A5101580515- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Extracellular vesicles in disease
- RNA Research and Splicing
- Cancer-related gene regulation
- RNA and protein synthesis mechanisms
- Peptidase Inhibition and Analysis
- Microtubule and mitosis dynamics
- Wnt/β-catenin signaling in development and cancer
- Cancer Mechanisms and Therapy
- Ubiquitin and proteasome pathways
- Autophagy in Disease and Therapy
- Reproductive System and Pregnancy
- Cancer Cells and Metastasis
- Epigenetics and DNA Methylation
- interferon and immune responses
- Mitochondrial Function and Pathology
- Phagocytosis and Immune Regulation
- Bone Metabolism and Diseases
- Erythrocyte Function and Pathophysiology
- Mechanisms of cancer metastasis
- Cytokine Signaling Pathways and Interactions
- Kruppel-like factors research
Zhejiang Chinese Medical University
2024-2025
Southern Medical University
2025
Nanfang Hospital
2025
Nantong University
2025
Affiliated Hospital of Nantong University
2025
Shanghai University of Traditional Chinese Medicine
2025
First Affiliated Hospital of Wannan Medical College
2017-2024
Institute of Bioinformatics
2024
Hebei Medical University
2024
Nanjing Medical University
2024
Gliomas are the most common malignant primary brain tumours with a highly immunosuppressive tumour microenvironment (TME) and poor prognosis. Circular RNAs (circRNA), newly found type of endogenous noncoding RNA, characterized by high stability, abundance, conservation, have been shown to play an important role in pathophysiological processes TME remodelling various tumours.CircRNA sequencing analysis was performed explore circRNA expression profiles normal glioma tissues. The biological...
Abstract Exosomes can selectively secrete harmful metabolic substances from cells to maintain cellular homeostasis, and complex crosstalk occurs between exosomes tumor-associated macrophages (TAMs) in the glioma immune microenvironment. However, precise mechanisms by which these exosome-encapsulated cargos create an immunosuppressive microenvironment remain unclear. Herein, we investigated effect of glioma-derived (GDEs) on macrophage polarization progression. We performed sequencing...
Abstract Background Tumor-associated macrophages (TAMs), particularly M2-polarized TAMs, are significant contributors to tumor progression, immune evasion, and therapy resistance in gastric cancer (GC). Despite efforts target TAM recruitment or depletion, clinical efficacy remains limited. Consequently, the identification of targets that specifically inhibit reprogram TAMs presents a promising therapeutic strategy. Objective This study aims identify dual-function GC cells drives both...
The cytokines RANKL and TNF activate NF-κB signaling in osteoclast precursors (OCPs) to induce (OC) formation. Conversely, can limit OC formation through p100, which acts as an inhibitor, receptor–associated receptor 3 (TRAF3); however, a role for TRAF3 RANKL-mediated is unknown. We found that limits RANKL-induced osteoclastogenesis by suppressing canonical noncanonical signaling. Conditional OC-specific Traf3-KO (cKO) mice had mild osteoporosis increased induced degradation via the...
Abstract Glioma is the most common malignant tumor of central nervous system in adults. The microenvironment (TME) related to poor prognosis glioma patients. cells could sort miRNA into exosomes modify TME. And hypoxia played an important role this sorting process, but mechanism not clear yet. Our study was find miRNAs sorted and reveal process. Sequencing analysis patients cerebrospinal fluid (CSF) tissue showed that miR-204-3p tends be exosomes. suppressed proliferation through...
In Saccharomyces cerevisiae, 11 out of 42 tRNA species contain 5-methoxycarbonylmethyl-2-thiouridine (mcm5s2U), 5-methoxycarbonylmethyluridine (mcm5U), 5-carbamoylmethyluridine (ncm5U) or 5-carbamoylmethyl-2′-O-methyluridine (ncm5Um) nucleosides in the anticodon at wobble position (U34). Earlier we showed that mutants unable to form side chain 5 (ncm5 mcm5) lacking sulphur 2 (s2) U34 result pleiotropic phenotypes, which are all suppressed by overexpression hypomodified tRNAs. This...
Abstract Liquid biopsy is a novel strategy for tumour diagnosis. The contents of cerebrospinal fluid (CSF) exosomes could reflect glioma status, hence sampling from CSF means liquid glioma. However, few studies have focused on the function microRNAs in exosomes. In this study, we found that miR‐3184‐3p was enriched patients and downregulated after resection. We miR‐3184 facilitates progression two ways. On one hand, directly promotes proliferation, migration, invasion while inhibiting...
Background: Glioblastoma (GBM) is the most common primary brain malignancy and has high aggressiveness a poor prognosis.N6-methyladenosine (m6A) represents prevalent methylation modification of lncRNAs been shown to play important roles in pathophysiological processes tumors.However, distribution function m6A modifications GBM tissues have not fully revealed.Methods: The global depiction m6A-modified lncRNA expression patterns tumor was screened via high-throughput sequencing.Gain-and...
Extracellular vesicles (EVs) produced in the tumor microenvironment response to chemotherapy promote chemotherapy-resistant phenotypes. However, role of EVs proteins induced by gastric cancer (GC) cell regulating resistance remains unclear. Immunohistochemistry was used verify relationship between brain-specific angiogenesis inhibitor 1-associated protein-2-like protein 2 (BAIAP2L2) expression and advanced GC. The BAIAP2L2 verified using a subcutaneous model nude mice. Transmission electron...
MicroRNAs (miRNAs/miRs) have been revealed to influence the development and progression of glioblastoma. Although a number miRNAs are abnormally expressed in glioblastoma it is not clear whether they factor associated with pathogenesis. In present study, miR-7-5p was identified as being aberrantly downregulated tissues cell lines. overexpression significantly decreased migratory invasive capacity cells, while silencing had opposite effect. addition, luciferase assay confirmed that special AT...
14-3-3ζ has been reported to function as critical regulators of diverse cellular responses. However, the role in gliomas progression remains largely unknown. The expression level and Snail was detected by Western blot analysis quantitative polymerase chain reaction different grades human gliomas. effect on measured using cell migration invasion assay, colony formation experiment, CCK-8 assay. PI3K/AKT/Snail signaling protein levels tested blotting. Firstly, often up-regulated high-grade...
Calcium transients play an essential role in cardiomyocytes and electromagnetic fields (EMF) affect intracellular calcium levels many types of cells. Effects EMF on are not well studied. The aim this study was to assess whether extremely low frequency (ELF-EMF) could cardiomyocytes. Cardiomyocytes isolated from neonatal Sprague-Dawley rats were exposed rectangular-wave pulsed ELF-EMF at four different frequencies (15 Hz, 50 75 Hz 100 Hz) a flux density 2 mT. Intracellular concentration...
Hepatocellular carcinoma (HCC) is an aggressive cancer with a poor prognosis. The specific cellular gene alterations responsible for hepatocarcinogenesis are not well known. Previous works showed that loss of TIP30 , also called CC3 putative tumor suppressor, increased the incidence hepatocellular in mice, and some clinical samples human HCC tissues had aberrant expression . Here, we report introduction by adenovirus vector into cell lines decreased expressions inhibited proliferation,...
Although it is widely accepted that human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are readily available, robustly reproducible, and physiologically appropriate cells for clinical applications research in the cardiovascular field, hiPSC-CMs cultured vitro retain an immature metabolic phenotype limits their application, little known about underlying molecular mechanism controlling mitochondrial maturation during (hiPSCs ) differentiation into cardiomyocytes. In this...