A5101551925- Viral gastroenteritis research and epidemiology
- Respiratory viral infections research
- Viral Infections and Immunology Research
- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- Animal Virus Infections Studies
- Air Quality and Health Impacts
- Vibrio bacteria research studies
- Tuberculosis Research and Epidemiology
- Climate Change and Health Impacts
- Aquaculture disease management and microbiota
- Salmonella and Campylobacter epidemiology
- Liver Disease Diagnosis and Treatment
- Cytomegalovirus and herpesvirus research
- Infection Control and Ventilation
- Mycobacterium research and diagnosis
- COVID-19 Clinical Research Studies
- Advanced oxidation water treatment
- Virus-based gene therapy research
- Urban Heat Island Mitigation
- Alcohol Consumption and Health Effects
- China's Socioeconomic Reforms and Governance
- Iron oxide chemistry and applications
- Biosensors and Analytical Detection
- interferon and immune responses
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2025
Beijing Center for Disease Prevention and Control
2019-2024
National Marine Environmental Monitoring Center
2024
Nanjing Medical University
2024
China National Environmental Monitoring Center
2024
Shunyi Hospital of Beijing Traditional Chinese Medicine Hospital
2023
Beijing Hospital
2023
China Medical University
2022
Capital Medical University
2018-2022
Guangdong University of Foreign Studies
2022
Abstract We develop a statistical model using extreme value theory to estimate the 2000–2050 changes in ozone episodes across United States. relationships between daily maximum temperature ( T max ) and 8 h average (MDA8) May–September over 2003–2012 Point Process (PP) model. At ~20% of sites, marked decrease ozone‐temperature slope occurs at high temperatures, defined as suppression. The PP sometimes fails capture ozone‐ relationships, so we refit logistic regression generalized Pareto...
Evidence showed that air pollution was associated with an increased risk of tuberculosis (TB). This study aimed to the impact long-term exposure ambient particulate matter aerodynamic diameter less than 2.5 μm (PM2.5) on acquisition LTBI and subsequent active disease development among rural older adults from a multicentre cohort, which have not yet been investigated date. A total 4790 were included in population-based, multicenter, prospective cohort (LATENTTB-NSTM) 2013 2018. The level...
Typhoid fever remains a major public health problem in developing countries. Waterborne typhoid affects an estimated 27 million people worldwide each year. Decades of indiscriminate antibiotic usage has driven the emergence and spread multidrug-resistant (MDR) even extensively drug-resistant (XDR) Salmonella Typhi (S. Typhi) strains.By combining epidemiological investigations, bacterial isolation from patients household water, whole genome sequencing drug resistance analysis, we identified...
<title>Abstract</title> <bold>Background</bold> The adverse effects of long-term exposure to particulate matter (PM<sub>2.5</sub>) have been found be closely associated with mortality. However, the relevant research on different levels in rural areas is insufficient China.<bold>Methods</bold> Based a multicenter population-based prospective study, adult residents (≥ 15 years old) from three study sites PM<sub>2.5</sub> were tracked for death events between 2013 and 2023. estimated values...
From 2020 to 2022, a pulmonary tuberculosis (PTB) active case finding project based on chest X-ray (CXR) examination was conducted targeting individuals aged ≥ 65 years old in Jiangshan County, Quzhou City. The current study used computer-aided detection (CAD) software (JF CXR-1 v2) retrospectively analyze the CXR images and estimate its potential capacity for identifying PTB cases. information of notified microbiologically confirmed among participants were exported from Tuberculosis...
To analyze the epidemiological characteristics of group A rotavirus (RVA) diarrhea in Beijing between 2019 and 2022 evaluate effectiveness RV5 vaccine. Stool specimens were collected from patients with acute diarrhea, RVA was detected genotyped. The whole genome sequenced by fragment amplification Sanger sequencing. Phylogenetic trees constructed using Bayesian maximum likelihood methods. Descriptive methods used to diarrhea. Test-negative design vaccine (VE) RV5. Compared 2011-2018,...
We conducted a surveillance among acute respiratory tract infection (ARTI) cases to define the epidemiology, clinical characteristics and genetic variations of enterovirus D68 (EV-D68) in Beijing, China from 2015 2017. Nasopharyngeal swabs sputum were collected 30 sentinel hospitals Beijing subjected EV EV-D68 detection by real-time PCR. The VP1 gene region complete genome sequences positive analyzed. Of 21816 ARTI cases, 619 (2.84%) 42 positive. rates 0 (0/6644) 2015, 0.53% (40/7522) 2016...
An abstract is not available for this content so a preview has been provided. As you have access to content, full PDF via the 'Save PDF' action button.
