A5102008095- DNA Repair Mechanisms
- Pleural and Pulmonary Diseases
- RNA Research and Splicing
- Glioma Diagnosis and Treatment
- COVID-19 diagnosis using AI
- Lung Cancer Diagnosis and Treatment
- Cardiovascular Function and Risk Factors
- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- Advanced MRI Techniques and Applications
- Microtubule and mitosis dynamics
- Mechanical Behavior of Composites
- Medical Imaging Techniques and Applications
- Cardiac Imaging and Diagnostics
- Bone and Joint Diseases
- Birth, Development, and Health
- Bone health and treatments
- Cancer therapeutics and mechanisms
- Ocular Oncology and Treatments
- Genomics and Chromatin Dynamics
- Cancer-related Molecular Pathways
- Viral Infections and Vectors
- Mesenchymal stem cell research
- Retinal and Macular Surgery
- Postharvest Quality and Shelf Life Management
Capital Medical University
2022-2024
Chinese Institute for Brain Research
2024
Zhongshan People's Hospital
2024
Harbin Medical University
2020-2024
University of North Carolina at Chapel Hill
2021-2024
Hebei Medical University
2023-2024
Shandong University
2024
Sichuan University
2023
West China Hospital of Sichuan University
2023
Institute of Applied Ecology
2023
Abstract Almost all Glioblastoma (GBM) are either intrinsically resistant to the chemotherapeutical drug temozolomide (TMZ) or acquire therapy-induced mutations that cause chemoresistance and recurrence. The genome maintenance mechanisms responsible for GBM hypermutation unknown. We show E3 ubiquitin ligase RAD18 (a proximal regulator of TLS) is activated in a Mismatch repair (MMR)-dependent manner TMZ-treated cells, promoting post-replicative gap-filling survival. An unbiased CRISPR screen...
Cancer cells employ alternative splicing (AS) to acquire isoforms favouring their survival. However, the causes of aberrant AS in breast cancer are poorly understood. In this study, METABRIC (Molecular Taxonomy Breast International Consortium) data were analysed with univariate feature selection. Of 122 spliceosome components, U2SURP, PUF60, DDX41, HNRNPAB, EIF4A3, and PPIL3 significantly associated The top 4 four genes, chosen for further analyses. Their expression was molecular subtype,...
pill, a Traditional Chinese Medicine (TCM) prescription and representative of
Through bioassay-guided fractionation of the extracts from aerial parts Chinese herb Hypericum japonicum Thunb. Murray, Isojacareubin (ISJ) was characterized as a potent antibacterial compound against clinical methicillin-resistant Staphylococcus aureus (MRSA). The broth microdilution assay used to determine minimal inhibitory concentrations (MICs) and bactericidal (MBCs) ISJ alone. results showed that its MICs/MBCs ranged 4/16 16/64 μg/mL, with required inhibit or kill 50% strains...
The coronavirus disease 2019 (COVID-19) pandemic and related public health intervention measures have been reported to resulted in the reduction of infections caused by influenza viruses other common respiratory viruses. However, influence may be varied areas that different ecological, economic, social conditions. This study investigated changing epidemiology 8 pathogens, including Influenza A (IFVA), B (IFVB), Respiratory syncytial virus (HRSV), rhinovirus (RV), Human metapneumovirus...
The thioflavin T derivative, 11C-Pittsburgh-B (PIB), is used for Alzheimer's disease imaging because it specifically binds to β-amyloid protein deposits in the brain. aim of this study was estimate diagnostic value combined 11C-PIB positron emission tomography/magnetic resonance (PET/MR) cardiac amyloidosis (CA).We enrolled 23 heart failure patients with suspected CA based on echocardiographic and electrocardiograph findings. All underwent PET/MR non-cardiac biopsy within one week. We also...
BACKGROUND: Alternative splicing is a mechanism to produce different proteins with diverse functions from one gene. Many factors play an important role in cancer progression. PRPF8 core protein component of the spliceosome complex, U4/U6-U5 tri-snRNP. OBJECTIVE: However, involved mRNA alternative are rarely included prognosis. METHODS: We found that was expressed all examined types. Further analyses expression significantly between breast and paracancerous tissues. RESULTS: Survival showed...
Abstract Background Whether cognitive ageing trajectory is related to common functional deficits independent of initial function remains inconclusive. We aimed explore the adverse health effect and potential predictive factors distinct trajectories among Chinese older adults. Methods Three thousand five hundred eighty-one community-dwelling adults who completed three consecutive examinations with Mini-Mental State Examination (MMSE) over 5 years were without impairment at enrollment...
