A5053833003- Autism Spectrum Disorder Research
- Viral Infections and Vectors
- Quantum Computing Algorithms and Architecture
- Quantum Information and Cryptography
- Analytical Chemistry and Chromatography
- High-Energy Particle Collisions Research
- Data-Driven Disease Surveillance
- Quantum Mechanics and Applications
- COVID-19 epidemiological studies
- Anomaly Detection Techniques and Applications
- Particle Detector Development and Performance
- Crime Patterns and Interventions
- Electron and X-Ray Spectroscopy Techniques
- Cellular Automata and Applications
- Analytical Methods in Pharmaceuticals
- Antibiotics Pharmacokinetics and Efficacy
- Time Series Analysis and Forecasting
- Automated Road and Building Extraction
- Child Development and Digital Technology
- Topological and Geometric Data Analysis
- Supercapacitor Materials and Fabrication
- Metabolomics and Mass Spectrometry Studies
- DNA and Biological Computing
- Mass Spectrometry Techniques and Applications
- Transportation Safety and Impact Analysis
Hainan Medical University
2022-2025
University of Hong Kong
2023-2025
Brookhaven National Laboratory
2023-2024
Jiujiang University
2024
Nihon University
2024
University of Chicago
2018-2023
University of Illinois Chicago
2021
Chengdu University
2015-2021
Changsha University of Science and Technology
2021
Queensland University of Technology
2017
Phosphatidylinositol 3-kinase (PI 3-K) is implicated in cellular events including glucose transport, glycogen synthesis, and protein synthesis. It activated insulin-stimulated cells by binding of the Src homology 2 (SH2) domains its 85-kDa regulatory subunit to insulin receptor substrate-1 (IRS-1), and, others. We have previously shown that IRS-1-associated PI activity not essential for transport 3T3-L1 adipocytes, alternate pathways exist these cells. now show adenovirus-mediated...
By investigating the action spectra (the relationship between irradiation wavelength and apparent quantum efficiency of reactions under constant irradiance) a number catalyzed by nanoparticles including plasmonic metals, nonplasmonic their alloys at near-ambient temperatures, we found that photon energy threshold exists in each photocatalytic reaction; only photons with sufficient (e.g., higher than level lowest unoccupied molecular orbitals) can initiate reactions. This alignment (and...
Background Scrub typhus, traditionally caused by Orientia tsutsugamushi , is a re-emerging public health concern within the Tsutsugamushi Triangle. Despite growing awareness, prevention strategies remain inadequate on Hainan Island, China, where scrub typhus poses significant threat, especially in field-related environments. Methodology/principal findings Gene flow analysis of tsa56 gene and multilocus sequence typing (MLST) were conducted 156 previously confirmed cases from 2018 to 2021...
Phosphatidylinositol (PI) 3-kinase plays an important role in various insulin-stimulated biological responses including glucose transport, glycogen synthesis, and protein synthesis. However, the molecular link between PI these is still unclear. We have investigated whether targeting of catalytic p110 subunit to cellular membranes sufficient necessary induce dependent signaling responses, characteristic insulin action. overexpressed Myc-tagged, membrane-targeted (p110(CAAX)), wild-type...
We demonstrate universal questionnaire-free screening for autism with significant reduction in false positives.
Reclining is a dangerous posture for occupants in moving vehicles, not only because it can easily induce submarining and cause abdominal injury, but also may increase risk of spinal injury. In this study, the THUMS 50th percentile model used to simulate reclined occupant under 30 km/h frontal impact study effect knee restraint on kinematics. The main findings are as follows. First, if restrained by seatbelt, kinematics collision be very unfavourable. Second, bolster positioned close knees...
Scrub typhus, caused by mite-borne Orientia tsutsugamushi ( O . ), is a major febrile disease in the Asia-Pacific region. The DNA load of blood was previously found to be significantly higher patients with fatal than those non-fatal and correlated duration illness, presence eschar, hepatic enzyme levels. In this prospective observation study, we analyzed association bacterial clinical features, severity, genotype using real-time PCR targeting 56 kDa TSA gene samples 117 surviving scrub...
