The superhydrophobic Zn-based coating with hierarchical structure has good prospects in metal anticorrosion. However, the practical application of is still limited by poor mechanical stability micro/nano structure. Herein, a robust Zn/ZnO pine needle-like and superior corrosion resistance was design constructed. micro-scale polyhedral Zn fabricated on steel followed deposition radially aligned ZnO nanorods, forming novel structure, which finally modified stearic acid. Notably, structured...

The involvement of neurons in the peripheral nervous system is crucial for bone regeneration. Mimicking extracellular matrix cues provides a more direct and effective strategy to regulate neuronal activity enhance However, simultaneous coupling intrinsic mechanical-electrical microenvironment implants innervated regeneration has been largely neglected. Inspired by mechanical bioelectric properties microenvironment, this study constructed (M-E) model based on barium titanate piezoelectric...

ABSTRACT Mammary tumours are the most common type of neoplasm in female dogs, with nearly half being malignant. Oncolytic Newcastle disease virus (NDV) therapy has emerged as a novel cancer treatment option; however, its precise oncolytic mechanism canine mammary (CMT) remain unclear. Ultrastructural analysis NDV‐infected CMT‐U27 cells locally damaged cell membranes and swollen ruptured mitochondria revealed occurrence pyroptosis. Transcriptome sequencing further identified significant...

The substitution of metal sites in Mg2TiO4 substrate leads to charge imbalance that will be closely related a variety changes including lattice structure, cell distortion, and photophysical properties. Herein, the co-substitution strategy [Ga3+–Ga3+] for [Mg2+–Ti4+] Sn4+ Ti4+ achieves first time novel Mg3Ga2SnO8 (MGS):xMn4+ (x = 0–3%) phosphors with efficient red emissions. In terms X-ray powder diffraction (XRD) Rietveld refinement analysis, MGS:Mn4+ possesses structure isotypic cubic space...

Low-temperature plasma, an engineered technology to generate various reactive species, is actively studied in cancer treatment recent years, yet mainly by using a traditional 2D cell culture system. In this study, we explored the effect of plasma-activated medium (PAM) on lung cells vitro and vivo 3D model. The results showed that PAM markedly inhibited spheroid formation downregulated stemness-related gene expression. We found oxygen species (ROS) penetrated throughout whole spheroids...

Abstract Background Increasing evidence indicates that radiotherapy (RT) has synergistic inhibitory efficiency with immunotherapy agents in multiple cancers and enhances abscopal effects by regulating the innate immune response, which was further investigated this study. Neutrophils are recruited radiated tumors. Therefore, neutrophil membrane-coated nanoparticles potentially deliver R837 (Toll-like receptor 7 agonist) to Methods A novel nanoparticle R837@PLGA@Neu prepared initially...

Ovarian cancer (OC) is one of the most common malignancies female reproductive system. The miRNA miR-582-3p associated with a variety tumors, and aim this study was to investigate role mechanisms specifically in ovarian carcinogenesis progression. Low expression noted OC tissue cell lines, lower correlated overall survival patients. Knockdown promoted proliferation migration cells, while overexpression inhibited them. TUG1, long non-coding RNA, found bind miR-582-3p, inhibition lncRNA TUG1...

A novel CBP with good optical transmittance, hydrophobicity, mechanical toughness, heat sealability, ionic conductivity, and recyclability is reported.

Family with sequence similarity 3, member C (FAM3C) has been identified as a novel regulator in epithelial-mesenchymal transition (EMT) and metastatic progression. However, the role of FAM3C esophageal squamous cell carcinoma (ESCC) remains unexplored. The purpose present study is to illustrate predicting outcomes patients ESCC. expression was measured ESCC tissues matched adjacent nontumorous by quantitative real-time RT-PCR Western blot analysis. relationship between prognosis further...

Biodegradable transparent wood was fabricated by introducing epoxy resin E51 modified with the silane coupling agent (KH550) into bleached poplar veneer. The light transmittance of modulated KH550 content. able to change compatibility and substrate, thereby affecting performance wood. In this study, effect on properties its mechanism were investigated. transmittance, tensile strength, elongation at break showed an increasing then decreasing trend increased dosage. When mass ratio 1:20, made...

Abstract Spontaneous canine mammary carcinomas (CMCs) have been widely considered a good research model for human breast cancers, which brings much attention to CMCs. In recent years, the oncolytic effect of Newcastle disease virus (NDV) on cancer cells has studied, but its CMCs is still unclear. This study aims investigate NDV LaSota strain carcinoma cell line (CMT‐U27) in vivo and vitro. The vitro cytotoxicity immunocytochemistry experiments showed that selectively replicated CMT‐U27...

Single-phase phosphors with tunable emission colors are crucial to develop high-performance white light-emitting diodes since they valuable improve the energy efficiency, color rendering index, and correlated temperature. Most of studies have been conducted control spectral shifts via a polyhedral distortion or chemical unit cosubstitution strategy. The combination host optimization dopant activator design in single-phase phosphor system is very rare. Herein, partial substitution strategy...

The full name of the FTO gene is fat mass and obesity-associated gene. In recent years, it has also been found that involved in m6A demethylation regulates progression multiple cancers, including gastric cancer. cancer stem cell theory argues cells are key factors metastasis, inhibiting expression stemness genes a good method to inhibit metastasis Currently, role regulating still unclear. By analyzing public databases, was discovered increased cancer, high associated with poor prognosis...

SOX8 plays an important role in several physiological processes. Its expression is negatively associated with overall survival patients colorectal carcinoma (CRC), suggesting a potential prognostic factor for this disease. However, the of CRC remains largely unknown. In study, our data showed that was upregulated cell lines and tumor tissues. Stable knockdown dramatically reduced proliferation, migration, invasion. Furthermore, decreased phospho-GSK3β level suppressed Frizzled-6 (FZD6)...

Background: Polycystic ovary syndrome (PCOS) stands as one of the most prevalent endocrine disorders affecting women reproductive age. Despite being recognized for decades, numerous unresolved issues persist regarding its impact on medicine. Metformin, a widely utilized drug in clinical practice PCOS management, has attracted researchers' attention due to pharmacological mechanism and novel combination methods. Methods: This study employs bibliometric analysis comprehensively examine...

To screen for specific transcription factors (TFs) that induce expression of the HMGB1 promoter in response to stimulation by Ang-II. A overexpressing vector and small interfering (si)RNA were constructed used transfect three HCC cell lines scratched monolayer wound healing Transwell assays. Chromatin immunoprecipitation (ChIP) assays confirm relationship between a TF promoter. Invasion migration cells after treatment with Ang-II significantly increased compared negative controls (NC);...

Aim: This work aims to develop an injectable nano-drug delivery system overcome tumor multidrug resistance (MDR). Methods: A drug nanoplatform based on PEGylated PLGA with glutathione (GSH) responsivity was constructed for dual of doxorubicin and curcumin (termed DCNP), its MDR reversal efficiency studied in vitro vivo. Results: The DCNPs exhibited a rapid release profile under high GSH concentration could enhance the cellular uptake cytotoxicity cancer cells. Moreover, showed better...