A5100450547- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
- Ion channel regulation and function
- Neurological disorders and treatments
- Cardiac Ischemia and Reperfusion
- Syphilis Diagnosis and Treatment
- Cardiomyopathy and Myosin Studies
- Fuel Cells and Related Materials
- Heart Failure Treatment and Management
- Endodontics and Root Canal Treatments
- Liver Disease Diagnosis and Treatment
- Statistical Methods in Clinical Trials
- Vascular anomalies and interventions
- Recycled Aggregate Concrete Performance
- Diabetes Treatment and Management
- Cardiac Imaging and Diagnostics
- Innovative concrete reinforcement materials
- Cardiovascular Function and Risk Factors
- Electric Motor Design and Analysis
- Cardiovascular Effects of Exercise
- Dental Radiography and Imaging
- Structural Behavior of Reinforced Concrete
- Dental Anxiety and Anesthesia Techniques
Shandong University
2024-2025
WinnMed
2007-2025
Luohe Medical College
2024-2025
Mayo Clinic Health System
2022-2024
Mayo Clinic
2004-2024
Mayo Clinic in Florida
2023-2024
ATP Clinical Research (United States)
2024
Sichuan University
2020-2024
Wuhan Institute of Bioengineering
2023
Station Biologique de Roscoff
2023
Atrial fibrillation is a rhythm disorder characterized by chaotic electrical activity of cardiac atria. Predisposing to stroke and heart failure, this common condition increasingly recognized as heritable disorder. To identify genetic defects conferring disease susceptibility, patients with idiopathic atrial fibrillation, lacking traditional risk factors, were evaluated. Genomic DNA scanning revealed nonsense mutation in KCNA5 that encodes Kv1.5, voltage-gated potassium channel expressed...
Abstract Stripe (yellow) rust, caused by Puccinia striiformis f. sp. tritici ( Pst ), can significantly affect wheat production. Cloning resistance genes is critical for efficient and effective breeding of stripe rust resistant cultivars. One gene Yr10 CG ) underlying the locus has been cloned. However, following haplotype linkage analyses indicate presence additional gene(s) underlying/near locus. Here, we report cloning YrNAM in this region using method sequencing trait-associated...
Since May 2022, mutant strains of mpox (formerly monkeypox) virus (MPXV) have been rapidly spreading among individuals who not traveled to endemic areas in multiple locations, including Europe and the United States. Both intracellular extracellular forms outer membrane proteins that can stimulate immune response. Here, we investigated immunogenicity MPXV structural such as A29L, M1R, A35R, B6R a combination vaccine, protective effect against 2022 strain was also evaluated BALB/c mice. After...
Microplastic (MP) pollution, an emerging global change factor, disturbs the ecosystem functioning. Inland wetlands, providing important services, might be sink for MPs. Understanding distribution, source, and fate of MPs in inland wetland ecosystems is a prerequisite developing effective management strategy. Here, different types including river wetland, constructed lake were selected to explore pollution patterns therein. Results showed that abundance soil ranges from 532 4309 items/kg....
BackgroundThe outcomes of left bundle branch pacing (LBBP) and ventricular septal (LVSP) in patients with heart failure remain to be learned.ObjectiveThe objective this study was assess the echocardiographic clinical LBBP, LVSP, deep (DSP).MethodsThis retrospective included who met criteria for cardiac resynchronization therapy (CRT) underwent attempted LBBP 5 Mayo centers. Clinical, electrocardiographic, data were collected at baseline follow-up.ResultsA total 91 consecutive study. 52 had...
Some antipsychotic drugs have been found to prolong the QT interval on electrocardiographic (ECG) recordings, a phenomenon which, when severe, may facilitate occurrence of complex ventricular arrhythmias such as torsade de pointes.However, effects these cardiac repolarization process not evaluated extensively. This study was designed examine potency five in lengthening perfused feline heart: haloperidol, risperidone, sertindole, clozapine, and olanzapine. The hearts were infused with...
