A5028635925- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Optical Wireless Communication Technologies
- Error Correcting Code Techniques
- Cancer, Hypoxia, and Metabolism
- Animal Virus Infections Studies
- RNA modifications and cancer
- Berberine and alkaloids research
- Autophagy in Disease and Therapy
- Cardiovascular Disease and Adiposity
- Lipid metabolism and biosynthesis
- Plant Gene Expression Analysis
- Gastric Cancer Management and Outcomes
- Catalytic Processes in Materials Science
- Nanomaterials for catalytic reactions
- Metastasis and carcinoma case studies
- Advanced Wireless Communication Techniques
- Immune Cell Function and Interaction
- Diet and metabolism studies
- Viral gastroenteritis research and epidemiology
- Telecommunications and Broadcasting Technologies
- Light effects on plants
- Regulation of Appetite and Obesity
- Agriculture, Soil, Plant Science
- Ammonia Synthesis and Nitrogen Reduction
University of Massachusetts Chan Medical School
2017-2024
Nanjing University of Aeronautics and Astronautics
2024
Chinese Academy of Agricultural Sciences
2020-2022
Xinqiao Hospital
2020-2022
Army Medical University
2020-2022
Lanzhou Veterinary Research Institute
2020-2022
Lanzhou University
2022
University of Science and Technology Beijing
2022
Taiyuan University of Technology
2021
Beijing University of Posts and Telecommunications
2016-2018
BackgroundIRX3 was recently reported as the effector of FTO variants. We aimed to test IRX3's roles in browning program and evaluate association between genetic variants IRX3 human obesity.MethodsIRX3 expression examined beige adipocytes mouse models, further validated induced adipocytes. The capacity primary preadipocytes assessed with knockdown. Luciferase reporter analysis ChIP assay were applied investigate effects on UCP1 transcriptional activity. Moreover, performed 861 young obese...
The cross-species infection of coronaviruses has resulted in several major epidemics since 2003. Therefore, it is great importance to explore the host ranges and their features among different hosts. In this study, porcine epidemic diarrhea virus (PEDV), with swine as only natural reservoir, was detected rat fecal samples collected from pig farms. Further animal tests showed PEDV can cause systemic infections neonate mice rats. brain, lung intestine spleen were all targets for rodents...
Transcriptional co-activator Prdm16 controls brown fat development and white browning, but how this thermogenic function is modulated post-translationally poorly understood. Here, we report that Cbx4, a Polycomb group protein, SUMO E3 ligase for Cbx4-mediated sumoylation of required gene expression. Cbx4 expression enriched in induced adipose tissue by acute cold exposure. Sumoylation at lysine 917 blocks its ubiquitination-mediated degradation, thereby augmenting stability function....
Browning of subcutaneous white fat (iWAT) involves several reprograming events, but the underlying mechanisms are incompletely understood. Here we show that transcription factor Hlx is selectively expressed in brown adipose tissue (BAT) and iWAT, translationally upregulated by β3-adrenergic signaling-mediated suppression translational inhibitor 4E-BP1. interacts with co-activated Prdm16 to control BAT-selective gene expression mitochondrial biogenesis. heterozygous knockout mice have defects...
Abstract The signaling mechanisms underlying adipose thermogenesis have not been fully elucidated. Particularly, the involvement of adipokines that are selectively expressed in brown tissue (BAT) and beige adipocytes remains to be investigated. Here we show a previously uncharacterized adipokine (UPF0687 protein / human C20orf27 homolog) named as Adissp (Adipose-secreted protein) is key regulator for white (WAT) glucose homeostasis. expression adipose-specific highly BAT-enriched, its...
Metabolic changes have been suggested to be a hallmark of tumors and are closely associated with tumorigenesis. In previous study, we demonstrated the role lactate dehydrogenase in regulating abnormal glucose metabolism pituitary adenomas (PA). As key organelle oxidative phosphorylation (OXPHOS), mitochondria play vital energy supply for tumor cells. However, few attempts made elucidate mitochondrial metabolic homeostasis PA. Dynamin-related protein 1 (Drp1) is member dynamin superfamily...
