A5100413708- Catalytic C–H Functionalization Methods
- Synthesis and Catalytic Reactions
- Catalytic Cross-Coupling Reactions
- Radical Photochemical Reactions
- EEG and Brain-Computer Interfaces
- MicroRNA in disease regulation
- Teleoperation and Haptic Systems
- Asymmetric Hydrogenation and Catalysis
- Robot Manipulation and Learning
- Cancer-related molecular mechanisms research
- Neuroscience and Neural Engineering
- Muscle activation and electromyography studies
- Prosthetics and Rehabilitation Robotics
- Robotics and Automated Systems
- High Entropy Alloys Studies
- Gaze Tracking and Assistive Technology
- Healthcare Technology and Patient Monitoring
- AI-based Problem Solving and Planning
- Effects of Vibration on Health
- Circular RNAs in diseases
- Robotic Locomotion and Control
- Additive Manufacturing Materials and Processes
- Soft Robotics and Applications
- Asymmetric Synthesis and Catalysis
- Pancreatic function and diabetes
Chinese Academy of Sciences
2012-2024
Fujian Institute of Research on the Structure of Matter
2018-2024
University of Chinese Academy of Sciences
2013-2024
Institute of Mechanics
2024
Beijing University of Technology
2023
Zhengzhou University of Light Industry
2016-2018
Shenyang Institute of Automation
2009-2016
Northeastern University
2015
Shanxi Medical University
2015
South China Agricultural University
2010-2013
Adipogenesis is tightly regulated by altering gene expression, and TNF-α a multifunctional cytokine that plays an important role in regulating lipogenesis. MicroRNAs are strong post-transcriptional regulators of cell differentiation. In our previous work, we found high expression miR-181a fat-rich pig breed. Using bioinformatic analysis, was identified as potential regulator TNF-α. Here, validated the target dual luciferase assay. response to adipogenesis, mimic or inhibitor used overexpress...
An efficient Rh/Cu-catalyzed method has been developed for the direct β-arylation or alkenylation of ketones using (hetero)aryl alkenyl carboxylic acids as coupling partners. This ketone β-functionalization reaction proceeded via merging Cu-catalyzed dehydrogenative desaturation and Rh-catalyzed carboxyl-directed C–H alkylation, exhibiting a broad substrate scope both TEMPO proved to be essential dehydrogenation process generation active Rh catalyst activation.
Hypothalamic gonadotropin-releasing hormone (GnRH) is a major regulator of follicle-stimulating (FSH) secretion in gonadotrope cell the anterior pituitary gland. microRNAs (miRNAs) are small RNA molecules that control gene expression by imperfect binding to 3′-untranslated region (3′-UTR) mRNA at post-transcriptional level. It has been proven miRNAs play an important role response and/or regulation. However, little known about regulation FSH secretion. In this study, primary cells were...
Simultaneous acquisition of brain activity signals from the sensorimotor area using NIRS combined with EEG, imagined hand clenching force and speed modulation activity, as well 6-class classification these motor parameters by NIRS-EEG were explored. Near infrared probes aligned C3 C4, EEG electrodes placed midway between probes. acquired six healthy subjects during tasks involving right hand. The results showed that is effective for simultaneously measuring area. study also in duration (0,...
A transition-metal-free oxidative formal [3 + 2 1] cycloaddition for the synthesis of symmetrical and unsymmetrical 2,4-disubstituted 1,3,5-triazines has been first demonstrated. The reaction is involved in a domino C–H amination alkyl ethers with amidines, C–O cleavage, nucleophilic addition, condensation, an aromatization process. Notably, two C–N bonds were constructed one pot, employed as novel carbon source 1,3,5-triazines. preliminary mechanistic studies revealed underwent radical pathway.
The decarboxylative alkynylation of (hetero)aryl carboxylic acids with terminal alkynes has been achieved by using a Pd(PPh3)4/PCy3 catalyst. This Pd-catalyzed method exhibits good functional group tolerance for both coupling partners and enables chemical modification complex molecules. establishment this reaction is attributed to the discovery highly selective bromination NBS (N-bromosuccinimide).
