A5061825997- Dendrimers and Hyperbranched Polymers
- RNA Interference and Gene Delivery
- Advanced Polymer Synthesis and Characterization
- Nanoparticle-Based Drug Delivery
- Antimicrobial agents and applications
- Plant nutrient uptake and metabolism
- Hydrogels: synthesis, properties, applications
- Nanoparticles: synthesis and applications
- Immunotherapy and Immune Responses
- Antimicrobial Peptides and Activities
- Advanced biosensing and bioanalysis techniques
- Protein Hydrolysis and Bioactive Peptides
- HVDC Systems and Fault Protection
- Power Systems and Renewable Energy
- Polysaccharides Composition and Applications
- Immune Cell Function and Interaction
- Plant Molecular Biology Research
- Proteins in Food Systems
- Food Quality and Safety Studies
- Medical Imaging Techniques and Applications
- Polysaccharides and Plant Cell Walls
- Microplastics and Plastic Pollution
- Advancements in Transdermal Drug Delivery
- Nanoplatforms for cancer theranostics
- Polymer Surface Interaction Studies
Jilin University
2023-2025
Xi'an Jiaotong University
2009-2025
China Agricultural University
2022-2024
State Key Laboratory of Electrical Insulation and Power Equipment
2024
Model Animal Research Center
2023-2024
China University of Petroleum, Beijing
2024
First Hospital of Jilin University
2024
Shenyang Agricultural University
2024
KTH Royal Institute of Technology
2016-2023
East China Normal University
2023
Many medical and chemical applications require target molecules to be delivered in a controlled manner at precise locations. Metal–organic frameworks (MOFs) have high porosity, large surface area, tunable functionality are promising carriers for such purposes. Current approaches incorporating based on multistep postfunctionalization. Here, we report novel approach that combines MOF synthesis molecule encapsulation one-pot process. We demonstrate drug dye can encapsulated zeolitic imidazolate...
The widespread production and use of nanoparticles calls for faster more reliable methods to assess their safety. main aim this study was investigate the genotoxicity three reference TiO2 nanomaterials (NM) within frame FP7-NANoREG project, with a particular focus on testing applicability mini-gel comet assay micronucleus (MN) scoring by flow cytometry. BEAS-2B cells cultured under serum-free conditions were exposed NM100 (anatase, 50-150nm), NM101 5-8nm) NM103 (rutile, 20-28nm) 3, 24 or 48h...
Abstract Biocompatible and degradable dual‐delivery gel systems based on hyperbranched dendritic−linear−dendritic copolymers (HBDLDs) is herein conceptualized accomplished via thiol‐ene click chemistry. The elasticity of the hydrogels tunable by varying lengths PEG (2, 6, 10 kDa) or dry weight percentages (20, 30, 40 wt%), are found to range from 2–14.7 kPa, comparable human skin. co‐delivery antibiotics achieved, where hydrophilic drug novobiocin sodium salt (NB) entrapped within hydrogel,...
Recently, chitosan has become attractive due to being biodegradable, biocompatible and renewable. However, the weak mechanical properties of films limit their large-scale application. In this work, a strategy blending TEMPO, oxidized CNF (TOCN) was developed fabricate nanocomposite in order improve maintain biocompatibility. The TOCN/chitosan exhibited excellent optical transmittance (>85%) extremely high tensile strength 235 MPa. good compatibility TOCN chains, dispersion aggregates...
Gene expression profiling has developed rapidly in recent years with the advent of deep sequencing technologies such as RNA (RNA Seq) and could be harnessed to predict define mechanisms toxicity chemicals nanomaterials. However, full potential these (nano)toxicology is yet realized. Here, we show that systems biology approaches can uncover underlying cellular responses Using Seq computational approaches, found cationic poly(amidoamine) dendrimers (PAMAM-NH2) are capable triggering...
Dendrimers and their less well-defined cousins, hyperbranched polymers, are widely investigated as scaffold materials in tissue engineering, drug delivery agents, diagnostic imaging applications. Despite the large interest of using these unique polymer-based nanoparticles biomedical applications, a clear understanding cellular uptake transport polyester-based is still lacking. The objective this study to evaluate profiles intracellular trafficking polymer micelles built from polyester...
Abstract The use of adhesives for fracture fixation can revolutionize the surgical procedures toward more personalized bone repairs. However, there are still no commercially available adhesive solutions mainly due to lack biocompatibility, poor strength, or inadequate protocols. Here, a surgically realizable system capitalizing on visible light thiol–ene coupling chemistry is presented. carefully designed and formulated from novel class chemical constituents influenced by dental resin...
