A5103157559- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Autophagy in Disease and Therapy
- Pancreatic and Hepatic Oncology Research
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Endoplasmic Reticulum Stress and Disease
- Nuclear Receptors and Signaling
- Cancer Genomics and Diagnostics
- Advancements in Solid Oxide Fuel Cells
- Head and Neck Cancer Studies
- Immune cells in cancer
- Osteoarthritis Treatment and Mechanisms
- Circular RNAs in diseases
- Parkinson's Disease Mechanisms and Treatments
- Nerve injury and regeneration
- Lung Cancer Treatments and Mutations
- RNA Research and Splicing
- Aquaculture Nutrition and Growth
- interferon and immune responses
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Reproductive biology and impacts on aquatic species
- Heat shock proteins research
Jinan Stomatological Hospital
2015-2025
Air Force Medical University
2016-2024
Tang Du Hospital
2021-2022
Environmental Protection Agency
2009-2015
University of Science and Technology Beijing
2009-2011
Taizhou University
2010
Abstract Endoplasmic reticulum (ER) stress is involved in many cellular processes. Emerging evidence suggests that ER can trigger autophagy; however, the mechanisms by which regulates autophagy and its role this condition are not fully understood. HIV Tat-interactive protein, 60 kDa (TIP60) a newly discovered acetyltransferase modulate flux activating ULK1 upon growth factor deprivation. In study, we investigated induces autophagy. We showed activates glycogen synthase kinase-3 β (GSK3 )....
Previous studies have demonstrated that long noncoding RNA cancer susceptibility candidate 2 (lncRNA CASC2) is frequently downregulated in several types of tumors and functions as a tumor-suppressive factor. However, the clinical significance function CASC2 human glioma remain largely unknown. The purpose this study was to identify values CASC2, well investigate potential molecular mechanisms glioma.This retrospective first analyzed expression levels using quantitative real-time polymerase...
Colorectal cancer (CRC) is one of the most malignant cancers and its pathological mechanism largely unknown. Unfolded protein response ferroptosis are both critical factors involved in CRC development. However, their relationship remains to be explored. In this study, erastin was used induce cells. Ferroptosis confirmed by detection glutathione, malondialdehyde, lipid reactive oxygen species. The datasets were analyzed using R software, GEPIA2, TIMER2.0. results indicated that GPX4 decreased...
As part of a research effort examining system-wide responses the hypothalamic-pituitary-gonadal (HPG) axis in fish to endocrine-active chemicals (EACs) with different modes action, zebrafish (Danio rerio) were exposed 25 or 100 microg/L aromatase inhibitor fadrozole for 24, 48, 96 h. Global transcriptional response brain and ovarian tissue was compared that control using commercially available, 22,000-gene oligonucleotide microarray. Transcripts altered functionally linked differentiation,...
Pancreatic cancer (PAAD) is one of the most malignant cancers and immune microenvironment has been proved to be involved in pathogenesis PAAD. m6A modification, related expression regulators, participates development multiple cancers. However, correlation between regulators was largely unknown And because small sample size pancreatic TCGA database, it not enough draw a convincing conclusion. In present study, we downloaded seven datasets with survival data removed batch effects among these...
Objective: To explore the expression of transferrin receptor (TFRC) gene in pancreatic cancer and to analyze pathogenesis immunotherapy TFRC patients using bioinformatics methods. Methods: We used public data from genome atlas (TCGA) omnibus databases level patients. At same time, we analyzed correlation between patient survival, further survival time with different clinicopathological characteristics. Co-expressed genes pathway enrichment analyses were mechanism occurrence development...
Transmembrane protein 43 (TMEM43), a member of the transmembrane subfamily, plays critical role in initiation and development cancers. However, little is known concerning biological function molecular mechanisms TMEM43 pancreatic cancer. In this study, expression levels were analyzed cancer samples compared with control samples. The relationship disease-free survival (DFS) overall (OS) assessed patients. vitro vivo assays performed to explore Coimmunoprecipitation (co-IP) followed by mass...
Abstract Sevoflurane, a typical inhaled anesthetic, is widely used in patients of all ages during surgery. The negative effects, such as inducing cell death and damaging spatial memory, sevoflurane on neurodevelopment have raised increasing concerns recent years. However, the molecular mechanism remains unclear. This study focused crucial role endoplasmic reticulum (ER) stress sevoflurane‐induced hippocampal injury. Three‐week‐old rats were exposed to or control air for 5 h with without ER...
