A5101923387- Neural dynamics and brain function
- Sepsis Diagnosis and Treatment
- Proteoglycans and glycosaminoglycans research
- Neuroscience and Music Perception
- Immune Response and Inflammation
- Acute Kidney Injury Research
- Diabetes Treatment and Management
- Glycosylation and Glycoproteins Research
- Metabolism, Diabetes, and Cancer
- Diabetes Management and Research
- Chronic Kidney Disease and Diabetes
- Pancreatic function and diabetes
- Cell Adhesion Molecules Research
- Advanced Glycation End Products research
- Palliative Care and End-of-Life Issues
- Neural Networks and Applications
- Dialysis and Renal Disease Management
- Respiratory Support and Mechanisms
- Neonatal Respiratory Health Research
- Visual perception and processing mechanisms
- Voice and Speech Disorders
- Blind Source Separation Techniques
- Cancer survivorship and care
- Protease and Inhibitor Mechanisms
- Trauma, Hemostasis, Coagulopathy, Resuscitation
RAND Corporation
2012-2025
Amsterdam University Medical Centers
2021-2024
Vrije Universiteit Amsterdam
2021-2024
University of California, San Francisco
2018-2022
St. Michael's Hospital
2009-2022
University of Toronto
2011-2022
Alberta Health Services
2022
University of Alberta
2022
Public Health Ontario
2022
Pharmaceutical Product Development (United States)
2022
To understand the neural representation of broadband, dynamic sounds in primary auditory cortex (AI), we characterize responses using spectro-temporal response field (STRF). The STRF describes, predicts, and fully characterizes linear dynamics neurons to with rich envelopes. It is computed from elementary "ripples," a family drifting sinusoidal spectral collection all ripples transfer function. complex envelope any sound can expressed as sum individual ripples. Previous experiments downward...
Readmission rates are used as an indicator of the quality care that patients receive during a hospital admission and after discharge.To determine prevalence pediatric readmissions magnitude variation in readmission across hospitals.We analyzed 568,845 admissions at 72 children's hospitals between July 1, 2009, June 30, 2010, National Association Children's Hospitals Related Institutions Case Mix Comparative data set. We estimated hierarchical regression models for 30-day by hospital,...
Polymyxin B hemoperfusion reduces blood endotoxin levels in sepsis. Endotoxin activity can be measured with a rapid assay. Treating patients septic shock and elevated using polymyxin may improve clinical outcomes.To test whether adding to conventional medical therapy improves survival compared alone among high activity.Multicenter, randomized trial involving 450 adult critically ill an assay level of 0.60 or higher enrolled between September 2010 June 2016 at 55 tertiary hospitals North...
The metastatic spread of tumor cells occurs through a complex series events, one which involves the adhesion to extracellular matrix (ECM) components. Multiple interactions between cell surface receptors an adherent and surrounding ECM contribute motility invasion. current studies evaluate role chondroitin sulfate proteoglycan (CSPG) in adhesion, motility, invasive behavior highly mouse melanoma line (K1735 M4) on type I collagen matrices. By blocking production CSPG with p-nitrophenyl...
Objective: Second-generation, or atypical, antipsychotics effectively treat psychiatric illness in children and adolescents. However, weight gain abnormalities insulin sensitivity, including diabetes, complicate this therapy. Method: A 16-week double-blind, placebo-controlled trial was conducted to evaluate the effectiveness of metformin managing 39 subjects, ages 10–17, whose had increased by more than 10% during less 1 year olanzapine, risperidone, quetiapine Body weight, body mass index...
Periodicity pitch is the most salient and important of all percepts. Psychoacoustical models this percept have long postulated existence internalized harmonic templates against which incoming resolved spectra can be compared, determined according to best matching [J. Goldstein, J. Acoust. Soc. Am. 54, 1496–1516 (1973)]. However, it has been a mystery where how such come about. We present here biologically plausible model for form in early stages auditory system. The demonstrates that any...
