A5071269899- Antibiotic Resistance in Bacteria
- Tuberculosis Research and Epidemiology
- Metabolism, Diabetes, and Cancer
- Mesenchymal stem cell research
- Bone Metabolism and Diseases
- Pneumocystis jirovecii pneumonia detection and treatment
- Peroxisome Proliferator-Activated Receptors
- Computational Drug Discovery Methods
- MicroRNA in disease regulation
- Bone health and treatments
- Growth Hormone and Insulin-like Growth Factors
- Diabetic Foot Ulcer Assessment and Management
- Peptidase Inhibition and Analysis
- Angiogenesis and VEGF in Cancer
- Nuclear Receptors and Signaling
- Hippo pathway signaling and YAP/TAZ
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Alkaline Phosphatase Research Studies
- Connective Tissue Growth Factor Research
- Pancreatic function and diabetes
- Synthesis and biological activity
- Immune responses and vaccinations
- Biomarkers in Disease Mechanisms
- Telomeres, Telomerase, and Senescence
- Wound Healing and Treatments
Southern University of Science and Technology
2016-2025
University of Hong Kong
2018-2020
Drug-resistant superbugs pose a huge threat to human health. Infections by Enterobacteriaceae producing metallo-β-lactamases (MBLs), e.g., New Delhi metallo-β-lactamase 1 (NDM-1) are very difficult treat. Development of effective MBL inhibitors revive the efficacy existing antibiotics is highly desirable. However, such not clinically available till now. Here we show that an anti-Helicobacter pylori drug, colloidal bismuth subcitrate (CBS), and related Bi(III) compounds irreversibly inhibit...
A novel sprayable adhesive is established (ZnMet-PF127) by the combination of a thermosensitive hydrogel (Pluronic F127, PF127) and coordination complex zinc metformin (ZnMet). Here we demonstrate that ZnMet-PF127 potently promotes healing traumatic skin defect burn injury promoting cell proliferation, angiogenesis, collagen formation. Furthermore, find ZnMet could inhibit reactive oxygen species (ROS) production through activation autophagy, thereby protecting from oxidative stress induced...
Abstract The newly identified mobile colistin resistant gene ( mcr-1 ) rapidly spread among different bacterial strains and confers resistance to its host, which has become a global concern. Based on sequence alignment, MCR-1 should be phosphoethanolamine transferase, members of the YhjW/YjdB/YijP superfamily catalyze addition lipid A, needs validated experimentally. Here we report first high-resolution crystal structure C-terminal catalytic domain (MCR-1C) in native state. active pocket...
β-Lactam antibiotics are the mainstay for treatment of bacterial infections. However, elevated resistance to these mediated by metallo-β-lactamases (MBLs) has become a global concern.
The bone marrow microenvironment contains heterogeneous stromal cells, which are critical for remodeling and provide essential supportive roles hematopoietic functions. Although the diversity of PDGFRα+β+ mesenchymal stromal/stem cells (MSCs) get consensus, osteo-lineage (OLCs) that constitute developmental trajectory osteoblasts largely remain unclear. Here, we construct a comprehensive atlas cell via performing integrative single analyses 77 samples from 14 datasets. Besides previously...
Osteoporosis (OP) is a systemic skeletal disease that primarily affects the elderly population, which greatly increases risk of fractures. Here we report Kindlin-2 expression in adipose tissue during aging and high-fat diet fed accompanied by decreased bone mass. specific deletion (K2KO) controlled Adipoq-Cre mice or tissue-targeting AAV (AAV-Rec2-CasRx-sgK2) significantly Mechanistically, promotes peroxisome proliferator-activated receptor gamma (PPARγ) activation downstream fatty acid...
Abstract Insufficient pancreatic β-cell mass and reduced insulin expression are key events in the pathogenesis of diabetes mellitus (DM). Here we demonstrate high Talin-1 β-cells that deficiency reduces proliferation, which leads to expression, thus causing glucose intolerance without affecting peripheral sensitivity mice. High-fat diet fed exerbates these phenotypes. Mechanistically, interacts with E3 ligase smad ubiquitination regulatory factor 1 (Smurf1), prohibits signal transducer...
The insulin-like growth factors (IGFs), IGF-I and IGF-II, are essential for regulating cell growth, differentiation metastasis of a broad range malignancies.The IGF-I/II actions mediated through the IGF receptor type 1 (IGF-1R) insulin (IR), which overexpressed in multiple types tumors.Here, we have firstly identified human engineered antibody domain (eAd) from phage-displayed VH library.The eAd suppressed signal transduction IGF-1R by exogenous or IGF-II breast cancer lines neutralizing...
Mycoplasma hyopneumoniae (M. hyopneumoniae) is the causative agent of pandemic pneumonia among pigs, namely, swine enzootic pneumonia. Although M. was first identified in 1965, little known regarding its metabolic pathways, which might play a pivotal role during disease pathogenesis. Lipoate an essential cofactor for enzymes important central metabolism. However, lipoate metabolism pathway definitely unclear. Here, we novel gene, lpl, encoding protein ligase genome (Mhp-Lpl). This gene...
Alveolar bone loss is a main manifestation of periodontitis. Human periodontal ligament stem cells (PDLSCs) are considered as optimal seed for alveolar regeneration due to its mesenchymal cell like properties. Osteogenic potential the premise PDLSCs repair loss. However, mechanism regulating osteogenic differentiation remain elusive. In this study, we identified Neuron-derived orphan receptor 1 (NOR1), was particularly expressed in PDL tissue vivo and gradually increased during vitro....