction, because would bring more unpredictable consequences. In view this, a combinational drug nanosystem was constructed to enhance activity as well inhibit through rational synergy antitumor and anti-inflammatory functions small molecule drugs, photosensitizer Ce6 sulfasalazine (SAS). Internalized nanoparticles can activate programmed...