Recent work suggests that the normal barrier to penetration of renal glomerular basement membrane by anionic plasma proteins may depend in part on existence negatively charged sites within membrane. We describe an vitro cytochemical method for quantitative demonstration human In five subjects, ranging age from 10 days 57 years, were distributed at regular intervals lamina rara externa, with a frequency 23.8±6.8 per 1000-nm length A similar distribution was observed membranes three fetuses....
Septic shock is common and has unacceptably high morbidity, mortality, associated cost with numerous failed attempts at developing effective therapies. Endotoxin, one of the most potent mediators sepsis, found in levels approximately 50% patients septic shock. Polymyxin B (PMX) hemoperfusion been shown studies to successfully remove endotoxin potentially improve outcomes. EUPHRATES (Evaluating Use Hemoperfusion a Randomized controlled trial Adults Treated for Endotoxemia shock) theragnostic...
Although single units in primary auditory cortex (A1) exhibit accurate timing their phasic response to the onset of sound (precision a few milliseconds), paradoxically, they are unable sustain synchronized responses repeated stimuli at rates much beyond 20 Hz. To explore relationship between these two aspects cortical response, we designed broadband stimulus with slowly modulated spectrotemporal envelope riding on top rapidly waveform (or fine structure). Using this stimulus, quantified...
Cell adhesion to extracellular matrix components such as fibronectin has a complex basis, involving multiple determinants on the molecule that react with discrete cell surface macromolecules. Our previous results have demonstrated normal and transformed cells adhere spread 33-kD heparin binding fragment originates from carboxy-terminal end of particular isoforms (A-chains) human fibronectin. This promotes melanoma spreading in an arginyl-glycyl-aspartyl-serine (RGDS) independent manner,...
Background: The prevalence of type 2 diabetes (T2D) in youth is increasing. Treatment options beyond metformin and insulin are needed. safety, tolerability, pharmacokinetics, pharmacodynamics liraglutide once daily (10–17 years old) with T2D were investigated a randomized, double-blind, placebo-controlled trial. Subjects Methods: Youth treated diet/exercise alone or having hemoglobin A1c (HbA1c) level 6.5–11% randomized to (n=14) placebo (n=7). Starting at 0.3 mg/day, doses escalated weekly...
Background: Glycated hemoglobin (HbA1c) and measures of short-term glycemia do not fully capture daily patterns in plasma glucose dynamics. This study evaluated 24-h glycemic profiles patients with type 2 diabetes (T2D) initiated on dapagliflozin treatment using continuous monitoring (CGM). Methods: randomized double-blind placebo-controlled multicenter parallel-design 4-week compared (10 mg/d; n = 50) placebo (n adult T2D uncontrolled (HbA1c 7.5%–10.5%) either stable doses metformin...
Background. The metabolic syndrome, associated with increased risk of type 2 diabetes mellitus and cardiovascular disease, begins to develop during adolescence. Objective. We sought identify early predictors the presence syndrome at ages 18 19 years in black white girls. Methods. Using longitudinal data on participants from centers National Heart, Lung, Blood Institute Growth Health Study, a 10-year cohort study, we applied cutoffs Adult Treatment Panel III document changes prevalence...
This paper examines the links between individual adolescent smoking behavior and actual perceived in individual's school cohort. We hypothesized that students enrolled schools with higher prevalence among their grade are more likely to smoke subsequently. also expected school-level of have a greater impact than because former is direct measure norms. Adjusting for demographics, at baseline (grade 7) was strongly associated frequency one year later. However, association disappeared after...
35S-glycosaminoglycan metabolism by glomeruli isolated from streptozotocin-diabetic and control rats was studied in vivo vitro. Total synthesis retention the matrix diabetic reduced while degradation increased. content of GBM similarly decreased. Whereas decreased after vitro incubation with 35SO4, a larger proportion total 35S-glycosaminoglycans found medium glomeruli. Both synthesize 35S-labeled glycopeptides, quantity being reduced. Aorta 35SO4-injected also synthesized quantities...