A5031955905- Tryptophan and brain disorders
- Cholesterol and Lipid Metabolism
- Stress Responses and Cortisol
- Ion Channels and Receptors
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Neuroendocrine regulation and behavior
- Nuclear Receptors and Signaling
- Medicinal Plants and Neuroprotection
- Genetics and Neurodevelopmental Disorders
- Pharmacological Effects and Toxicity Studies
- Epilepsy research and treatment
- Neurogenesis and neuroplasticity mechanisms
- Epigenetics and DNA Methylation
- Biochemical Analysis and Sensing Techniques
Army Medical University
2021-2023
Valproic acid (VPA) exposure during pregnancy leads to a higher risk of autism spectrum disorder (ASD) susceptibility in offspring. Human dorsal forebrain organoids were used recapitulate course cortical neurogenesis the developing human brain. Combining morphological characterization with massive parallel RNA sequencing (RNA-seq) on analyze pathogenic effects caused by VPA and critical signaling pathway. We found that reduction size impairment proliferation expansion neural progenitor cells...
Epilepsy is a highly prevalent and drug-refractory neurological disorder characterized by spontaneous recurrent seizures. Estrogen identified to be proconvulsant lowers the seizure threshold of female epilepsy. receptor β (ERβ) has been proposed mediate neuroprotection in epilepsy, although underlying mechanism remains unknown.
Transient Receptor Potential Canonical 6 (TRPC6) has been suggested to be involved in synapse function and contribute hippocampal-dependent cognitive processes. Gene silencing of TRPC6 was performed by injecting adeno-associated virus (AAV) expressing TRPC6-specific shRNA (shRNA-TRPC6) into the hippocampal dentate gyrus (DG). Spatial learning, working memory social recognition were impaired shRNA-TRPC6 treated mice compared control after 4 weeks. In addition, gene ontology (GO) analysis...