A5101966285- Epilepsy research and treatment
- Neuroscience and Neuropharmacology Research
- Tuberous Sclerosis Complex Research
- Genetics and Neurodevelopmental Disorders
- Neurogenesis and neuroplasticity mechanisms
- Ion Channels and Receptors
- Pharmacological Effects and Toxicity Studies
- Ion channel regulation and function
- Polyomavirus and related diseases
- Glioma Diagnosis and Treatment
- S100 Proteins and Annexins
- Epigenetics and DNA Methylation
- Genetic and Kidney Cyst Diseases
- MicroRNA in disease regulation
- Neonatal and fetal brain pathology
- Chromatin Remodeling and Cancer
- Hedgehog Signaling Pathway Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Drug Transport and Resistance Mechanisms
- RNA regulation and disease
- Ion Transport and Channel Regulation
- Developmental Biology and Gene Regulation
- Connexins and lens biology
- Phagocytosis and Immune Regulation
- Neonatal Respiratory Health Research
Army Medical University
2014-2024
Xinqiao Hospital
2014-2024
University of Science and Technology of China
2024
Chongqing Medical University
2021-2023
Second Affiliated Hospital of Chongqing Medical University
2021-2023
Dalian Medical University
2021-2023
Chinese People's Armed Police Force Medical College Affiliated Hospital
2022
Southwest Hospital
2010
Abstract At least 50% of patients with tuberous sclerosis complex present intractable epilepsy; for these patients, resective surgery is a treatment option. Here, we report nationwide multicentre retrospective study and analyse the long-term seizure neuropsychological outcomes epilepsy in complex. There were 364 who underwent study. Patients’ clinical data, postoperative at 1-, 4-, 10-year follow-ups, preoperative intelligence quotients, quality life 1-year follow-up collected. The patients’...
Focal cortical dysplasias (FCDs) are increasingly recognized as important causes of medically intractable epilepsy. To understand the potential role interleukin 17 (IL-17) system in epileptogenesis FCDs, we studied expression patterns IL-17 15 FCD type Ia (FCDIa), 12 IIa (FCDIIa), and IIb (FCDIIb) lesions compared results with those cerebral cortex from 10 control patients. Protein levels IL-17, receptor (IL-17R), downstream factors pathway (nuclear factor-κB activator 1 [NFκB; ACT1]...
Focal cortical dysplasia type IIb (FCD IIb) and tuberous sclerosis complex (TSC) are well-recognized causes of chronic intractable epilepsy in children. Accumulating evidence suggests that activation the microglia/macrophage concomitant inflammatory response FCD TSC may contribute to initiation recurrence seizures. The membrane glycoproteins CD47 CD200, which highly expressed neurons other cells, mediate inhibitory signals through their receptors, signal regulatory protein α (SIRP-α) CD200R,...
A hallmark of temporal lobe epilepsy (TLE) is brain inflammation accompanied by neuronal demise. Accumulating evidence demonstrates that Rev-Erbα involved in regulating neuroinflammation and determining the fate neurons. Therefore, we studied expression cellular distribution epileptogenic zone TLE effect treatment with specific agonist SR9009 pilocarpine model.The pattern was investigated western blotting, immunohistochemistry, immunofluorescence labeling patients TLE. Next, effects on...
Tuberous sclerosis complex (TSC) and focal cortical dysplasia type IIb (FCDIIb) are characterized by epilepsy-associated cerebral malformations. To understand the potential role of inflammatory cytokine interleukin 6 (IL-6) in pathogenesis these lesions, we analyzed IL-6 system TSC FCDIIb lesions control cortex (CTX). Greater messenger RNA protein levels its receptors (i.e. receptor [IL-6R] glycoprotein 130 [gp130]) were observed versus CTX. Immunohistochemical analyses indicated that IL-6R...
Epigenetics underlying refractory epilepsy is poorly understood, especially in patients without distinctive genetic alterations. DNA methylation may affect gene expression affecting sequences. Herein, we analyzed genome-wide and brain tissues of 10 with using methylated immunoprecipitation linked sequencing mRNA Sequencing. Diverse distribution differentially genes was found X chromosome, while appeared rarely Y chromosome. 62 expressed genes, such as MMP19, AZGP1, DES, LGR6 were correlated...
Focal cortical dysplasia (FCD) is a major cause of intractable epilepsy in children however the mechanisms underlying pathogenesis FCD and induced remain unclear. Increasing evidence suggests that large-pore ion channels, pannexin 1 (Panx1) 2 (Panx2), are involved brain development. In this study, we investigated expression Panx1 Panx2 surgical samples from patients with type Ia (FCDIa), IIa (FCDIIa), IIb (FCDIIb) age-matched autopsy control samples. We found mRNA protein levels were both...
Abstract Background Temporal lobe epilepsy (TLE) is the most common drug-resistant in adults, with pathological mechanisms remaining to be fully elucidated. Fibroblast Growth Factor 13 (FGF13) encodes an intracellular protein involved microtubule stabilization and regulation of voltage-gated sodium channels (VGSCs) function. FGF13 mutation has been identified patients inherent seizure, suggesting a potential association between etiology TLE. Here, we set explore role Results We found that...
Cortical dysplasia accounts for at least 14% of epilepsy cases, and is mostly seen in children. However, the understanding molecular mechanisms pathogenesis underlying cortical limited. The aim this cross-sectional study to identify potential key molecules by screening proteins expressed brain tissues childhood patients with using isobaric tags relative absolute quantitation-based tandem mass spectrometry compared controls, several differentially that are not reported be associated...
Focal cortical dysplasia type IIb (FCDIIb) and tuberous sclerosis complex (TSC) are typical causes of developmental delay refractory epilepsy. G-protein-coupled receptor 30 (GPR30) is a specific estrogen that critical in neurodevelopment, neuroinflammation, neuronal excitability, suggesting it plays potential role the epilepsy patients with FCDIIb TSC. Therefore, we investigated GPR30 We found expression its downstream protein kinase A (PKA) pathway were decreased negatively correlated...
Focal cortical dysplasia (FCD) is a well-known cause of medically intractable epilepsy. To understand the potential role inflammatory cytokine interleukin 2 (IL-2) in pathogenesis FCD, we investigated expression patterns IL-2 and its receptors (IL-2Rs) FCD control samples that included epileptic neocortex from mesial temporal lobe epilepsy patients nonepileptic normal cortex (CTX). Greater mRNA protein levels IL-2Rs were observed versus CTX samples. Moreover, was significantly higher II than...
Summary Aim Focal cortical dysplasia ( FCD ) represents a well‐known cause of medically intractable epilepsy. Studies found that transient receptor potential vanilloid 4 TRPV 4) may participate in the occurrence seizures. This study investigated expression patterns and cascade regulate functional state neurons. Methods Thirty‐nine surgical specimens from patients 10 age‐matched control samples autopsies were included this study. Protein distribution detected by Western blot,...
Temporal lobe epilepsy (TLE) is the most common intractable in adults, and elucidation of underlying pathological mechanisms needed. Voltage-gated chloride channels (ClC) play diverse physiological roles neurons. However, less known regarding their functions epilepogenesis TLE.ClC-mediated current spontaneous inhibitory synaptic currents (sIPSC) hippocampal neurons epileptic lesions were investigated by electrophysiological recording. The EEG data analyzed Z-scored wavelet Fourier...