Abstract We compared the sensitivity and specificity of four commercial coronavirus disease (COVID‐19) diagnostic kits using real‐time reverse transcription–polymerase chain reaction (RT‐PCR). Kits I‐IV approved by State Drug Administration China were selected, detection targets ORF1ab gene N gene. Specificity was evaluated detecting other respiratory viruses. The batch effect each kit testing 10‐fold dilutions RNA. Clinical application verified nasopharyngeal swab sputum specimens from...
Abstract New norovirus (NoV) variants emerge often leading to increased acute gastroenteritis outbreaks and outpatient visits. However, these increases are rarely quantified. Between September 2011 August 2018, we included a total of 133 131 diarrhoea cases in 11 enteric disease clinics which were open all year round Beijing. Over the same period, etiology surveillance for was conducted, 13 139 specimens collected tested, 16.84% (2213/13 139) NoV‐positive. The partial VP1 genes successfully...
Abstract Background The evidence on the association of fine particulate matter with an aerodynamic diameter 2.5 μm or less (PM ) pulmonary tuberculosis (PTB) retreatment is limited. There are no data whether greenness exposure protects air pollution–related PTB in patients prior PTB. Objective In a population-based retrospective study, we aimed to investigate influence PM and residential risk retreatment. Methods A total 26,482 incident PTB, registered mandatory web-based reporting system...
Uric acid as a prominent causal factor in the pathogenesis of hypertension is well recognized. Nevertheless, influence uric on transition from prehypertension to within Chinese population remains understudied.
To investigate the seroepidemiological features of enterovirus D68 (EV-D68) in healthy population from 2012 to 2017 Beijing, China. A retrospective cross-sectional investigation was conducted using serum specimens collected individuals Beijing 2017. These samples were tested for neutralization antibodies (NtAbs) against EV-D68. The sera six EV-D68 infected patients acute or convalescent phase used determine protection level NtAbs geometric means titers (GMT) and 92.82 242.91, respectively;...
Norovirus (NoV) is the leading pathogen responsible for global acute gastroenteritis (AGE) outbreaks and sporadic cases. NoV evolves through gene mutation recombination, to emergence of new strains capable causing epidemics. This study aimed learn epidemiological characteristics 39 GI.6[P11] in Beijing, China, from 2016 2019 analyze genetic diversity phylogenetic process strains. The Bayesian analysis partial VP1 RNA-dependent RNA polymerase (RdRp) genes showed that were clustered into four...
At present, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spread worldwide, which has emerged multiple variants and brought a threat to global public health. To analyze the genomic characteristics variations of SARS-CoV-2 imported into Beijing, we collected tract specimens 112 cases disease 2019 (COVID-19) from January September 2021 in China, including 40 local 72 cases. The whole-genome sequences viruses were sequenced by next-generation sequencing method. Variant markers...
Vibrio parahaemolyticus (V. parahaemolyticus) is a common foodborne pathogen which causes gastroenteritis in humans, especially the O3:K6 pandemic clone still prominent serotype Beijing, China. In this study, we observed novel O10:K4 isolated from clinical diarrhea cases, became most prevalent 2021.73 isolates were collected through sentinel hospitals' surveillance 2021. Serum agglutination testing and antimicrobial susceptibility conducted. Whole genome sequencing was applied to...
Abstract Background Noroviruses are a leading cause of acute gastroenteritis (AGE) worldwide. The geographical characteristics norovirus outbreaks in Beijing and their influencing factors remain unknown. This study aimed to explore the spatial distributions, characteristics, Beijing, China. Methods Epidemiological data specimens were collected through AGE outbreak surveillance system all 16 districts Beijing. Data on distribution, analyzed using descriptive statistics methods. We measured...
The effects of acupuncture on the protein and gene expression oestrogen receptors (ERs) alpha (α) beta (β) in testosterone-induced benign prostatic hyperplasia (BPH) rats remains unclear. In this study, were randomly divided into four groups (n = 10 per group). blank group did not receive any treatment, while model injected intraperitoneally with testosterone propionate for 28 days to establish BPH then sub-divided a control group, an finasteride (positive Dissections performed after...
Background Recurrence posed an important challenge to pulmonary tuberculosis (PTB) control in China. The prospective study aimed identify potential risk factors and explore the value of QuantiFERON-TB Gold Plus (QFT-Plus) identifying at-risk individuals with treated prior PTB history.
Abstract Though pooling samples for SARS-CoV-2 detection has effectively met the need rapid diagnostic and screening tests, many factors can influence sensitivity of a pooled test. In this study, we conducted simulation experiment to evaluate modes specimens aimed at formulating an optimal strategy. We focussed on type swab, their solvent adsorption ability, pool size, volume, different affecting quality preserving RNA by virus solutions. Both quantitative PCR digital were used sampling...