A5036210422- Inflammatory Bowel Disease
- Gastrointestinal Bleeding Diagnosis and Treatment
- Microscopic Colitis
- Autoimmune and Inflammatory Disorders
- Clinical Nutrition and Gastroenterology
- Gastric Cancer Management and Outcomes
- Esophageal and GI Pathology
- Autoimmune and Inflammatory Disorders Research
- Gastrointestinal disorders and treatments
- Gut microbiota and health
- Colorectal Cancer Treatments and Studies
- Inflammasome and immune disorders
- Gastroesophageal reflux and treatments
- Colorectal Cancer Screening and Detection
- interferon and immune responses
- Liver Disease Diagnosis and Treatment
- Retinoids in leukemia and cellular processes
- Pancreatic and Hepatic Oncology Research
- Esophageal Cancer Research and Treatment
- Nutrition and Health in Aging
- Antioxidant Activity and Oxidative Stress
- Eosinophilic Esophagitis
- Enhanced Recovery After Surgery
- Immunodeficiency and Autoimmune Disorders
- Immune Cell Function and Interaction
Hirosaki University
2014-2024
McMaster University
2009
Kobe City Medical Center General Hospital
1991
Capsule endoscopy has been widely used as a non-invasive diagnostic tool for small or large intestinal lesions. In recent years, automated lesion detection systems using machine learning have devised. This study aimed to develop an system capsule endoscopic severity in patients with ulcerative colitis along the entire length of colon ResNet50. videos from were collected prospectively. Each single examination video file was partitioned into four segments: cecum and ascending colon, transverse...
Cyclosporine is a potent immunomodulator and has beneficial effect in the treatment of ulcerative colitis (UC). We analyzed mechanism effects cyclosporine on regulation epithelial apoptosis via TGF-beta-related signaling, because balance between regeneration cells seems to be key factor maintain intestinal homeostasis. For this purpose, was induced by 4% dextran sulfate sodium (DSS), with anti-TGF-beta antibody assessed. Treatment ameliorated body weight loss, mucosal destruction,...
Background: Maintenance of mucosal healing may lead to a better outcome in patients with Crohn's disease (CD). Magnetic resonance diffusion-weighted imaging (MR-DWI) scans 1 year after infliximab (IFX) induction therapy were assessed as predictors maintained response, or remission, through 3 years treatment CD. Summary: MR-DWI and endoscopy data prospectively collected throughout IFX treatment. Altogether, 86 lesions from 13 given (weeks 0, 2 6) maintenance (5 mg/kg every 8 weeks beginning...
Currently, the number of patients treated with immune-checkpoint inhibitor involving nivolumab is increasing. Nevertheless, it causes various immune-related adverse events (irAEs). Here, we report case a patient who underwent long-term follow-up after suffering from nivolumab-associated colitis. The was 57-year-old man resection bladder tumor. Following surgery, lymph node metastasis detected, and he by nivolumab. Two months treatment nivolumab, complained bloody diarrhea. Colonoscopy...
Dietary fat strongly influences the intestinal mucosal barrier, which protects against invading pathogenic bacteria. A high-fat diet (HFD) compromises integrity of epithelial tight junctions (TJs) and reduces mucin production, leading to barrier disruption metabolic endotoxemia. It has been shown that active constituents indigo plants can protect inflammation; however, their protective role in HFD-induced damage remains unknown. The present study aimed investigate effects Polygonum...
Recently, the importance of achieving clinical and deep remissions with mucosal healing (MH) has been demonstrated as a therapeutic goal to avoid Crohn's disease (CD) surgical operations. Although ileocolonoscopy (CS) is considered gold standard, there are increasing reports on benefits capsule endoscopy (CE) serum leucine-rich α2-glycoprotein (LRG) for evaluating small-bowel lesions in CD. We evaluated data 20 patients CD who underwent CE our department between July 2020 June 2021 whose LRG...
Thiopurines are key drugs for inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's (CD). Recently, NUDT15 polymorphism (R139C, c.415C > T) has been shown to be associated with thiopurineinduced adverse events in Asian populations. In patients the C/T genotype, low-dose thiopurine treatment is recommended, but its long-term efficacy tolerability remain unclear. This study aimed uncover appropriate dosage of IBD genotype. A total 210 (103 UC 107 CD) determined have...
We describe herein a case of severe relapsed pyoderma gangrenosum (PG) concomitantly with pouchitis treated by tacrolimus. A 25-year-old woman had undergone proctocolectomy construction ileo-anal pouch surgery for refractory ulcerative colitis (UC). She first developed PG pouchitis, and infliximab (IFX) was administered to induce remission due resistance glucocorticoid therapy. After achieving remission, IFX stopped. Five years later, skin ulcers recurred treatment 30 mg oral prednisolone...