Secretory IgA is critical to prevent the invasion of pathogens via mucosa. However, key factors and mechanisms generation in porcine gut are not well understood. In this study, a panel factors, including BAFF, APRIL, CD40L, TGF-β1, IL-6, IL-10, IL-17A, IL-21, were employed stimulate IgM+ B lymphocytes from ileum Peyer's patches. The results showed that IL-21 significantly upregulated production cells facilitated cell proliferation differentiation antibody-secreting cells. addition, three...
Epilepsy is a highly prevalent and drug-refractory neurological disorder characterized by spontaneous recurrent seizures. Estrogen identified to be proconvulsant lowers the seizure threshold of female epilepsy. receptor β (ERβ) has been proposed mediate neuroprotection in epilepsy, although underlying mechanism remains unknown.
In this paper a polar coding scheme for ultraviolet communication (UVC) systems is proposed and experimentally implemented to address the high path loss propagation, which severely deteriorates performance. Firstly, we analyze property of in optical domain by applying particle-wave duality existing model. Considering characteristic UV channel, design code with specific channel correlations, study computational complexity terms length. A new theoretical Bhattacharyya upper-bound general codes...
A new type of conductance sensor has been studied to simultaneously measure both flow rate and water cut oil-water two-phase fluid in production wells. The is obtained by the ratio conductivity mixture that water, cross-correlation measurement, which can determine transit time flowing noise signals passing through upstream downstream sensors sensor. In this article, structure principles measurement are introduced. results dynamic experiment a multiphase loop situ application technology...
Objective Many cancer cells cannot survive without exogenous glutamine (Gln); however, expressing synthetase (GS) do not have this restriction. Previous metabolomics studies indicated that metabolism is altered during pituitary tumorigenesis. However, the main role of Gln in adenoma (PA) pathophysiology remains unknown. The aim study was to evaluate expression GS and human PAs. Methods We used cell proliferation assay flow cytometry assess effect depletion on three different lines primary PA...
The endocrine control of food intake remains incompletely understood, and whether the leptin receptor (LepR)-mediated anorexigenic pathway in hypothalamus is negatively regulated by a humoral factor unknown. Here, we identify an appetite-stimulating - ASRA that represents peripheral signal energy deficit orthosterically antagonizes LepR signaling. Asra encodes 8 kD protein abundantly selectively expressed adipose tissue to lesser extent, liver. associates with autophagy vesicles its...
We propose a scheme of ultraviolet (UV) communication system, with polar channel coding method. The bit error rate (BER) performance the UV code is analyzed by simulations and offline experiments, in contrast low-density parity-check (LDPC) scheme. Results suggest that has better BER than LDPC system.
Abstract Pancreatic cancer is associated with one of the highest and most severe forms cancer- cachexia amongst solid tumors. In an effort to further our understanding molecular etiology pancreatic cancer-associated cachexia, we have developed mouse models study adipose tissue wasting during Ductal Adenocarcinoma (PDAC) progression. these pursuits, identified a pro-cachectic factor, PTHrP, that produced secreted by PDAC tumor cells directly signals adipocytes facilitate wasting. Genetic...
In this paper, we propose symmetrical optical pulse position orthogonal space-time block code (SOPP-OSTBC) applied to m-ary positions modulation (m-PPM) without the use of a complex decoding scheme for multi-output (MIMO) based ultraviolet communication (UVC) system. Experiments are conducted with various key parameters and system performances ON-OFF keying (OOK) binary (2-PPM) compared. The results useful improving flexibility UVC systems.
A series of Ru-RE/γ-AL2O3 (RE = Ce, Pr, La, Sm, Tb or Gd) and Ru/γ-AL2O3 catalysts were prepared by impregnation method. The influence rare earths on the catalytic performance catalyst for water gas shift reaction was studied. characterized X-ray diffraction (XRD), temperature programmed reduction (TPR), desorption (TPD), CO chemisorption. results show that addition increases activity Ru based catalyst. Among these cerium is most remarkably. active surface area, improves...