A5048839080- Ion channel regulation and function
- Neuroscience and Neuropharmacology Research
- Analytic Number Theory Research
- Cardiac electrophysiology and arrhythmias
- Nitric Oxide and Endothelin Effects
- Lipid Membrane Structure and Behavior
- Immune Cell Function and Interaction
- Advanced Algebra and Geometry
- Connexins and lens biology
- HIV Research and Treatment
- Neuroscience and Neural Engineering
- Immunotherapy and Immune Responses
- Hydrocarbon exploration and reservoir analysis
- Viral Infections and Immunology Research
- Magnetic and Electromagnetic Effects
- Higher Education and Teaching Methods
- Geophysical and Geoelectrical Methods
- Light effects on plants
- Antiplatelet Therapy and Cardiovascular Diseases
- Renin-Angiotensin System Studies
- Signaling Pathways in Disease
- Nicotinic Acetylcholine Receptors Study
- Cardiovascular and exercise physiology
- Electrochemical Analysis and Applications
- Parallel Computing and Optimization Techniques
Tianjin Medical University General Hospital
2024
Xiamen University
2012-2023
Hainan Medical University
2023
Xinjiang Production and Construction Corps
2023
Chongqing University
2023
Shandong University
2013-2023
Inner Mongolia University
2022-2023
Zhejiang University
2023
Nankai University
2014-2023
China University of Petroleum, East China
2023
Cell adhesion to extracellular matrix components such as fibronectin has a complex basis, involving multiple determinants on the molecule that react with discrete cell surface macromolecules. Our previous results have demonstrated normal and transformed cells adhere spread 33-kD heparin binding fragment originates from carboxy-terminal end of particular isoforms (A-chains) human fibronectin. This promotes melanoma spreading in an arginyl-glycyl-aspartyl-serine (RGDS) independent manner,...
It is well known that dimethyl sulphoxide (DMSO) increases membrane permeability, which makes it widely used as a vehicle to facilitate drug delivery across biological membranes. However, the mechanism of how DMSO permeability has not been understood. Recently, molecular dynamics simulations have demonstrated can induce water pores in membranes, but no direct experimental evidence so far available prove simulation result. Using FluxOR Tl+ influx assay and intracellular Ca2+ imaging...
Family members of peroxisome proliferator-activated receptors (PPARs), such as PPARγ, have been shown to be effective in regulating T helper 17 (Th17) cell differentiation. However, whether PPARα, another important family member PPARs, contributes Th17 differentiation remains controversial. In the present study, we show that PPARα may a negative regulator CD4+ cells from knockout mice, deficiency enhances IL-17 and IL-6 levels promotes contrast, wild type activation suppresses Furthermore,...
Diabetic nephropathy (DN) is one of the serious chronic microvascular complications diabetes, and leads to increased morbidity mortality in diabetic patients. Gasdermin E (GSDME)-dependent pyroptosis signaling pathway plays important roles a variety physiological pathological processes. However, its role mechanism DN are still unclear. In this study, we established rat model by intraperitoneal injection streptozotocin (STZ) successfully. Structural functional disorders kidney were exhibited...
Mechanosensitive ion channels are expected to play important roles in transducing mechanical stimuli into intracellular signals during the development and morphogenesis of higher plants. We have identified a novel mechanosensitive anion channel protoplast Arabidopsis thaliana mesophyll cells by using patch-clamp technique. The outside-out patches could be activated positive pressure pipette while negative had no effect. amphipathic membrane crenator trinitrophenol, which is supposed...
Some BK channels are activated in response to membrane stretch. However, it remains largely unknown which component transmits forces the channel and part of senses force. Recently, we have shown that a cloned from chick heart (named SAKCa channel) is stretch channel, while deletion 59 amino acids splice insert (STREX) located cytoplasmic side, abolishes its stretch-sensitivity. This finding raised question whether stress bilayer crucial for mechanical activation channel. To address this...
Extensive data have shown that exercise training can provide cardio-protection against pathological cardiac hypertrophy. However, how long the heart retain cardio-protective phenotype after cessation of is currently unknown. In this study, we investigated time course loss and signaling molecules are responsible for possible sustained protection. Mice were made to run on a treadmill six times week 4 weeks then rested period 0, 1, 2 followed by isoproterenol injection 8 days. Morphological,...
Stroke is a long-term disability and one of the leading causes death. However, no successful therapeutic intervention available for majority stroke patients. In this study, we explored traditional Chinese medicine Baifuzi (Typhonium giganteum Engl.). We show, at first, that ethanol extract exerts neuroprotective effects against brain damage induced by transient global or focal cerebral ischemia in rats mice. Second, activated large-conductance Ca(2+)-activated K(+) channel (BK(Ca)) channels,...
Abstract Prolongation of QRS duration in electrocardiogram is one the risk factors for morbidity and mortality many kinds cardiac diseases. However, its molecular mechanism unknown. In this study, utilizing experimental autoimmune myocarditis ( EAM ) as a disease model, we show that prolongation accompanied by elevated phosphorylation connexin 43 (Cx43) at Ser368 p S 368 Cx43). cultured cells, inflammatory cytokine IL ‐1β activates p38 MAPK to up‐regulate Cx43 impairs cell‐to‐cell...
Changes in the cholesterol levels dynamically alter microenvironment of plasma membrane and have been shown to modify functions ion channels. However, cellular effect these modifications is largely unknown. In this report, we demonstrate that modulate neuronal excitability rat hippocampal neurons. Reduction shortened duration increased firing frequency peak amplitude action potentials, while enrichment reversed effect. Furthermore, showed reduction increased, decreased delayed rectifier IK...
S100A7 is highly expressed in squamous cell carcinomas (SCC) and related to the terminal differentiation of keratinocytes. However, its characteristic function SCC not very known. In this present study, we used immunohistochemistry examine expression 452 specimens, including lung, esophagus, oral cavity, skin, cervix, bladder, three lines. We found that S100A7-positive staining showed significant heterogeneity six types specimen Further examination cells at mRNA protein levels could be...
<b><i>Objective:</i></b> Exercise training (ET) provides a cardioprotective effect against pathological cardiac hypertrophy. Nitric oxide (NO) plays an important role in modulating However, few studies explore the relationship between NO signaling and inhibitory of ET on remodeling. <b><i>Methods:</i></b> In this study, we evaluated effects isoproterenol (ISO)-induced hypertrophy female mice. Moreover,<smlcap> L</smlcap>-NAME...
The purpose of this study was to investigate the effect platelet-rich plasma on proliferation osteoblasts and tenocytes in tendon-bone healing. We cultured an indirect coculture system with Transwell filters (Merck Millipore, Billerica, Massachusetts). examined using Cell Counting Kit-8 (Dojindo Chemistry Research Institute, Kumamoto, Japan).Four groups were studied: group 1, one cell type without plasma; 2, two types together 3, cells outer chamber inner chamber; 4, different each 2...