A5100320238- Microbial Natural Products and Biosynthesis
- interferon and immune responses
- Adipose Tissue and Metabolism
- Fungal Biology and Applications
- Ubiquitin and proteasome pathways
- Hemostasis and retained surgical items
- Peptidase Inhibition and Analysis
- Chemical Synthesis and Analysis
- Marine Sponges and Natural Products
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- High Temperature Alloys and Creep
- Antimicrobial Peptides and Activities
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Cytomegalovirus and herpesvirus research
- Immune cells in cancer
- Phytochemical compounds biological activities
- High Altitude and Hypoxia
- Carbohydrate Chemistry and Synthesis
- Systemic Lupus Erythematosus Research
- Chemokine receptors and signaling
- Exercise and Physiological Responses
- Cardiovascular Disease and Adiposity
- Autophagy in Disease and Therapy
- Enzyme Catalysis and Immobilization
University of Chinese Academy of Sciences
2016-2024
Institute of Hydrobiology
2023-2024
Shanghai Institute of Organic Chemistry
2007-2024
Chinese Academy of Sciences
2007-2024
Melbourne Health
2024
Western Health
2024
Shanghai Normal University
2020-2023
Shanghai Zhangjiang Laboratory
2023
Nanjing University
2013-2023
Xi'an Institute of Optics and Precision Mechanics
2023
Rapid water absorption rate has become a bottleneck that limits ultrarapid hemostatic performance of microspheres. Herein, we reported "lotus seedpod surface-like" polysaccharide microsphere (PHM) with "macropits on surface" morphology and "micropores in macropits" structure. Unique macropits surface can promote the because they are advantageous to quickly guide blood into micropores. Special micropores internally connected each other, which endows PHM4 high ratio. During process entering...
To effectively protect the host from viral infection while avoiding excessive immunopathology, innate immune response must be tightly controlled. However, precise regulation of antiviral immunity and underlying mechanisms remain unclear. Here, we find that sirtuin3 (SIRT3) interacts with mitochondrial signaling protein (MAVS) to catalyze MAVS deacetylation at lysine residue 7 (K7), which promotes aggregation, as well TANK-binding kinase I IRF3 phosphorylation, resulting in increased...
Saframycin A (SFM-A), produced by Streptomyces lavendulae NRRL 11002, belongs to the tetrahydroisoquinoline family of antibiotics, and its core is structurally similar ecteinascidin 743, which a highly potent antitumor drug isolated from marine tunicate. In this study, biosynthetic gene cluster for SFM-A was cloned localized 62-kb contiguous DNA region. Sequence analysis revealed 30 genes that constitute cluster, encoding an unusual nonribosomal peptide synthetase (NRPS) system tailoring...
BackgroundIRX3 was recently reported as the effector of FTO variants. We aimed to test IRX3's roles in browning program and evaluate association between genetic variants IRX3 human obesity.MethodsIRX3 expression examined beige adipocytes mouse models, further validated induced adipocytes. The capacity primary preadipocytes assessed with knockdown. Luciferase reporter analysis ChIP assay were applied investigate effects on UCP1 transcriptional activity. Moreover, performed 861 young obese...
Some Shanghai Clinical Center f a role of Niemann-Pick type C1 (NPC1) for obesity traits. However, whether the loss-of-function mutations in NPC1 cause adiposity humans remains unknown. We recruited 25 probands with rare autosomal-recessive C (NP-C) disease and their parents assessment effect heterozygous on adiposity. found that male NPC1+/- carriers had significantly higher BMI than matched control subjects or whole population-based subjects. Consistently, mice increased fat storage while...
Pyridoxal-5′-phosphate (PLP)-dependent proteins constitute one of the largest and most important families enzymes in living organisms. These participate numerous biochemical processes, many which have not been characterized, transform substrates containing an amino group through various reactions that share aldimine as a common intermediate. Herein, we report PLP-dependent CcbF LmbF, are highly related phylogenesis, process cysteine S-conjugated intermediates different ways associate with...
ABSTRACT C-1027, the most potent member of enediyne antitumor antibiotic family, is produced by Streptomyces globisporus C-1027 and consists an apoprotein (encoded cagA gene) a nonpeptidic chromophore. The chromophore could be viewed as being derived biosynthetically from benzoxazolinate, deoxyamino hexose, β-amino acid, core. By adopting strategy for cloning biosynthesis gene cluster mapping putative dNDP-glucose 4,6-dehydratase (NGDH) to , we have localized 75 kb contiguous DNA S. ....
Treatment of systemic lupus erythematosus (SLE), a chronic inflammatory disease, involves the long-term use immunosuppressive agents with significant side effects. New therapeutic approaches are being explored to find better treatment possibilities. In this study, age-matched female MRL/lpr mice were treated orally natural flavonoid astilbin. Astilbin administration started either at week 8 or 12 age though 20. early regimen, astilbin reduced splenomegaly / lymphomegaly, autoantibody...
Thiostrepton (TSR), an archetypal member of the family ribosomally synthesized and post-translationally modified thiopeptide antibiotics, possesses a biologically important quinaldic acid (QA) moiety within side-ring system its characteristic framework. QA is derived from independent l-Trp residue; however, associated transformation process remains poorly understood. We here report that during formation QA, key expansion indole to quinoline relies on activities...
Significance The superfamily of α/β-hydrolase fold proteins consists more than 60,000 different members that share a common Nucleophile-His-Acid catalytic triad at individual active sites. These enzymes function diversely in specific biochemical processes, many which fact remain poorly understood. In this study, we characterized distinct protein, TsrI, exhibits the unprecedented dual activity for endopeptidyl hydrolysis and epoxide ring opening/macrocyclization. TsrI uses same Ser-His-Asp to...
Abstract Oxygen is essential for aerobic organisms, but little known about its role in antiviral immunity. Here, we report that during responses to viral infection, hypoxic conditions repress antiviral-responsive genes independently of HIF signaling. EGLN1 identified as a key mediator the oxygen enhancement innate immune responses. Under sufficient conditions, retains prolyl hydroxylase activity catalyze hydroxylation IRF3 at proline 10. This modification enhances phosphorylation,...
The Src homology 2 domain-containing tyrosine phosphatase (SHP-2) has been reported to have both tumor-promoting and tumor-suppressing roles in tumorigenesis. However, the role of SHP-2 tumor immunity remains unclear. Here we observed progressively lower levels phosphorylated tumor-associated CD4+ T cells during melanoma development a murine model. Similarly, human specimens revealed decrease paralleling cancer development. cell-specific deletion promoted metastasis mice. Furthermore,...