Pancreatic cancer (PAC) is one of the most malignant types and immunotherapy has emerged as a promising treatment option. PAC cells undergo metabolic reprogramming, which thought to modulate tumor microenvironment (TME) affect outcomes. However, landscape its association with TME remains largely unexplored. We characterized based on 112 pathways constructed novel metabolism-related signature (MBS) using data from 1,188 patients PAC. evaluated predictive performance MBS for outcomes in 11...
Oral cavity cancer is common worldwide. Furthermore, the epidermal growth factor receptor (EGFR) signaling pathway considered to be constitutively activated in oral cancers. Paclitaxel widely accepted as an antitumor drug it effectively inhibits cell cycle. This study predominantly explores possible molecule mechanism of paclitaxel on treatment. Cell viability was first detected using MTT assay. apoptosis examined by Hoechst staining and flow cytometry annexin-V propidium iodide kit....
Abstract MiRNAs, a group of powerful modulator gene expression, participate in multiple cellular processes under physiological and pathological conditions. Emerging evidence shows that Drosha, which controls the initial step canonical miRNA biogenesis, is involved modulating cell survival death models several diseases. However, role Drosha Parkinson’s disease (PD) has not been well established. Here, we show level decreases 6-OHDA-induced animal PD. 6-OHDA induced p38 MAPK-dependent...
Characterizations of rat mandibular second molar extraction socket with significantly different buccal and lingual alveolar ridge width remain unclear.To observe alterations in the after molars, to examine processes healing an experimental model absorption preservation.Eighteen Wistar rats were included divided into six groups regarding time study. Bilateral molars extracted. The tooth sockets took 0, 1.5, 2, 3, 4 8 weeks healing. Histological observation, tartrate-resistant acidic...
AKR7A3 is a member of the aldo-keto reductase (AKR) protein family, whose primary purpose to reduce aldehydes and ketones generate secondary alcohols. It has been reported that downregulated in pancreatic cancer (PC). However, mechanism underlying effects PC remains largely unclarified. Here, we explored biological function, molecular clinical relevance ductal adenocarcinoma (PDAC). expression was PDAC compared with adjacent normal tissues, lower related poor prognosis. In addition, our...
Pancreatic adenocarcinoma (PAAD) is one of the most malignant cancers and has a poor prognosis. As critical RNA modification, 5-methylcytosine (m5C) been reported to regulate tumor progression, including PAAD progression. However, comprehensive analysis m5C regulators in lacking.In present study, datasets were obtained from Gene Expression Omnibus (GEO), The Cancer Genome Atlas (TCGA), International Consortium (ICGC), ArrayExpress databases. expression pattern analyzed patients divided into...
Microglia play an essential role in the central nervous system immune response. The transcription factor myocyte enhancer factor-2 D (MEF2D) is known to participate stress regulation various cell types and easily activated microglia. MEF2D has been shown transcriptionally regulate several cytokine genes cells directly regulates inflammatory response, suggesting that may act as a key stimulus response regulator of microglia involved brain microhomeostasis. To uncover molecular mechanism...
Glioblastoma multiforme (GBM) is an aggressive brain tumor with a rather short survival time. Mutation of p53 has been observed and reported to play critical roles in the progression GBM. However, pathological mechanisms are still unclear. This study was designed identify role miR-154 mediating biological functions glioblastoma multiforme.In current study, expression GBM tissue samples cell lines wt-p53 or mutant evaluated. The migration, invasion epithelial-mesenchymal transition were...
The roles and molecular mechanisms of tumor necrosis factor-α-induced protein 8-like 2 (TIPE2) in periodontitis remain largely unknown. Objective This study aimed to determine the expression TIPE2 NF-κB p65 rat Porphyromonas gingivalis-induced periodontics vivo. Methodology Periodontal inflammation alveolar bone resorption were analyzed using western blotting, micro-computed tomography, TRAP staining, immunohistochemistry, immunofluorescence. THP-1 monocytes stimulated 1 μg/ml Pg....
Synovitis is characterized by the infiltration of inflammatory cells and often accompanies pathological progression clinical symptoms affecting temporomandibular joint (TMJ), such as pain, snapping, limited mouth opening. It has been suggested that signal transduction pathway resultant proinflammatory mediators play important roles in pathogenesis synovitis. Therefore, this present research, we aimed to investigate changes expressions stromal cell-derived factor 1 (SDF-1) interleukin (IL)-1β...