A5056903946- Microbial Natural Products and Biosynthesis
- Genomics and Phylogenetic Studies
- Plant biochemistry and biosynthesis
- RNA and protein synthesis mechanisms
- Synthetic Organic Chemistry Methods
- ECG Monitoring and Analysis
- RNA modifications and cancer
- Wireless Power Transfer Systems
- EEG and Brain-Computer Interfaces
- Microbial Metabolism and Applications
- Analog and Mixed-Signal Circuit Design
- Biochemical and Molecular Research
- Peptidase Inhibition and Analysis
- Chemical Synthesis and Analysis
- Energy Harvesting in Wireless Networks
- Epigenetics and DNA Methylation
- Building Energy and Comfort Optimization
- Medical Research and Treatments
- Peatlands and Wetlands Ecology
- Signaling Pathways in Disease
- Biofuel production and bioconversion
- Influenza Virus Research Studies
- Biochemical and Structural Characterization
- Genetic diversity and population structure
- Microbial Metabolic Engineering and Bioproduction
Huazhong University of Science and Technology
2024
Shanghai Institute of Organic Chemistry
2013-2024
Shandong University of Science and Technology
2024
Joint BioEnergy Institute
2018-2024
Tianjin University of Traditional Chinese Medicine
2024
Chinese Academy of Sciences
2012-2024
University of Chinese Academy of Sciences
2014-2024
Institute of Mountain Hazards and Environment
2022-2024
Hulunbuir University
2019-2022
University of California, Berkeley
2019-2022
QS-21 is a potent vaccine adjuvant and remains the only saponin-based that has been clinically approved for use in humans
Abstract Allosteric transcription factors (aTFs) have proven widely applicable for biotechnology and synthetic biology as ligand-specific biosensors enabling real-time monitoring, selection regulation of cellular metabolism. However, both the biosensor specificity correlation between ligand concentration output signal, also known transfer function, often needs to be optimized before meeting application needs. Here, we present a versatile high-throughput method evolve prokaryotic aTF...
β-Lactam antibiotics are the mainstay for treatment of bacterial infections. However, elevated resistance to these mediated by metallo-β-lactamases (MBLs) has become a global concern.
Abstract Collecting electrophysiological (EP) signals (e.g., electrocardiogram (ECG), electromyogram (EMG)) during exercises is crucial for feedback of cardiac health and muscle injuries. However, since several interferences exist in the skin interface deformation, perspiration, motion artifacts), commercial rigid electrodes/systems have difficulty recording high‐fidelity EP signals. Here, a wireless Nepenthes ‐inspired hydrogel (NIH) hybrid system developed high‐quality signal detection by...
Caerulomycins (CAEs) and collismycins (COLs), which mainly differ in sulfur decoration, are two groups of structurally similar natural products containing a 2,2'-bipyridine (2,2'-BP) core, derivatives have been widely used chemistry. The biosynthetic pathways CAEs COLs remain elusive. In this work, cloning the CAE gene cluster allowed us to mine highly conserved encoding COL biosynthesis Streptomyces strain that was previously unknown as 2,2'-BP producer. vitro vivo investigations into...
This paper proposes a low power and efficient QRS processor for real-time continuous mobile ECG monitoring. The detector contains the wavelet transform (WT), modulus maxima pair identification (MMPI), R position modification (RPM). In order to reduce consumption, we choose Haar function as mother of WT. It is implemented by an optimized FIR filter structure where none multiplier used. MMPI processes coefficients at scale 2 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML"...
Nonribosomal peptide synthetase (NRPS) oxidase (Ox) domains oxidize protein-bound intermediates to install crucial structural motifs in bioactive natural products. The mechanism of this domain remains elusive. Here, by studying indigoidine synthetase, a single-module NRPS involved the biosynthesis and several other bacterial secondary metabolites, we demonstrate that its Ox utilizes an active-site base residue, tyrosine 665, deprotonate l-glutaminyl residue. We further validate generality...