A sensitive reversed phase-liquid chromatography (RP-LC) method for the simultaneous separation and determination of paclobutrazol myclobutanil enantiomers in water soil was developed. The involved a solid phase extraction from by using C18 Bond-Elut column. LC system consisted cellulose tris-3,5-dimethylphenyl carbamate (CDMPC) chiral stationary (CSP) with mobile methanol–water UV detection. calibration curve each enantiomer linear 0.5–20 μg mL−1. Under suitable conditions, recoveries all...
The risk of emerging infectious diseases (EID) is increasing globally. More than 60% EIDs worldwide are caused by animal-borne pathogens. This study aimed to characterize the virome, analyze phylogenetic evolution, and determine diversity rodent-borne viruses in Hainan Province, China. We collected 682 anal throat samples from rodents, combined them into 28 pools according their species location, processed for next-generation sequencing bioinformatics analysis. diverse viral contigs closely...
Abstract We developed a reliable high-performance liquid chromatographic analysis method using relative molar sensitivity (RMS) technique that does not require an authentic, identical reference analyte material to quantify blood serum carbamazepine, phenytoin, voriconazole, lamotrigine, meropenem, mycophenolic acid, linezolid, vancomycin, and caffeine levels for routine concentration measurements. Carbamazepine were also used as non-analyte materials calculate the RMS of each analyte. The...
Nerium oleander L. (Apocynaceae) is a medium-sized evergreen flowering tree and distributed widely in China. Various parts of N. have been used medicinally are reported to possess wide range biological activities, including cardiotonic, cytotoxic, central nervous system depressant activities. However, there lack in-depth understanding the chemical constituents various oleander.
Abstract Based on our previous report N ‐alkylpyridinium isotope quaternization (NAPIQ) for the analysis of alcoholic and α , β ‐unsaturated ketone compounds, we have further applied NAPIQ method in screening hair lipids drug abusers. Relative isotopic quantification was used comparison fatty alcohols between normal abuse group. The strategy proven to be a high‐throughput metabolic studies different group samples. attached ‐cationic pyridinium significantly improved detection sensitivity...
Abstract Background Orientia tsutsugamushi ( O. ), an obligate intracellular bacterium, is transmitted to humans through infected larval trombiculid mite bites, causing scrub typhus. Mixed genotypes of in canonical conserved genes were reported 8–25% blood samples from patients. Yet, there are few clinical descriptions these mixed -infected Case presentation We report a patient with typhus complicated pulmonary involvement and hepatic dysfunction, who carried the but had single...
High-energy large-scale particle colliders produce data at high speed in the order of 1 terabytes per second nuclear physics and petabytes energy physics. Developing real-time compression algorithms to reduce such throughput fit permanent storage has drawn increasing attention. Specifically, newly constructed sPHENIX experiment Relativistic Heavy Ion Collider (RHIC), a time projection chamber is used as main tracking detector, which records trajectories volume three-dimensional (3D)...
We give the concept, construction and some basic properties of coefficient matrices a multipartite qudit pure state. Then based on them, we obtain necessary sufficient full partial separability criteria for states. These are very practical, operational convenient.
In this paper, by constructing a more entangled quantum system, we shorten the adiabatic search algorithm to constant time. On other hand, show that speed-up of algorithms selecting particular evolution paths or injecting energy into system can be explained as form entanglement enlargement. These findings suggest plays fundamental role for efficiency performance.
Inspired by recent interests of developing machine learning and data mining algorithms on hypergraphs, we investigate in this paper the semi-supervised algorithm propagating ”soft labels” (e.g. probability distributions, class membership scores) over means optimal transportation. Borrowing insights from Wasserstein propagation graphs [Solomon et al. 2014], re-formulate label procedure as a message-passing algorithm, which renders itself naturally to generalization applicable hypergraphs...
Recognizing subtle historical patterns is central to modeling and forecasting problems in time series analysis. Here we introduce develop a new approach quantify deviations the underlying hidden generators of observed data streams, resulting efficiently computable universal metric for series. The proposed sense that can compare contrast streams regardless where how they are generated without any feature engineering step. this paper conceptually distinct from our previous work on smashing,...