Ventricular load can precipitate development of the heart failure syndrome, yet molecular components that control cardiac adaptive response to imposed demand remain partly understood. Compromised ATP‐sensitive K + (K ATP ) channel function renders vulnerable stress, implicating this metabolic sensor in homeostatic would normally prevent progression disease. Here, pressure overload was on left ventricle by transverse aortic constriction wild‐type and mice lacking sarcolemmal channels through...
Heart failure is a growing epidemic, with systemic hypertension major risk factor for development of disease. However, the molecular determinants that prevent transition from state hypertensive load to overt cardiac remain largely unknown. Here in experimental hypertension, knockout KCNJ11 gene, encoding Kir6.2 pore-forming subunit sarcolemmal ATP-sensitive potassium (K ATP ) channel, predisposed heart and death. Defective decoding hypertension-induced metabolic distress signals K channel...
Abstract Pathogenic causes underlying nonischemic cardiomyopathies are increasingly being resolved, yet repair therapies for these commonly heritable forms of heart failure lacking. A case in point is human dilated cardiomyopathy 10 (CMD10; Online Mendelian Inheritance Man #608569), a progressive organ dysfunction syndrome refractory to conventional and linked mutations cardiac ATP-sensitive K+ (KATP) channel subunits. Embryonic stem cell therapy demonstrates benefit ischemic disease, but...
Sepsis, the systemic inflammatory response to infection, imposes a high demand for bodily adaptation, with cardiovascular key determinant of outcome. The homeostatic elements that secure cardiac tolerance in setting sepsis syndrome are poorly understood. Here, model acute septic shock induced by endotoxin challenge Escherichia coli lipopolysaccharide (LPS), knockout KCNJ8 gene encoding vascular Kir6.1 K(ATP) channel pore predisposed an early and profound survival disadvantage. exaggerated...
The main cause of pulpal and periapical diseases is bacterial infection, but mechanical chemical preparation in root canal therapy difficult to completely remove the microorganism. Antibacterial photodynamic (aPDT) a medical method that kills microorganisms by activating photoactive agent or photosensitizer exposure visible light specific wave-length presence oxygen. present study aimed evaluate killing vitro effect aPDT with 0.01% methylene blue (MB) against young mature Enterococcus...
Randomized controlled trials (RCTs) provide the highest level of clinical evidence but are often limited by cost, time, and ethical constraints. Emulating RCTs using real-world data (RWD) offers a complementary approach to evaluate treatment effect in real setting. This study aims replicate based on Mayo Clinic Platform (MCP) electronic health records (EHRs) emulation frameworks. In this study, we address two key questions: (1) whether can be feasibly replicated MCP, (2) trial produces...
Metabolic-sensing ATP-sensitive K+ channels (KATP channels) adjust membrane excitability to match cellular energetic demand. In the heart, KATP channel activity has been linked homeostatic shortening of action potential under stress, yet requirement function in securing cardiac electrical stability is only partially understood. Here, upon catecholamine challenge, disruption channels, by genetic deletion pore-forming Kir6.2 subunit, produced defective shortening, predisposing myocardium early...
Abnormal expression of human myotonic dystrophy protein kinase (hDMPK) gene products has been implicated in type 1 (DM1), yet the impact distress accumulation produced by persistent overexpression this poorly understood member Rho kinase-related gene-family remains unknown. Here, aged transgenic murine line carrying approximately 25 extra copies a complete hDMPK with all exons and an intact promoter region (Tg26-hDMPK), mRNA transgene cardiac, skeletal smooth muscles resulted deficient...
China has an estimated 5 million people with tuberculosis (TB). Official policy is that treatment of all patients directly observed by health workers; completion rates are reported to be in excess 90%, and drugs should supplied for free. However, some research suggests there a gap between the official policies practice.Survey TB four counties one municipality; record assessment at centre; patient village doctor in-depth interviews.Sixteen per cent (64/401) being every time they took...