A5101733338- Influenza Virus Research Studies
- SARS-CoV-2 and COVID-19 Research
- Immune Response and Inflammation
- Advanced Authentication Protocols Security
- RNA modifications and cancer
- Plant Stress Responses and Tolerance
- Photosynthetic Processes and Mechanisms
- vaccines and immunoinformatics approaches
- Lipid metabolism and biosynthesis
- Ovarian cancer diagnosis and treatment
- Pneumonia and Respiratory Infections
- Security in Wireless Sensor Networks
- Peanut Plant Research Studies
- Animal Virus Infections Studies
- Poxvirus research and outbreaks
- Herpesvirus Infections and Treatments
- Viral Infections and Outbreaks Research
- Ubiquitin and proteasome pathways
- Respiratory viral infections research
- COVID-19 Clinical Research Studies
- Forest, Soil, and Plant Ecology in China
- Viral gastroenteritis research and epidemiology
- Cryptography and Data Security
- Bacillus and Francisella bacterial research
- Advanced Computational Techniques and Applications
Wuhan Institute of Bioengineering
2011-2024
Hainan University
2024
Shandong Academy of Agricultural Sciences
2006-2023
China National Biotechnology (China)
2021-2023
Zhejiang Center for Disease Control and Prevention
2022
First Hospital of China Medical University
2021
China Medical University
2021
Harrison International Peace Hospital
2020
Ministry of Agriculture and Rural Affairs
2019
Commonwealth Scientific and Industrial Research Organisation
2014-2016
Since May 2022, mutant strains of mpox (formerly monkeypox) virus (MPXV) have been rapidly spreading among individuals who not traveled to endemic areas in multiple locations, including Europe and the United States. Both intracellular extracellular forms outer membrane proteins that can stimulate immune response. Here, we investigated immunogenicity MPXV structural such as A29L, M1R, A35R, B6R a combination vaccine, protective effect against 2022 strain was also evaluated BALB/c mice. After...
The molecular mechanisms involved in plant tolerance to either drought or cold have been extensively studied many species. However, few studies focused on their comparisons especially using non-model plants with strong both stresses. Ammopiptanthus mongolicus (Maxim. ex Kom.) Cheng f. is the only evergreen broadleaf shrub grown central Asian desert and it has very tolerance. To provide further insights into tolerance, transcriptome profiles of drought- cold-treated A. seedlings were analyzed...
Since May 2022, human mpox cases have increased unexpectedly in non-endemic countries. The first imported case of Hong Kong was reported September 2022. Here we report the isolation and identification MPXV from vesicle swabs this patient. In research, were inoculated Vero E6 cells. addition to observing cytopathic effects (CPEs) or cells, isolated virus identified as (MPXV) using quantitative Real-Time PCR (RT-PCR), transmission electron microscopy, high-throughput sequencing. experiment...
The coronavirus SARS-CoV-2 has mutated quickly and caused significant global damage. This study characterizes two mRNA vaccines ZSVG-02 (Delta) ZSVG-02-O (Omicron BA.1), associating heterologous prime-boost strategy following the prime of a most widely administrated inactivated whole-virus vaccine (BBIBP-CorV). induces neutralizing antibodies that effectively cross-react with Omicron subvariants. In naïve animals, or induce humoral responses skewed to vaccine's targeting strains, but...
Vaccination remains the best prevention strategy against influenza. The MDCK-based influenza vaccine prompted development of innovative cell culture manufacturing processes. In present study, we report effects multiple administrations a candidate, seasonal, MDCK-based, quadrivalent split virus MDCK-QIV in Sprague-Dawley (SD) rats. Moreover, were evaluated terms fertility and early embryonic development, embryo-fetal perinatal toxicity SD rats immunogenicity Wistar BALB/c mice. Regarding...
A randomized, double-blind, placebo-controlled multicenter trial was conducted in healthy Chinese infants to assess the efficacy and safety of a hexavalent live human-bovine reassortant rotavirus vaccine (HRV) against gastroenteritis (RVGE). total 6400 participants aged 6-12 weeks were enrolled randomly assigned either HRV (n = 3200) or placebo group. All subjects received three oral doses four apart. The (VE) RVGE caused by serotypes contained evaluated from 14 days after administration...
孟德云 1,2,3 侯林琳 2,3,4 杨 莎 2,3 孟静静 郭 峰 李新国 2,3* 万书波 3* 1 山东大学生命科学学院, 济南 250100; 2 山东省农业科学院生物技术研究中心, 3 山东省作物遗传改良与生态生理重点实验室, 4 青岛农业大学农学与植物保护学院, 青岛 266109
Intracranial aneurysm (IA) is vascular enlargement occurred on the wall of cerebral vessels and can result in fatal subarachnoid hemorrhage when ruptured. Recent studies have supported important role long non-coding RNAs (lncRNAs) IA treatment. This study identified functional significance lncRNA myocardial infarction associated transcript (MIAT) IA. Myocardial ectodermal-neural cortex 1 (ENC1) expression was detected by reverse transcription quantitative polymerase chain reaction. Cell...
