A5101433079- Neuroscience and Neuropharmacology Research
- Epilepsy research and treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Ion channel regulation and function
- Nerve injury and regeneration
- Head and Neck Surgical Oncology
- Nuclear Receptors and Signaling
- Traumatic Brain Injury and Neurovascular Disturbances
- Parkinson's Disease Mechanisms and Treatments
- Lipid Membrane Structure and Behavior
- Ferroptosis and cancer prognosis
- Cerebrospinal fluid and hydrocephalus
- Meningioma and schwannoma management
- Neuropeptides and Animal Physiology
- Anesthesia and Neurotoxicity Research
- Endoplasmic Reticulum Stress and Disease
- Neonatal and fetal brain pathology
- Venous Thromboembolism Diagnosis and Management
- Cancer Immunotherapy and Biomarkers
- High Altitude and Hypoxia
- Cannabis and Cannabinoid Research
- Single-cell and spatial transcriptomics
- Neurological Disease Mechanisms and Treatments
- Glioma Diagnosis and Treatment
- MicroRNA in disease regulation
Air Force Medical University
2015-2024
Tang Du Hospital
2016-2024
Army Medical University
2013-2022
Chongqing Medical University
2021-2022
Second Affiliated Hospital of Chongqing Medical University
2021-2022
Dalian Medical University
2021-2022
China XD Group (China)
2016
China Medical University
2013-2014
Southwest Hospital
2013
First Hospital of China Medical University
2013
Staphylococcal enterotoxins (SEs) produced by Staphylococcus aureus are the most recognizable bacterial superantigenic toxins causing food poisoning in humans throughout world. However, it remains unclear how SEs induce emesis and its emetic signal pathway. We investigated a mechanism of SEA-induced using small animal model, house musk shrew. animals was inhibited 5-hydroxytryptamine (5-HT) synthesis inhibitor 5-HT(3) receptor antagonist. SEA could increase 5-HT release intestine....
AP-3 is a member of the adaptor protein (AP) complex family that regulates vesicular transport cargo proteins in secretory and endocytic pathways. There are two isoforms AP-3: ubiquitously expressed AP-3A neuron-specific AP-3B. Although physiological role has recently been elucidated, AP-3B remains unsolved. To address this question, we generated mice lacking μ3B, subunit μ3B−/− suffered from spontaneous epileptic seizures. Morphological abnormalities were observed at synapses these mice....
Neuroinflammatory responses have been recognized as an important aspect in the pathogenesis of Parkinson's disease (PD). Transcriptional regulation plays a critical role process inflammation. Transcription factor myocyte enhancer 2D (MEF2D) is identified central transmission extracellular signals and activation genetic programs response to wide range stimuli several cell types, including neurons. But its presence function microglia not reported. We therefore investigated effect MEF2D...
Midbrain dopamine (DA) neurons are essential for maintaining multiple brain functions. These have also been implicated in relation with diverse neurological disorders. However, how these developed from neuronal stem cells (NSCs) remains largely unknown. In this study, we provide both vivo and vitro evidence that the thyroid hormone, an important physiological factor development, promotes DA neuron differentiation embryonic ventral midbrain (VM) NSCs. We find hormone deficiency during...
To elucidate mechanisms of hippocampal serotonin release and possible clinical action carbamazepine (CBZ), we determined interaction between antagonists N‐type (ω‐conotoxin GVIA:GVIA), P‐type (ω‐agatoxin IVA:IVA) Ca 2+ channels, Na + channel (tetrodotoxin: TTX) CBZ on basal, ‐ K ‐evoked releases, using microdialysis in freely moving rats. Basal was reduced by TTX, GVIA IVA (GVIA>IVA). but unaffected TTX IVA. (GVIA<IVA). inhibited actions respective basal without affecting release....
Abstract Sevoflurane, a typical inhaled anesthetic, is widely used in patients of all ages during surgery. The negative effects, such as inducing cell death and damaging spatial memory, sevoflurane on neurodevelopment have raised increasing concerns recent years. However, the molecular mechanism remains unclear. This study focused crucial role endoplasmic reticulum (ER) stress sevoflurane‐induced hippocampal injury. Three‐week‐old rats were exposed to or control air for 5 h with without ER...