Vitamin A ensures intestinal homeostasis, impacting acquired immunity and epithelial barrier function; however, its role in innate is mostly unknown. Here, we studied the impact of vitamin different dextran sulfate sodium (DSS)-induced colitis animal models. Interestingly, more severe DSS-induced was observed A-deficient (VAD) mice than A-sufficient (VAS) mice; same VAD combined immunodeficient lacking T/B cells. Remarkably, IL-1β production, LC3B-II expression, inflammasome activity lamina...
Indigo naturalis, a herbal medicine purified from indigo-containing plants, such as Strobilanthes cusia, Isatis tinctoria, and Polygonum tinctorium, has been reported to be useful in the treatment of ulcerative colitis by activating aryl hydrocarbon receptor. However, receptor pathway causes crucial side effects, pulmonary arterial hypertension. Although P. tinctorium is one plant derivatives indigo it not identical it. To date, pure leaves have ameliorate colitis. Therefore, we investigated...
Myelodysplastic syndromes (MDSs) are a group of myeloid neoplasms characterized by blood cell deformation and dysfunction, MDS with trisomy 8 is closely linked intestinal Behçet's-like diseases. Intestinal disease refractory to conventional therapies, including prednisolone, immunomodulators, anti-tumor necrosis factor α agents. Here, we describe 56-year-old woman ascribed who had multiple intractable ulcers. She presented periodic fever abdominal pain. The genetic analysis showed...
A relationship between treatment outcomes and intestinal microbiota in patients with inflammatory bowel diseases has been demonstrated. Cyclosporine leads to rapid improvement severe ulcerative colitis. We hypothesized that the potent effects of cyclosporine would be exerted through relationships epithelial cells (IECs) host microbiota. The present study was designed elucidate on monocarboxylate transporter 1 (MCT1) regulation butyrate uptake by IECs. Colitis induced C57BL6 mice via...
The aim of this study was to assess the perioperative invasiveness endoscopic submucosal dissection for colorectal cancer quantitatively by using energy metabolism. In fifty-three patients who underwent cancer, resting expenditure an indirect calorimeter, body weight and basal Harris-Benedict equation before after dissection. Resting expenditure/body expenditure/basal were 19.7 ± 2.5 kcal/kg/day 0.96 0.12 on day dissection, whereas one they increased 21.0 2.9 1.00 0.13 (p<0.001 p<0.05,...
A 45-year-old Japanese male patient who was diagnosed with celiac disease (CeD) developed type I enteropathy-associated T-cell lymphoma (EATL). In 2013, the admitted to our hospital worsening of diarrhea and weight loss. Pathological examination biopsy specimens from duodenum ileum led a diagnosis suspected EATL. previous total colonoscopy (TCS) indicated villous atrophy in terminal ileum. The changed gluten-free diet, nutritional status gradually improved. September 2014, he experienced...
Evidence of small-bowel capsule endoscopy (SBCE) for evaluating lesions in Crohn's disease (CD) is lacking. We aimed to clarify the effectiveness and safety SBCE a large sample patients with CD.This multicenter prospective registration study recorded clinical information results definitive CD (d-CD) or suspected (s-CD). The primary outcomes were rates successful assessment activity using SBCE, diagnosis CD, adverse events. Secondary findings d-CD s-CD factors affecting incompletion...
Fever of unknown origin (FUO) is caused by various diseases, making differential diagnosis difficult. This study aimed to determine the clinical features patients with FUO for use in daily medical practice. Medical records who first visited our department between January 2008 and December 2017 were reviewed. We classified diagnostic categories as infection, non-infectious inflammation, neoplasm, others, unidentified through definitive compared characteristics fulfilled criteria classical...
This study aimed to elucidate whether changes in serum opsonic activity measured by lucigenin-dependent chemiluminescence and luminol-dependent are useful for estimating physical stress during the perioperative period of gastric endoscopic submucosal dissection. Serum peripheral blood 87 patients was examined morning day dissection, next day, at 4 days after Peak height area under curve were 106.1 ± 22.7% 102.0 24.7% on which increased significantly 113.6 29.4% 111.0 29.1% (both p<0.01),...
Endoscopic sub-mucosal dissection (ESD) is considered as a low-invasive treatment for early-stage colorectal cancer, but the degree of invasiveness has not been well investigated. The aim this study was to evaluate physical stress due ESD based on changes in serum opsonic activity (SOA). SOA examined by measuring reactive oxygen species (ROS) produced neutrophils using lucigenin-dependent chemiluminescence (LgCL) and luminol-dependent (LmCL). Sixty-nine patients were enrolled into morning...
Esophageal endoscopic submucosal dissection (ESD) is considered to be more complex than gastric ESD. This study aimed assess the physical invasiveness of esophageal ESD during perioperative periods by measuring resting energy expenditure (REE). The factors affecting REE that could used identify patients requiring management were also investigated. Overall, 75 who had undergone prospectively enrolled. REE, body weight, and basal measured on day following mean REE/body weight was 20.2...