A5006855702- Neuropeptides and Animal Physiology
- Receptor Mechanisms and Signaling
- Neuroendocrine regulation and behavior
- Pain Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Nitric Oxide and Endothelin Effects
- Cancer, Stress, Anesthesia, and Immune Response
- Chemical Synthesis and Analysis
- Stress Responses and Cortisol
- Anesthesia and Pain Management
- Hormonal Regulation and Hypertension
- Ion channel regulation and function
- Electrolyte and hormonal disorders
- Neuroscience of respiration and sleep
- Anesthesia and Neurotoxicity Research
- Circadian rhythm and melatonin
- Neurotransmitter Receptor Influence on Behavior
- Nicotinic Acetylcholine Receptors Study
- X-ray Diffraction in Crystallography
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Pharmacological Receptor Mechanisms and Effects
- Pediatric Pain Management Techniques
- Regulation of Appetite and Obesity
- Peptidase Inhibition and Analysis
- Vitamin K Research Studies
Fukuoka University
2005-2020
The University of Tokyo
1964-2013
RIKEN Advanced Science Institute
2013
Tokyo University of the Arts
2013
Akita Red Cross Hospital
1992-2006
Tokyo University of Science
1999-2001
Dokkyo University
1994-2000
Dokkyo Medical University Saitama Medical Center
1994-1999
Pharmac
1999
Kagoshima University
1998
Abstract Fatty acid synthase (FAS) has been found to be overexpressed in a wide range of epithelial tumors, including breast cancer. Pharmacologic inhibitors FAS cause apoptosis cancer cells and result decreased tumor size vivo. However, how the inhibition induces remains largely unknown. To understand apoptotic pathway resulting from direct FAS, we treated with or without small interfering RNA (siRNA) followed by microarray analysis. Our results indicated that proapoptotic genes BNIP3,...
To examine the pharmacology of spinal alpha receptor which modulates nociceptive transmission, antinociceptive effects (52.5 degrees C hot plate; HP) three i.t. administered alpha-2-preferring agonists [dexmedetomidine (DMET); clonidine (CLON) and ST-91] were determined. The antagonist potency atipamezole (ATI), idazoxan (IDAZ), yohimbine (YOH) prazosin (PRA), adrenergic antagonists with differing profiles, then examined for each agonists. produced a dose-dependent block HP response ED50...
Abstract PTEN (phosphatase and tensin homologue deleted on chromosome 10) has been shown to be inactivated in a wide variety of cancers, the role this gene as tumor suppressor well established. On other hand, results recent animal studies clinical evidence indicate that is also involved metastasis suppression. Although known play key controlling cell growth apoptosis, how exerts function remains largely unknown. Recently, microarray analysis identified Drg-1 (differentiation related 1) one...
The tumor metastasis suppressor gene Drg-1 has been shown to suppress without affecting tumorigenicity in immunodeficient mouse models of prostate and colon cancer. Expression also found have a significant inverse correlation with or invasiveness various types human However, how exerts its function remains unknown. In the present study, elucidate mechanism action gene, we did microarray analysis that induction significantly inhibited expression activating transcription factor (ATF) 3, member...
Cytokines such as interleukins are known to be involved in the development of neuropathic pain through activation neuroglia. However, role chemokine (C-C motif) ligand 1 (CCL-1), a well-characterized secreted by activated T cells, nociceptive transmission remains unclear. We found that CCL-1 was upregulated spinal dorsal horn after partial sciatic nerve ligation. Therefore, we examined actions recombinant on behavioural score, synaptic transmission, glial cell function and cytokine...
Mutations of genes encoding alpha4, beta2, or alpha2 subunits (CHRNA4, CHRNB2, CHRNA2, respectively) nAChR [neuronal nicotinic ACh (acetylcholine) receptor] cause nocturnal frontal lobe epilepsy (NFLE) in human. NFLE-related seizures are seen exclusively during sleep and characterized by three distinct seizure phenotypes: "paroxysmal arousals," dystonia," "episodic wandering." We generated transgenic rat strains that harbor a missense mutation S284L, which had been identified CHRNA4 NFLE....
To examine the relative efficacy of spinally administered alpha-2 adrenergic agonists [dexmedetomidine, clonidine and ST-91 (2-[2,6- diethylphenylamino]-2-imidazole)] on 52.5 degrees C hot plate in rats, EEDQ (N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline), an irreversible antagonist, was intrathecally (in doses 0, 8.1, 81 810 nmol) 24 hr before administration these agonists. alone results acute mild hyperalgesic effect. Intrathecal dexmedetomidine, result a dose-dependent increase response...
The effects of a novel tachykinin NK1-receptor antagonist HSP-117 [(2S,3S)-3-[(5-isopropyl-2,3-dihydrobenzofuran-7-yl)methyl]amino-2-phenylpiperidine dihydrochloride] on cisplatin-induced pica, i.e., the eating nonnutritive substances such as kaolin were examined in rats. inhibited intake dose-dependent manner for 2 days. 5-HT3-receptor ondansetron only first day, but not second day. These results indicate that day is related to both 5-HT3- and NK1 receptors, while receptor involved Thus,...