A5090641800- Pneumonia and Respiratory Infections
- Photosynthetic Processes and Mechanisms
- Microbial Inactivation Methods
- Probiotics and Fermented Foods
- Plant Stress Responses and Tolerance
- Genetic Mapping and Diversity in Plants and Animals
- Genetics and Plant Breeding
- Enzyme Production and Characterization
- Carbohydrate Chemistry and Synthesis
- Mosquito-borne diseases and control
- Autophagy in Disease and Therapy
- CRISPR and Genetic Engineering
- GABA and Rice Research
- Glycosylation and Glycoproteins Research
- Herpesvirus Infections and Treatments
- Toxoplasma gondii Research Studies
- Vitamin D Research Studies
- 14-3-3 protein interactions
- Gut microbiota and health
- Immunotherapy and Immune Responses
- Infections and bacterial resistance
- Heavy Metals in Plants
- Vitamin C and Antioxidants Research
- Advanced oxidation water treatment
- Plant Micronutrient Interactions and Effects
China National Rice Research Institute
2020-2025
Chinese Academy of Agricultural Sciences
2016-2025
First Affiliated Hospital of Zhengzhou University
2023-2024
Qingdao Agricultural University
2023-2024
Nanjing Normal University
2023
Zhejiang Provincial People's Hospital
2023
Zhengzhou University
2023
Hebei University of Science and Technology
2020-2022
Harbin Veterinary Research Institute
2016-2022
Luoyang Normal University
2020-2022
Introduction Pneumonia are the leading cause of death worldwide, and antibiotic treatment remains fundamental. However, conventional sputum smears or cultures still inefficient for obtaining pathogenic microorganisms.Metagenomic next-generation sequencing (mNGS) has shown great value in nucleic acid detection, however, NGS results lower respiratory tract microorganisms poorly studied. Methods This study dealt with investigating efficacy mNGS detecting pathogens patients pulmonary infections....
Sucrose laurate (SL) is a dual-functional additive with emulsifying and antibacterial activities. The synergistic mechanism of SL nisin were studied against Staphylococcus aureus. Alkaline phosphatase peptidoglycan assays showed that could synergistically disrupt the integrity cell wall by blocking synthesis peptidoglycan. Fluorescence spectroscopy flow cytometry analysis revealed depolarized membrane potential, inhibited Na+K+ Ca2+Mg2+-ATPase activities on membrane, triggered K+ leakage,...
Summary Improving nitrogen use efficiency (NUE) in rice is a requirement for future sustainable agricultural production. However, key factors and regulatory networks involved NUE remain unclear. Here, QTL analysis, fine‐mapping functional validation demonstrated that qCR4 encodes putative high‐affinity nitrate transporter‐activating protein 2.2 (OsNAR2.2). Located the endoplasmic reticulum (ER), OsNAR2.2 was confirmed to regulate transport from root‐to‐shoot control panicle number, grain...
Global warming threatens rice growth and reduces yields. Proline plays important roles in plant abiotic stress tolerance. Previous research demonstrated that engineering proline metabolism-related genes can enhance tolerance to freezing salinity Arabidopsis. OsProDH encodes a putative dehydrogenase is single copy gene rice. However, whether remains unknown.Quantitative RT-PCR analysis revealed transcript contents were relatively higher leaf blade root tissues the high temperature treatment...
Abstract Jujube ( Ziziphus jujuba Mill.) is an important perennial fruit tree with a range of interesting horticultural traits. It was domesticated from wild jujube acidojujuba ), but the genomic variation dynamics and genetic changes underlying its traits during domestication are poorly understood. Here, we report comprehensive genome map based on resequencing 350 accessions, including wild, semi-wild cultivated plants, at >15× depth. Using combination genome-wide association study...
Abstract A large number of studies have demonstrated that autophagy is involved in the infection processes different pathogens. Autophagy now recognized as an essential component innate and adaptive immunity. Several herpesviruses developed various strategies to evade this antiviral mechanism. Pseudorabies virus (PRV) a swine herpesvirus with broad host range causes devastating disease infected pigs. In study, we described interaction between PRV for first time. had dual effect on cell...
Abstract Background Severe acute respiratory infection (SARI), a significant global health concern, imposes substantial disease burden. In China, there is inadequate data concerning the monitoring of pathogens, particularly bacteria, among patients with SARI. Therefore, this study aims to delineate demographic, epidemiological, and aetiological characteristics hospitalised SARI in Central China between 2018 2020. Methods Eligible admitted First Affiliated Hospital Zhengzhou University 1...
Leaf shape is an important agronomic trait for constructing ideal plant type in rice, and high-density genetic map facilitative improving accuracy efficiency quantitative loci (QTL) analysis of leaf trait. In this study, a contained 10,760 specific length amplified fragment sequencing (SLAF) markers was established based on 149 recombinant inbred lines (RILs) derived from the cross between Rekuangeng (RKG) Taizhong1 (TN1), which exhibited 1,613.59 cM distance with average interval 0.17 cM. A...
Both autophagy and apoptosis are mechanisms that maintain homeostasis in cells play essential roles viral infections. Previous studies have demonstrated pathways occurred with complex relationships virus-infected cells. However, the regulation between these two processes Pseudorabies virus (PRV) infection remains unclear. In present study, we activated was induced at early stage of PRV late infection. Autophagy induction inhibited decreased replication, inhibition promoted increased...
Abstract Senescence in plants is induced by endogenous physiological changes and exogenous stresses. In this study, we isolated two alleles of a novel rice (Oryza sativa) mutant, yellow premature dwarf 1 (ypd1). The ypd1 mutants exhibited phenotype from germination, senescence starting at tillering. Moreover, the were sensitive to high light, which accelerated cell death senescence. Consistent with their phenotype, had abnormal chloroplasts lower levels photosynthetic pigments. TUNEL assays...
Grain size is an important agronomic trait determines yield in barley, and a high-density genetic map helpful to accurately detect quantitative loci (QTLs) related grain traits. Using specific-locus amplified fragment sequencing (SLAF-seq) technology, was constructed with population of 134 recombinant inbred lines (RILs) deriving from cross between Golden Promise (GP) H602, which contained 12,635 SLAFs 26,693 SNPs, spanned 896.74 cM average interval 0.07 on seven chromosomes. Based the map,...
ζ-carotene desaturase (ZDS) is a key enzyme in carotenoid biosynthesis and plays an important role plant photosynthesis. We characterized albino leaf-color mutant obtained from ethyl methanesulfonate treatment: seedling lethality 1 (ale1). The material contains chloroplast thylakoid defect where photosynthetic pigments declined reactive oxygen species accumulated resulting ale1 death within 3 weeks. Positional cloning sequencing revealed that there was single base substitution ALE1, which...
Abstract Cas1-and-Cas2-mediated new spacer acquisition is an essential process for bacterial adaptive immunity. The critical the ecology of oral microflora and health. Although molecular mechanisms are known, it has never been established if this associated with morphological changes bacteria. In study, we demonstrated a novel Cas2-induced filamentation phenotype in E. coli that was regulated by co-expression Cas1 protein. A 30 amino acid motif at carboxyl terminus Cas2 necessary function....
Grain size is a determinant of rice grain yield. In plants, mitochondria supply energy for cellular metabolism via the mitochondrial electron transport chain. Here we report that OsNDB2, which encodes putative rotenone-insensitive type II NAD(P)H dehydrogenase (ND), negatively regulates and weight in rice. Six ND members representing three major types were identified, predicted OsNDB2 protein was localized to mitochondria. Contents transcripts higher young panicles leaf blades....