A5075543736- Tuberculosis Research and Epidemiology
- Gestational Diabetes Research and Management
- Pregnancy and preeclampsia studies
- Mycobacterium research and diagnosis
- Viral Infections and Vectors
- Birth, Development, and Health
- Pneumocystis jirovecii pneumonia detection and treatment
- Thyroid Disorders and Treatments
- Air Quality and Health Impacts
- Urban Green Space and Health
- Animal Disease Management and Epidemiology
- Climate Change and Health Impacts
- Animal Virus Infections Studies
- Urban Heat Island Mitigation
- Single-cell and spatial transcriptomics
- Viral gastroenteritis research and epidemiology
- Diagnosis and treatment of tuberculosis
- Hypothalamic control of reproductive hormones
- Noise Effects and Management
- Cancer Cells and Metastasis
- Liver Disease Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Smoking Behavior and Cessation
- Homelessness and Social Issues
- Cardiovascular Issues in Pregnancy
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2025
Tianjin Municipal Research Institute for Family Planning
2021-2024
Chinese National Human Genome Center
2023
Peking Union Medical College Hospital
2022-2023
Hebei Medical University
2021
Evidence showed that air pollution was associated with an increased risk of tuberculosis (TB). This study aimed to the impact long-term exposure ambient particulate matter aerodynamic diameter less than 2.5 μm (PM2.5) on acquisition LTBI and subsequent active disease development among rural older adults from a multicentre cohort, which have not yet been investigated date. A total 4790 were included in population-based, multicenter, prospective cohort (LATENTTB-NSTM) 2013 2018. The level...
ABSTRACT Background Computer‐aided detection (CAD) software has been introduced to automatically interpret digital chest X‐rays. This study aimed evaluate the performance of CAD (JF CXR‐1 v3.0, which was developed by a domestic Hi‐tech enterprise) in tuberculosis (TB) case finding China. Methods In 2019, we conducted an internal evaluation JF v3.0 reading standard images annotated panel experts. 2020, using results X‐rays experts as reference standard, on‐site prospective and local...
Importance Maternal hepatitis B virus (HBV) infection during early pregnancy has been related to congenital heart diseases (CHDs) in offspring. However, no study date evaluated the association of maternal preconception HBV with CHDs Objective To explore Design, Setting, and Participants This retrospective cohort used nearest-neighbor (1:4) propensity score matching 2013 2019 data from National Free Preconception Checkup Project (NFPCP), a national free health service for childbearing-aged...
<h3>Importance</h3> Maternal thyrotropin levels during gestation have a profound effect on pregnancy outcomes; however, few studies to date evaluated the importance of preconception levels. <h3>Objective</h3> To investigate associations between and outcomes. <h3>Design, Setting, Participants</h3> This population-based cohort study enrolled Chinese women aged 20 49 years from National Free Prepregnancy Checkups Project in China. Participants conceived within 6 months after examination...
<h3>Importance</h3> Abundant evidence suggests thyroid dysfunction is associated with adverse pregnancy outcomes. However, associations of preconception thyrotropin levels outside reference range reproductive health outcomes are not well characterized. <h3>Objective</h3> To evaluate the time to (TTP) and risk spontaneous abortion (SA). <h3>Design, Setting, Participants</h3> This population-based cohort study used data from Chinese National Free Prepregnancy Checkups Project. Female...
Inconsistent results were found in the association between serum alanine aminotransferase (ALT) and hypertension among population-based studies. This study evaluated ALT Chinese reproductive-age population by utilizing registration data from National Free Pre-pregnancy Checkups Project 2016-2017. The 21,103,790 registered participants eligible for analysis, including women who 20-49 years old men 20-59 with available blood pressure (BP). Logistic regression was conducted to estimate odds...
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Evidence of couples' BMI and its influence on birth weight is limited contradictory. Therefore, this study aims to assess the association between couple's preconception risk small for gestational age (SGA)/large (LGA) infant, among over 4·7 million couples in a retrospective cohort based National Free Pre-pregnancy Checkups Project 1 December 2013 30 November 2016 China. Among live births, 256 718 (5·44 %) SGA events 506 495 (10·73 LGA were documented, respectively. After adjusting...
Approximately a quarter of the world population had been infected with Mycobacterium tuberculosis , and about 5 to 10% these individuals might develop active disease in their lifetimes. As critical component “end TB strategies,” preventive treatment was shown protect 60 90% high-risk LTBIs from developing disease.
The risk of emerging infectious diseases (EID) is increasing globally. More than 60% EIDs worldwide are caused by animal-borne pathogens. This study aimed to characterize the virome, analyze phylogenetic evolution, and determine diversity rodent-borne viruses in Hainan Province, China. We collected 682 anal throat samples from rodents, combined them into 28 pools according their species location, processed for next-generation sequencing bioinformatics analysis. diverse viral contigs closely...
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Background Diabetes mellitus (DM) patients with latent tuberculosis infection (LTBI) have an increased risk of developing active (TB) due to impaired immunity. The performance currently available immune response-based assays for identification TB had been rarely evaluated in type 2 DM (T2DM) China. Methods A prospective study was conducted investigate the status LTBI confirmed T2DM. At baseline survey, prevalence tested using interferon-gamma release assay (IGRA), tuberculin skin test (TST)...
Abstract Background The evidence on the association of fine particulate matter with an aerodynamic diameter 2.5 μm or less (PM ) pulmonary tuberculosis (PTB) retreatment is limited. There are no data whether greenness exposure protects air pollution–related PTB in patients prior PTB. Objective In a population-based retrospective study, we aimed to investigate influence PM and residential risk retreatment. Methods A total 26,482 incident PTB, registered mandatory web-based reporting system...
Background Recurrence posed an important challenge to pulmonary tuberculosis (PTB) control in China. The prospective study aimed identify potential risk factors and explore the value of QuantiFERON-TB Gold Plus (QFT-Plus) identifying at-risk individuals with treated prior PTB history.
The association between serum alanine aminotransferase (ALT) concentrations and the incidence of hypertension remains unclear. To explore ALT levels risk incident based on Kailuan cohort study. People who had participated in health check-ups 2006-2007 without hypertension, cardiovascular, or liver diseases were enrolled received follow-ups every two years until December 2017. Hypertension was defined as systolic blood pressure/diastolic pressure ≥140/90 mmHg using anti-hypertensive...
Abstract Single-cell RNA sequencing (scRNA-seq) is a widely used method for classifying cell types and states revealing disease mechanisms. However, most contemporary scRNA-seq platforms fail to explore the multi-landscape of RNA. Here, we designed microfluidic chip combined oligo-dT primers Random Bridging Co-labeling (RBCL) develop an innovative Chigene technology that can identify gene expression, mutations, splicing landscapes at single-cell level. The platform demonstrated exceptional...
To assess the impact of preconception alcohol consumption on risk miscarriage incidence, and further evaluate association between maternal periconception drinking abstinence miscarriage.We performed a population-based, retrospective cohort study in China 1 January 2013 31 December 2016. Alcohol intake potential confounding factors were reported standard questionnaires. Participants who became pregnant recontacted for pregnancy outcome information within year. A total 4 531 680 women with...