A5034764240- Microbial Natural Products and Biosynthesis
- Carbohydrate Chemistry and Synthesis
- Antibiotic Resistance in Bacteria
- Biochemical and Structural Characterization
- X-ray Diffraction in Crystallography
- Antifungal resistance and susceptibility
- Crystallization and Solubility Studies
- Microbial Metabolism and Applications
- GABA and Rice Research
- Diabetes Treatment and Management
- Peptidase Inhibition and Analysis
- Catalytic C–H Functionalization Methods
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Metabolism, Diabetes, and Cancer
- RNA and protein synthesis mechanisms
- Pneumocystis jirovecii pneumonia detection and treatment
- Food Quality and Safety Studies
- Genomics and Phylogenetic Studies
- Organophosphorus compounds synthesis
- DNA and Nucleic Acid Chemistry
- Pharmacological Effects of Natural Compounds
- Synthesis of Indole Derivatives
- Ion Transport and Channel Regulation
- Tuberculosis Research and Epidemiology
- Synthetic Organic Chemistry Methods
Beijing National Laboratory for Molecular Sciences
2017-2023
Peking University
2017-2023
Center for Life Sciences
2017-2023
Laboratoire des Biomolécules
2019
Tuberculosis (TB) is a life-threatening disease resulting in an estimated 10 million new infections and 1.8 deaths annually, primarily underdeveloped countries. The economic burden of TB has been as approximately 12 billion USD annually direct indirect costs. Additionally, multi-drug-resistant (MDR) extreme-drug-resistant (XTR) strains about 250 000 are now widespread, increasing pressure on the identification anti-TB agents that operate by novel mechanism action. Chrysomycin A rare C-aryl...
Sodium glucose co-transporters (SGLT) harness the electrochemical gradient of sodium to drive uphill transport across plasma membrane. Human SGLT1 (hSGLT1) plays a key role in sugar uptake from food and its inhibitors show promise treatment several diseases. However, inhibition mechanism for hSGLT1 remains elusive. Here, we present cryo-EM structure hSGLT1-MAP17 hetero-dimeric complex presence high-affinity inhibitor LX2761. LX2761 locks transporter an outward-open conformation by wedging...
C-Glycosides are critical motifs embedded in many bioactive natural products. The inert C-glycosides privileged structures for developing therapeutic agents owing to their high chemical and metabolic stability. Despite the comprehensive strategies tactics established past few decades, highly efficient C-glycoside syntheses via C-C coupling with excellent regio-, chemo-, stereoselectivity still needed. Here, we report Pd-catalyzed glycosylation of C-H bonds promoted by weak coordination...
Staphylopine was discovered and functionally evaluated as a novel type of metallophore that Staphylococcus aureus employs to acquire multiple divalent transition metals. Aspergillomarasmine A (AMA), with similar structure staphylopine, recently identified an inhibitor metallo-β-lactamases NDM-1 VIM-2. Herein, we report unified approach using Mitsunobu reaction key step accomplish the concise efficient total syntheses staphylopine AMA. We also elucidate broad-spectrum metal chelation...
The first total synthesis and isolation of pseudopaline was reported, which allows determination confirmation the absolute configuration natural product.
Abstract A new type of a cage-phosphate with resemblance to the adamantane structure, namely myo-inositol 1,3,5-O-phosphate was synthesized by debenzylation 2,4,6-O-trisbenzyl myo-inositol-1,3,5-O-phosphate, which obtained either direct phosphorylation 2,4,6-O-tribenzyl phosphorus oxychloride or treatment triamide followed subsequent oxidation. The structure confirmed 2D NMR spectrum.