It is important to control CRISPR/Cas9 when sufficient editing obtained. In the current study, rational engineering of guide RNAs (gRNAs) performed develop small-molecule-responsive CRISPR/Cas9. For our purpose, sequence gRNAs are modified introduce ligand binding sites based on design ligand-RNA pairs. Using short target sequences, we demonstrate that engineered RNA provides an excellent scaffold for small molecule ligands. Although 'stem-loop 1' variants gRNA induced variable cleavage...
HIV viral load (VL) is an important indicator to monitor treatment response in antiretroviral therapy (ART). Patients on ART may experience blips, with low-level elevations of VL between 50 and 999 copies/mL known as viraemia (LLV), but not reaching the threshold for virological failure (≥1,000 copies/mL) defined by WHO guidelines. The objective was investigate long-term impact LLV failure.We analyzed adults who were naïve at baseline. having 51-999 least once. subjects grouped into three...
Scrub typhus, caused by mite-borne Orientia tsutsugamushi ( O . ), is a major febrile disease in the Asia-Pacific region. The DNA load of blood was previously found to be significantly higher patients with fatal than those non-fatal and correlated duration illness, presence eschar, hepatic enzyme levels. In this prospective observation study, we analyzed association bacterial clinical features, severity, genotype using real-time PCR targeting 56 kDa TSA gene samples 117 surviving scrub...
Viral encephalitis continues to be a significant public health concern. In our previous study, we discovered lower expression of antiviral factors, such as IFN-β, STING and IFI16, in the brain tissues patients with Rasmussen's (RE), rare chronic neurological disorder often occurred children, characterized by unihemispheric atrophy. Furthermore, higher cumulative viral score human herpes viruses (HHVs) was also found have significantly positively correlated atrophy RE. Type I IFNs (IFN-I)...
The red flour beetle, Tribolium castaneum (Herbst) (Coleoptera: Tenebrionidae), is a major storage pest that could lead to wide range of damage. Its secretions have significant impact on the quality stored grain and food, leading serious food safety problems such as spoilage carcinogenesis. This study investigates new detection techniques for pests improve insect in China. primary volatile organic chemicals (VOCs) these are identified using headspace solid-phase microextraction (HS-SPME)...
Purpose. To assess the efficacy of neoadjuvant chemotherapy plus limb-sparing surgery for osteosarcoma and its impact on long-term quality life. Methods. Between August 2016 December 2018, 90 patients with treated in Nanchong Central Hospital were recruited divided at a ratio 1 : to receive (control group) or (study by random number table methods. The clinical endpoints Results. Limb-sparing was associated significantly higher versus alone. resulted Enneking score good function rating...
Objectives:We sought to evaluate the feasibility and accuracy of free-breathing three-dimensional (3D) phasesensitive inversion-recovery (PSIR) Turbo FLASH sequence for noninvasive assessment left ventricular myocardial scar in swine models. Materials Methods:Nine Chinese minipigs with experimentally induced acute infarction were studied.At 1 week study endpoint 4 weeks after surgery, 3D 2D contrasted cardiac magnetic resonance (CMR) imaging performed randomly by using a 1.5T clinical MR...
We aimed to assess the effects of serratus anterior plane block (SAPB) and thoracic paravertebral nerve (TPVB) on analgesia, immune function serum tumor markers in patients after thoracoscopic radical resection lung cancer. A total 132 enrolled from February 2019 November 2020 were prospectively selected randomly divided into 3 groups (n=44). Control group received general anesthesia. After induction anesthesia, TPVB or SAPB was given SAPB. Their clinical data, operation conditions, Visual...
Breast cancer (BC) is the most frequently diagnosed malignancies in females, and its incidence has increased dramatically recently. Clinical studies have shown that BC patients are developing double primary cancers more than by chance, prognosis changed greatly. Previous articles rarely mentioned metachronous survivors. Thus, further analysis of clinical characteristics survival differences may provide valuable information survivors.In this study, we retrospectively analyzed 639 cases...
ABSTRACT Almost all Glioblastoma (GBM) are either intrinsically resistant to the chemotherapeutical drug temozolomide (TMZ) or acquire therapy-induced mutations that cause chemoresistance and recurrence. The genome maintenance mechanisms responsible for GBM hypermutation unknown. We show E3 ubiquitin ligase RAD18 (a proximal regulator of TLS) is activated in a Mismatch repair (MMR)-dependent manner TMZ-treated cells, promoting post-replicative gap-filling survival. An unbiased CRISPR screen...