Calcium (Ca2+) dyshomeostasis induced by endoplasmic reticulum (ER) stress is an important molecular mechanism of selective dopaminergic (DA) neuron loss in Parkinson's disease (PD). Inositol 1,4,5-triphosphate receptors (IP3Rs) and ryanodine (RyRs), which are located on the ER surface, main endogenous Ca2+ release channels play crucial roles regulating homeostasis. However, these PD their effects function survival DA neurons remain unknown. In this study, using a 6-hydroxydopamine...
Intracerebral hemorrhage (ICH) is lethal but lacks effective therapies. Nicotinamide adenine dinucleotide (NAD+) a central metabolite indispensable for broader range of fundamental intracellular biological functions. Reduction NAD+ usually occurs after acute brain insults, and supplementation has been proven neuroprotective. P7C3-A20 novel compound featuring its ability to facilitate the flux NAD+. In this study, we sought determine potential therapeutic value in ICH. collagenase-induced ICH...
Oxidative stress and mitochondrial dysfunction play critical roles in ischemia/reperfusion (I/R) injury. DJ-1 is an endogenous antioxidant that attenuates oxidative maintains function, likely acting as a protector of I/R In the present study, we explored protective effect possible agonist, sodium phenylbutyrate (SPB), against injury by protecting via upregulation protein. Pretreatment with SPB upregulated protein level rescued injury-induced decrease about 50% both vivo vitro. also improved...
Abstract MiRNAs, a group of powerful modulator gene expression, participate in multiple cellular processes under physiological and pathological conditions. Emerging evidence shows that Drosha, which controls the initial step canonical miRNA biogenesis, is involved modulating cell survival death models several diseases. However, role Drosha Parkinson’s disease (PD) has not been well established. Here, we show level decreases 6-OHDA-induced animal PD. 6-OHDA induced p38 MAPK-dependent...
// Yuqian Li 1, * , Gang Zhu Wen Zeng Jiancai Wang 1 Zhihong Bao Bo Tian Dan Lu Xingye Zhang Guodong Gao and Lihong Department of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, 710038, China These authors contributed equally to this work Correspondence to: Li, email: 617336343@qq.com Gao, 332568488@qq.com Keywords: AB073614, glioma, long noncoding RNA, SOX7, Wnt/β-catenin Received: April 03, 2017 Accepted: June 28, Published: July 17, ABSTRACT Long RNA...
Phospholipase C-related, but catalytically inactive protein (PRIP) was first identified as a novel inositol 1,4,5-triphosphate binding protein. The PRIP-1 subtype is expressed predominantly in the central nervous system and binds directly to GABA type A receptor (GABA<sub>A</sub>-R) β-subunit several other proteins involved trafficking of GABA<sub>A</sub>-Rs plasma membrane. We found that knockout mouse showed an epileptic phenotype, confirmed by electroencephalogram. These ictal seizures...
The endocannabinoid (eCB) system is involved in pathways that regulate drug addiction and eCB-mediated synaptic plasticity has been linked with addictive behaviours. Here, we investigated the molecular mechanisms underlying changes eCB-dependent nucleus accumbens core (NAcc) following short-term withdrawal from repeated morphine treatment.Conditioned place preference (CPP) was used to evaluate rewarding effects of rats. Evoked inhibitory postsynaptic currents medium spiny neurons NAcc were...
The Wnt/β-catenin signaling pathway has been linked to many neurodegenerative diseases including Parkinson's disease (PD). A glycoprotein named Dickkopf-1 (Dkk1) can combine with the receptor complex on cell membrane inhibit signaling. Opioids, a series of compounds morphine, fentanyl and pentazocine, have reported contribute up-regulation Naloxone is an antagonist that used as antidote opioids through mu-opioid receptor. 1-methyl-4-phenylpyridinium (MPP+), which serves selective toxin for...