DC series-parallel systems are a critical technology to the development of distant offshore wind power. However, most existing line protection methods suffer from restrictions when applying collection cables characterised by multiple interconnections and weak boundary features. To overcome limitations, this paper proposes unit method for clusters based on adaptive Spearman correlation coefficient (ASCC) line-mode current. Firstly, elaborates configuration system analyses its fault...
Histamine functionalized poly(allyl glycidyl ether)-
Amine functional polymers, especially cationically charged, are interesting biomacromolecules for several reasons, including easy cell membrane entrance, their ability to escape endosomes through the proton sponge effect, spontaneous complexation and delivery of drugs siRNA, simple functionalization in aqueous solutions. Dendrimers, a subclass precision monodisperse exhibit large exact number peripheral end groups relation size have shown promise drug delivery, biomedical imaging as...
Herein, we present the first evaluation of cationic dendrimers based on 2,2-bis(methylol)propionic acid (bis-MPA) as nonviral vectors for transfection short interfering RNA (siRNA) in cell cultures. The study encompassed generation one to four (G1⁻G4), modified bear 6⁻48 amino end-groups, where G2⁻G4 proved be capable siRNA complexation and protection against RNase-mediated degradation. were nontoxic astrocytes, glioma (C6), glioblastoma (U87), while G3 G4 exhibited concentration dependent...
A novel platform of dendritic nanogels is herein presented, capitalizing on the self-assembly allyl-functional polyesters based dendritic-linear-dendritic amphiphiles followed by simple cross-linking with complementary monomeric thiols via UV initiated off-stoichiometric thiol-ene chemistry. The facile approach enabled multigram creation allyl reactive nanogel precursors, in size range 190-295 nm, being readily available for further modifications to display a number core functionalities...
Eight fluorinated nanoparticles (NPs) are synthesized, loaded with doxorubicin (DOX), and evaluated as theranostic delivery platforms to breast cancer cells. The multifunctional NPs formed by self‐assembly of either linear or star‐shaped amphiphilic block copolymers, segments incorporated in the hydrophilic corona carrier. sizes confirm that small circular formed. release kinetics data particles reveals clear hydrophobic core dependence, longer sustained from larger cores, suggesting DOX...
Infections caused by antibiotic-resistant bacteria are globally a major threat, leading to high mortality rates and increased economic burden. Novel treatment strategies therefore urgently needed healthcare providers protect people. Biomaterials that have inherent antibacterial properties do not require the use of antibiotics present an attractive feasible avenue achieve this goal. Herein, we demonstrate effect new class cationic hydrogels based on amino-functional hyperbranched...
Abstract In our recent work, we have explored the formation of chemotherapeutic delivery vehicles constructed from four different amphiphilic linear‐dendritic hybrid block copolymers. These micelles were found to form about 100‐nm‐sized structures that capable sequestering doxorubicin at loading efficiencies up 22%. Here, cellular toxicity these biocompatible and biodegradable materials was evaluated on two breast cancer cell lines primary human macrophages. The not affect viability...
Redox-sensitive hyperbranched dendritic-linear polymers (HBDLPs) were prepared and stabilized individually as unimolecular micelles with diameters in the range 25-40 nm. The high molecular weight (500-950 kDa), core-shell amphiphilic structures synthesized through a combination of self-condensing vinyl copolymerization (SCVCP) atom transfer radical polymerization (ATRP). Cleavable disulfide bonds introduced, either backbone, or pendant groups, core HBDLPs. By triggered reductive degradation,...
A novel platform of fluorescently labeled nanocarriers (NCs) is herein proposed based on amphiphilic linear-dendritic polymeric hybrids. These sophisticated polymers were synthesized with a high degree structural control at macro-molecular level, displayed hydrophobic cholesterol compartments as chain-terminus groups the dendritic block and hydrophilic bifunctional linear poly(ethylene glycol) (PEG) block. Spherical supramolecular assemblies therapeutically relevant properties successfully...
Histamine functionalized block copolymers were prepared with different ratios of histamine and octyl or benzyl groups using UV-initiated thiol-ene click chemistry.
Abstract Hydrophobic agents, a fluorescent dye (Nile red, NR) or an anticancer drug (doxorubicin, DOX), are encapsulated into poly((N‐[3‐(dimethylamino) propyl] methacrylamide)‐ b ‐poly (methyl methacrylate) (PDMAPMA‐ ‐PMMA) nanoparticles (NPs) via one‐pot reversible addition‐fragmentation chain‐transfer (RAFT)‐mediated emulsion polymerization in water. The macroRAFT, PDMAPMA, is chain‐extended with the methyl methacrylate (MMA), hydrophobic agents soluble MMA, resulting loaded NPs, either...