This phase III clinical trial aimed to assess the safety and demonstrate immunogenicity of a candidate freeze-dried purified Vero cell-based rabies vaccine (PVRV-WIBP) developed for human use. A cohort 40 participants in stage 1 1956 subjects 2 with an age range 10–50 years were recruited trial. For analysis 1, 20 received either 4-dose or 5-dose regimen PVRV-WIBP. In 2, randomly divided into PVRV-WIBP, PVRV-LNCD, PVRV-WIBP groups. The serum neutralizing antibody titer against was determined...
Background A quadrivalent split influenza vaccine IIV4-W against both and B viruses is urgently needed.Methods To evaluate the safety immunogenicity of in people aged 3–60 years, 2400 participants recruited a double-blind phase III trial were randomly assigned to IIV4-W, TIV1 TIV2 groups. The indicators measured at 28 days postvaccination for 180 follow-up.Results Adverse events (AEs) occurred 162 (20.28%), 116 (14.55%) 123 (15.41%) groups, respectively. All these AEs mild self-limiting, no...
万书波 1,2* 1 山东省农业科学院生物技术研究中心, 济南 250100; 2 山东省作物遗传改良与生态生理重点实验室, 3 山东省文登市农业技术推广站, 山东威海 26400 摘 要 以花生(Arachis hypogaea)品种'花育22号'为研究材料, 2013年在威海文登市、2014年在日照三庄镇的丘陵砂壤土上 进行试验, 研究增施钙肥对酸性土花生的产量、品质的影响, 以及相关碳、氮代谢酶活性差异, 探讨酸性土花生钙肥最佳用 量。试验设3个钙肥处理, 分别为每667 m 施CaO 0 kg (T )、14 )、28 )。结果表明: 酸性土增施钙肥显著增加了花 生的荚果产量, 两个试验点T 处理平均增产26.92%,T 处理平均增产21.65%。增产原因是增施钙肥显著增加了花生单株结果数, 提高了双仁果率, 从而增加了单株荚果产量, 同时增加了籽仁的饱满度而显著提高了出仁率。钙肥处理均显著提高了花 生籽仁蛋白质和脂肪含量, 提高了赖氨酸、总氨基酸含量和油酸/亚油酸(O/L)比值。酸性土增施钙肥显著提高了花生叶片的...
To control seasonal influenza epidemics in elders, a quadrivalent, inactivated, split-virion vaccine (IIV4) comprising A and B lineages is produced for young individuals adults aged ≥60 years. In this phase III, randomized, double-blind, active-controlled trial, we compared safety immunogenicity of IIV4 with licensed quadrivalent inactivated (IIV4-HL) by Hualan Biological Engineering during the 2019 season. Participants were randomly assigned to receive (n = 959) or IIV4-HL 959). Compared...
The immunity of patients who recover from coronavirus disease 2019 (COVID-19) could be long lasting but persist at a lower level. Thus, recovered still need to vaccinated prevent reinfection by severe acute respiratory syndrome 2 (SARS-CoV-2) or its mutated variants. Here, we report that the inactivated COVID-19 vaccine can stimulate in maintain high levels anti-receptor-binding domain (RBD) and anti-nucleocapsid protein (NP) antibody titers within 9 months, neutralizing activity against...
The emergence of SARS-CoV-2 variants concern (VOCs) with increased transmissibility and partial resistance to neutralization by antibodies has been observed globally. There is an urgent need for effective vaccine combat these variants. Our study demonstrated that the B.1.351 variant inactivated candidate (B.1.351V) generated strong binding neutralizing antibody responses in BALB/c mice against virus other after two doses within 28 days. Immunized K18-hACE2 also exhibited elevated levels live...
The resurgence of pertussis in vaccinated communities may be related to the reduced long-term immunity induced by acellular vaccines. Therefore, developing improved vaccine candidates that could induce strong Th1 or Th17 cellular is an urgent need. use new adjuvants well meet this requirement. In research, we developed a novel adjuvant candidate combining liposome and QS-21 adjuvant. Adjuvant activity, protective efficacy, level neutralizing antibody against PT, resident memory T (TRM) cells...
Abstract Background Polyadenylation is an important mechanism by which mRNA molecules are terminated at their 3′-ends. Alternative polyadenylation (APA) can produce multiple transcripts from the same locus with different sites (PASs) and result in several 3′ untranslated regions (UTRs) varying length composition. APA affects approximately 60–70% of eukaryotic genes, fundamental consequences on cell proliferation, differentiation, tumorigenesis. Results In this study, we performed long-read,...