A5053064222- Neuroscience and Neuropharmacology Research
- Ion channel regulation and function
- Epilepsy research and treatment
- Cellular transport and secretion
- Receptor Mechanisms and Signaling
- Calcium signaling and nucleotide metabolism
- Temporomandibular Joint Disorders
- Neurological disorders and treatments
- Clinical Nutrition and Gastroenterology
- Infant Health and Development
- Neuroinflammation and Neurodegeneration Mechanisms
- Biotin and Related Studies
- Adenosine and Purinergic Signaling
- Photoreceptor and optogenetics research
- Orthopaedic implants and arthroplasty
- Lipid Membrane Structure and Behavior
- Oropharyngeal Anatomy and Pathologies
- Autoimmune and Inflammatory Disorders Research
- Neurotransmitter Receptor Influence on Behavior
- Liver Disease Diagnosis and Treatment
- Inflammasome and immune disorders
- Gastroesophageal reflux and treatments
- Dental Trauma and Treatments
- Oral and Craniofacial Lesions
- IL-33, ST2, and ILC Pathways
Unitika (Japan)
2019-2024
Hirosaki University
2007-2024
Kitano Hospital
2018
Nihon University
2011
National Center for Genetic Engineering and Biotechnology
2004
Asahi University
1991-1998
Harvard University
1978
Kyoto Prefectural University of Medicine
1978
Kyoto University
1978
Mutations of genes encoding alpha4, beta2, or alpha2 subunits (CHRNA4, CHRNB2, CHRNA2, respectively) nAChR [neuronal nicotinic ACh (acetylcholine) receptor] cause nocturnal frontal lobe epilepsy (NFLE) in human. NFLE-related seizures are seen exclusively during sleep and characterized by three distinct seizure phenotypes: "paroxysmal arousals," dystonia," "episodic wandering." We generated transgenic rat strains that harbor a missense mutation S284L, which had been identified CHRNA4 NFLE....
Phospholipase C-related, but catalytically inactive protein (PRIP) was first identified as a novel inositol 1,4,5-triphosphate binding protein. The PRIP-1 subtype is expressed predominantly in the central nervous system and binds directly to GABA type A receptor (GABA<sub>A</sub>-R) β-subunit several other proteins involved trafficking of GABA<sub>A</sub>-Rs plasma membrane. We found that knockout mouse showed an epileptic phenotype, confirmed by electroencephalogram. These ictal seizures...
Cytosol of the guinea pig adrenals was found to contain a protein kinase which dependent on presence both calcium and phospholipids (phosphatidylserine diolein), i.e., calcium/phospholipid-dependent (protein C). The peak C separated from type II cAMP-dependent by DE-52 chromatography. 12-0-Tetradecanoylphorbol-13-acetate (TPA) caused dose-dependent increments cortisol formation without affecting cAMP adrenocortical cells as well angiotensin did. TPA-activated production blocked addition...
Thiopurines are key drugs for inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's (CD). Recently, NUDT15 polymorphism (R139C, c.415C > T) has been shown to be associated with thiopurineinduced adverse events in Asian populations. In patients the C/T genotype, low-dose thiopurine treatment is recommended, but its long-term efficacy tolerability remain unclear. This study aimed uncover appropriate dosage of IBD genotype. A total 210 (103 UC 107 CD) determined have...
In the past decades, several mutant genes that encode ion channel subunit proteins or their functionally-related have been identified in pedigrees of idiopathic epilepsy. To explore pathogenesis and pathophysiology epilepsy syndrome, functional abnormalities transmission genetic animal models bearing should be analyzed. spite these efforts, it is important to identify most suitable for exploration epileptogenesis ictogenesis, as well development novel antiepileptic drugs. literature on...
Although the polymerization reaction in light-cured orthodontic adhesive continues for some time after light irradiation, it is unclear whether insufficiently irradiated develops sufficient bond strength. This vitro study examined maturation of strength exposure a variety doses. Large metal brackets were bonded to enamel 288 bovine mandibular incisors by irradiation at two intensities (200 and 400 mW/cm2) three times (3, 5, 10 seconds) using adhesives (TB, OP, BOB). Shear strengths remnant...
gamma-Aminobutyric acid (GABA) receptors were visualized in mouse spinal cord explant cultures by [3H]muscimol autoradiography over certain small neurons of the dorsal horn grey matter, interneuronal neuropil and ventral horns, (rarely) clusters on processes anterior cells. Specificity was indicated control experiments inhibition binding after pretreatment with GABA or a analogue, 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol (THIP, isoxazole 16), receptor antagonists bicuculline...
Indigo naturalis, a herbal medicine purified from indigo-containing plants, such as Strobilanthes cusia, Isatis tinctoria, and Polygonum tinctorium, has been reported to be useful in the treatment of ulcerative colitis by activating aryl hydrocarbon receptor. However, receptor pathway causes crucial side effects, pulmonary arterial hypertension. Although P. tinctorium is one plant derivatives indigo it not identical it. To date, pure leaves have ameliorate colitis. Therefore, we investigated...
A relationship between treatment outcomes and intestinal microbiota in patients with inflammatory bowel diseases has been demonstrated. Cyclosporine leads to rapid improvement severe ulcerative colitis. We hypothesized that the potent effects of cyclosporine would be exerted through relationships epithelial cells (IECs) host microbiota. The present study was designed elucidate on monocarboxylate transporter 1 (MCT1) regulation butyrate uptake by IECs. Colitis induced C57BL6 mice via...