A copper-catalyzed oxidative formal [2+2+1+1] cycloaddition for the synthesis of symmetrical tetrasubstituted pyridines was first demonstrated. The reaction is involved in a domino cross-dehydrogenative coupling (CDC) β-keto esters and N-methylamides, C-N bond cleavage, Michael addition, condensation aromatization process. Multiple C-C bonds were constructed one pot via C-H cleavage which employed as carbon source pyridines. preliminary mechanistic studies revealed that C(sp3)-H...
An efficient approach for the direct synthesis of alkylated 4-hydroxycoumarin derivatives via a Cu-catalyzed cascade dehydrogenation/conjugate addition sequence starting from simple saturated ketones and 4-hydroxycoumarins has been developed. This protocol features excellent functional-group tolerance, easy scale-up, broad substrate scope including bioactive molecules. More importantly, series marketed drugs, such as warfarin, acenocoumarol, coumachlor, coumafuryl, can be obtained by this method.
We report that the direct oxidative cross-coupling of carbonyl compounds with simple alkenes is realized to synthesize α-allylated by identifying bisphosphine ligand BINAP enables copper catalyst integrate two different catalytic cycles in a one-pot system.
MicroRNAs (miRNAs) are an abundant class of small RNAs that regulate expressions most genes. miRNAs play important roles in the pituitary, "master" endocrine organ.However, we still don't know which role development pituitary tissue or how much they contribute to function. By applying a combination microarray analysis and Solexa sequencing, detected total 450 porcine pituitary. Verification with RT-PCR showed high degree confidence for obtained data. According current miRBase release17.0,...
Sperm-mediated gene transfer can be a very efficient method to produce transgenic pigs, however, the results from different laboratories had not been widely repeated. Genomic integration of transgene by injection pseudotyped lentivirus perivitelline space has proved reliable route generate animals. To test whether in delivered sperm, we studied incubation lentiviruses and sperm before insemination. After with pig spermatozoa, 62±3 lentiviral particles were detected per 100 cells using...
An iodine-mediated formal oxidative cycloaddition of amidines with tertiary amines was first demonstrated in air. Both symmetrical and unsymmetrical 2,4-disubstituted 1,3,5-triazines were obtained up to 85% yields. It is noted that a amine employed as one carbon synthon two C-N bonds formed pot. Control experiments revealed the reaction underwent radical pathway promoted by I+. The method transition-metal-free, peroxide-free, operationally simple implement wide scope substrates.
For Internet based real-time teleoperation systems, unknown and variable time delay can cause instability in the closed loop control system hence hinder task accomplishment. According to requirement of Internet-based teleoperation, exact prediction RTT improve greatly performance system. In this paper, statistical properties Round Trip Timedelay (RTT) are investigated we construct a sparse multivariate linear regressive (SMLR) model for processes on experimental results that indicate: 1)...
A Rh-catalyzed decarbonylative C–H coupling of in-situ-generated acid fluorides with amide substrates bearing ortho-Csp2–H bonds has been developed. This method enables alkyl, aryl, and alkenyl carboxylic acids to undergo (hetero)aromatic or amides in generally good yields via the situ conversion into also allows for functionalization a series structurally complex carboxyl-containing natural products pharmaceuticals as well pharmaceutical derivatives.
The dehydrogenation-triggered multiple C(sp
Microbiologically influenced corrosion (MIC) poses a threat to various fields, particularly in piping and cooling water systems. As green inhibitor, polyaspartic acid (PASP) faces challenges achieving the intended inhibition against MIC due biofilm. Therefore, mitigating biofilm might be key improving of PASP. D-Phenylalanine (D-Phe) was selected as an enhancer promote PASP on caused by Desulfovibrio vulgaris its potential role formation this work. The joint application D-Phe reduced rate...
We propose the architecture of a novel robot system merging biological and artificial intelligence based on neural controller connected to an external agent. initially built framework that dissociated network mobile implement realistic vehicle. The characterized by camera two-wheeled was designed execute target-searching task. modified software developed home-made stimulation generator build bi-directional connection between components via simple binomial coding/decoding schemes. In this...