Current influenza antivirals have limitations with regard to their effectiveness and the potential emergence of resistance. Therefore, there is an urgent need for broad-spectrum inhibitors address considerable challenges posed by rapid evolution viruses that limit vaccines lead antiviral drug
ABSTRACT FK506, structurally similar to FK520 and rapamycin, is an α-keto amide bonding-containing, macrolide natural product that exhibits potent immunosuppressive activity moderate antifungal activity. FK506 biosynthesis requires a hybrid polyketide synthase (PKS)-nonribosomal peptide synthetase (NRPS) system construct the skeleton of macrolide. The mechanism for tailoring this furnish remains poorly understood. In study, we report maturation paradigm common FK520, by characterizing two...
Abstract Rehabilitation of patients with lower limb movement disorders is a gradual process, which requires full‐process assessments to guide the implementation rehabilitation plans. However, current methods can only complete assessment in one stage and lack objective quantitative strategies. Here, full‐process, fine‐grained, platform (RAP) supported by on‐skin sensors multi‐task gait transformer (MG‐former) model for developed. The signal quality sensitivity sensor improved synthesis...
Polyketides comprise a large and highly diverse group of natural products produced by polyketide synthases (PKSs), many these compounds display remarkable biological activities. Although PKSs share common mechanism in the assembly polyketides from short carboxylic acid precursors, different types have been classified according to their structures modes action. This review discusses growing bacterial that are structurally type I but act an iterative manner produce aromatic polyketides. We...
Wireless electric vehicle (EV) charger has become increasingly popular because of its improved convenience and safety advantage smaller green-house gas (GHG) emissions. The power control method the wireless transfer (WPT) system great impact on performance charger. In order to simplify electronics converters improve reliability closed-loop control, a novel secondary-side by adding pair bidirectional switches is presented for EV proposed method, which applied double-side LCC compensated...
Abstract Linear nonribosomal peptide synthetases (NRPSs) and polyketide synthases (PKSs) template the modular biosynthesis of numerous peptides, polyketides their hybrids through assembly line chemistry. This chemistry can be complex highly varied, thus challenges our understanding in NRPS PKS-programmed, diverse biosynthetic processes using amino acid carboxylate building blocks. Here, we report that caerulomycin collismycin peptide-polyketide hybrid antibiotics share an involves unusual...
This study presents a tiny pressure sensor which is used to measure the Intracranial Pressure (ICP). The based on piezoresistive effect. simulated and designed by using nonlinear programming optimizing Finite Element Analysis (FEA) tools. Two kinds of sizes are in case childhood adult. sensors fabricated Microelectro Mechanical Systems (MEMS) process. test results yield sensitivities 1.033×10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML"...
Abstract Influenza viruses are among the most common pathogens that threaten health of humans and animals worldwide. Various anti-viral therapeutic agents currently used for treatment prophylaxis influenza virus, but targets these drugs easily mutated result in resistance. Therefore, medications have broad spectrum coverage urgently needed to combat with disease. Since nucleoprotein is regarded as a druggable target due its conserved sequence important functions during virus life cycle,...
Chanodichthys erythropterus is a fierce carnivorous fish widely found in East Asian waters. It not only popular food China, it also representative victim of overfishing. Genetic breeding programs launched to meet market demands urgently require high-quality genomes facilitate genomic selection and genetic research. In this study, we constructed chromosome-level reference genome C. by taking advantage long-read single-molecule sequencing de novo assembly Oxford Nanopore Technology (ONT) Hi-C....
Microbiologically influenced corrosion (MIC) poses a threat to various fields, particularly in piping and cooling water systems. As green inhibitor, polyaspartic acid (PASP) faces challenges achieving the intended inhibition against MIC due biofilm. Therefore, mitigating biofilm might be key improving of PASP. D-Phenylalanine (D-Phe) was selected as an enhancer promote PASP on caused by Desulfovibrio vulgaris its potential role formation this work. The joint application D-Phe reduced rate...