A5100723172- Neuroscience and Neuropharmacology Research
- S100 Proteins and Annexins
- Receptor Mechanisms and Signaling
- Nuclear Receptors and Signaling
- Adenosine and Purinergic Signaling
- Ion channel regulation and function
- Legume Nitrogen Fixing Symbiosis
- Pharmacological Effects of Natural Compounds
- Genetics and Neurodevelopmental Disorders
- ATP Synthase and ATPases Research
- Epigenetics and DNA Methylation
- Genetic Neurodegenerative Diseases
- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA Research and Splicing
- Genomics and Phylogenetic Studies
- Apelin-related biomedical research
- Allelopathy and phytotoxic interactions
- Botanical Studies and Applications
- Planarian Biology and Electrostimulation
- Fibroblast Growth Factor Research
- Biochemical effects in animals
- Carbon and Quantum Dots Applications
- Ion Transport and Channel Regulation
- Cellular transport and secretion
Xinqiao Hospital
2021-2024
Army Medical University
2011-2024
Chinese PLA General Hospital
2023-2024
PLA Academy of Military Science
2023
Zhongkai University of Agriculture and Engineering
2022
Air Force Medical University
2021
Heze University
2018
Huizhou Central People's Hospital
2018
Tottori University
2017
First Hospital of China Medical University
2012-2015
Exposure to extremely low-frequency electromagnetic fields (ELF-EMFs) can enhance hippocampal neurogenesis in adult mice. However, little is focused on the effects of ELF-EMFs embryonic neurogenesis. Here, we studied potential neural stem cells (eNSCs). We exposed eNSCs ELF-EMF (50 Hz, 1 mT) for 1, 2, and 3 days with 4 hours per day. found that eNSC proliferation maintenance were significantly enhanced after exposure medium. increased ratio differentiated neurons promoted neurite outgrowth...
To clarify the mechanisms of interaction between adenosine A(1) receptor (A1-R) and A(2) (A2-R) on neurotransmitter release, this study determined functional interactions among receptors (AD-Rs), voltage-sensitive Ca(2+) channels (VSCCs), protein kinases (PKs), synaptic proteins [N-ethylmaleimide-sensitive factor (NSF) attachment (SNAP) receptors] hippocampal serotonin release using in vivo microdialysis freely moving rat. Basal was regulated by two complexes: N-type VSCC...
Quantitative real-time PCR (qPCR) is an indispensable technique for gene expression analysis in modern molecular biology. The selection and evaluation of suitable reference genes a prerequisite accurate analysis. Schimasuperba valuable tree species that environmentally adaptable highly fire-resistant. In this study, 12 candidate were selected to check their stability different tissues under abiotic stresses: cold stress, salt drought stress by ΔCt, geNorm, NormFinder, BestKeeper, RefFinder....
Temporal lobe epilepsy (TLE) is the most common intractable in adults, and elucidation of underlying pathological mechanisms needed. Voltage-gated chloride channels (ClC) play diverse physiological roles neurons. However, less known regarding their functions epilepogenesis TLE.ClC-mediated current spontaneous inhibitory synaptic currents (sIPSC) hippocampal neurons epileptic lesions were investigated by electrophysiological recording. The EEG data analyzed Z-scored wavelet Fourier...
Abstract Background Temporal lobe epilepsy (TLE) is the most common drug-resistant in adults, with pathological mechanisms remaining to be fully elucidated. Fibroblast Growth Factor 13 (FGF13) encodes an intracellular protein involved microtubule stabilization and regulation of voltage-gated sodium channels (VGSCs) function. FGF13 mutation has been identified patients inherent seizure, suggesting a potential association between etiology TLE. Here, we set explore role Results We found that...
Tuberous sclerosis complex (TSC) and focal cortical dysplasia (FCD) type IIb are the predominant causes of drug-refractory epilepsy in children. Dysmorphic neurons (DNs), giant cells (GCs), balloon (BCs) most typical pathogenic profiles lesions TSC FCD patients. However, mechanisms underlying pathological processes remain obscure. The Plexin-B2-Sema4C signalling pathway plays critical roles neuronal morphogenesis corticogenesis during development central nervous system. role Plexin-B2 system...
Abstract Background Focal cortical dysplasia type IIb (FCDIIb) and tuberous sclerosis complex (TSC) show persistent neuroinflammation, which promotes epileptogenesis epilepsy progression, suggesting that endogenous resolution of inflammation is inadequate to relieve neuronal network hyperexcitability. To explore the potential roles formyl peptide receptor 2 (FPR2), a key regulator resolution, in caused by FCDIIb TSC, we examined expression cellular distribution FPR2. Method The FPR2 nuclear...
Abstract Introduction Sotos syndrome (SS) is an overgrowth disease characterized by distinctive facial features, advanced bone age, macrocephaly, and developmental delay associated with alterations in the NSD1 gene. Here, we report a case of 4‐year‐old female child SS caused gene nonsense mutation. Methods Whole‐exome sequencing (WES) was applied for probands her parents. Sanger used to confirm We performed literature review using PubMed found 12 articles 14 patients who presented SS....
Wu, Lijuan; Huang, Yinglin; Li, Jingying; Zhao, Hong; Du, Jin, Qiu; Xiaofeng; Ma, Huan; Zhu, Gang Author Information
Glioblastoma multiforme (GBM) is an aggressive brain tumor with a rather short survival time. Mutation of p53 has been observed and reported to play critical roles in the progression GBM. However, pathological mechanisms are still unclear. This study was designed identify role miR-154 mediating biological functions glioblastoma multiforme.In current study, expression GBM tissue samples cell lines wt-p53 or mutant evaluated. The migration, invasion epithelial-mesenchymal transition were...
To explore the protective effect of glycyrrhizin in rats with nephrotic syndrome (NS) induced by adriamycin (ADR).36 Sprague Dawley (SD) male were divided into control, untreated and treatment groups. The NS rat model was established injecting ADR twice Rats group fed intragastric administration for 7 days. Changes following indices observed three groups before 4 weeks after treatment: 24 h urine protein quantitation (UPr), serum cholesterol (Ch), albumin (Alb), blood urea nitrogen (BUN),...
To investigate the protective effect of ganoderan on renal damage in rat models with chronic glomerulonephritis induced by adriamycin.48 healthy Sprague-Dawley rats were randomly divided into three groups: control, nephritic model and treatment groups. Changes following indices groups observed 6 weeks after treatment: 24-hour urine protein, albumen, serum creatinine, cholesterol. Histopathological observations cortex made light electron microscopy.Compared controls, levels protein...
Relapse poses a significant challenge after the initial effectiveness of adrenocorticotropic hormone treatment in infantile epileptic spasms syndrome (IESS), involving complex neuronal oscillations interactions. Phase-amplitude coupling (PAC) extensively characterizes mutual interactions among rhythmic activities pathological conditions. However, relapse-related PACs between brain regions across various frequencies remain unclear. Here, noise-assisted multivariate empirical mode...