A5100335400- Cell Adhesion Molecules Research
- Combustion and flame dynamics
- Advanced Combustion Engine Technologies
- Thermochemical Biomass Conversion Processes
- Single-cell and spatial transcriptomics
- Cancer-related molecular mechanisms research
- Mast cells and histamine
- Catalytic Processes in Materials Science
- Mesenchymal stem cell research
- Immune cells in cancer
- Erythrocyte Function and Pathophysiology
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Combustion and Detonation Processes
- Biodiesel Production and Applications
- Electrohydrodynamics and Fluid Dynamics
- Fire dynamics and safety research
- Cancer Genomics and Diagnostics
- Chemokine receptors and signaling
- Chromatin Remodeling and Cancer
- Heat transfer and supercritical fluids
- Vehicle emissions and performance
- Telomeres, Telomerase, and Senescence
- Fibroblast Growth Factor Research
- Biomarkers in Disease Mechanisms
- Long-Term Effects of COVID-19
Southern University of Science and Technology
2016-2024
Guiyang Medical University
2022
Novel (United States)
2020
Mayo Clinic
2020
Abstract Our recent studies demonstrate that the focal adhesion protein Kindlin-2 is critical for chondrogenesis and early skeletal development. Here, we show deleting from osteoblasts using 2.3-kb mouse Col1a1-Cre transgene minimally impacts bone mass in mice, but 10-kb Dmp1-Cre transgene, which targets osteocytes mature osteoblasts, results striking osteopenia mice. loss reduces osteoblastic population increases osteoclastic adipocytic populations microenvironment. upregulates sclerostin...
In vertebrates, the type 1 parathyroid hormone receptor (PTH1R) is a critical regulator of skeletal development and homeostasis; however, how it modulated incompletely understood. Here we report that deleting Kindlin-2 in osteoblastic cells using mouse 10-kb Dmp1-Cre largely neutralizes intermittent PTH-stimulated increasing bone volume fraction mineral density by impairing both osteoblast osteoclast formation murine adult bone. Single-cell profiling reveals loss increases proportion...
Cell-free DNA (cfDNA) in plasma has emerged as a potential important biomarker clinical diagnostics, particularly cancer. However, somatic mutations are also commonly found healthy individuals, which interfere with the effectiveness for cancer diagnostics. This study examined background white blood cells (WBC) and cfDNA controls based on sequencing data from 821 non-cancer individuals several samples aim of understanding patterns detected cfDNA. We determined mutation allele frequencies both...
The Hedgehog-regulated transcription factors GLI1 and GLI2 play overlapping roles in development disease; however, the mechanisms underlying their interplay remain elusive. We report for first time that physically functionally interact cancer cells. were shown to co-immunoprecipitate PANC1 pancreatic cells RMS13 rhabdomyosarcoma Mapping analysis demonstrated zinc finger domains of both proteins are required heteromerization. RNAi knockdown either or inhibited expression many...
Abstract Anti-PD-1 therapy has shown promising outcomes in the treatment of different types cancer. It is fundamental interest to analyze efficacy anti-PD-1 cancer patients infected with hepatitis B virus (HBV) since comorbidity HBV and widely documented. We designed a multicenter retrospective study evaluate on non-liver HBV. found achieved much better HBV+ than their HBV– counterparts. performed single-cell RNA sequencing (scRNA-seq) peripheral blood mononuclear cells (PBMCs) from...
Polyoxymethylene dimethyl ethers (PODEn, n = 1-8) as an oxygenated fuel are a promising alternative with high oxygen concentration, low C:H ratio, and no C-C bonds in their chemical structure. This could lead to smoke-free combustion. In this study, we chose focus on PODE1 because of its lower cetane number, which makes it more suitable for use spark ignition (SI) engines. However, boiling point octane number remain challenges. A may vapour pressure require storage handling comparable...
Chondrocyte is considered the only cell type in cartilage. However, heterogeneity of chondrocytes human articular cartilage still not well defined, which hinders our understanding pathogenesis osteoarthritis (OA). Here, we constructed a single-cell transcriptomic atlas healthy and identified nine chondrocyte subsets including homeostatic chondrocytes, proliferate fibrochondrocytes, hypertrophic (HTC). Interestingly, two distinct HTC subpopulations, among HTC-1 specifically expressed genes...
Abstract Insufficient pancreatic β-cell mass and reduced insulin expression are key events in the pathogenesis of diabetes mellitus (DM). Here we demonstrate high Talin-1 β-cells that deficiency reduces proliferation, which leads to expression, thus causing glucose intolerance without affecting peripheral sensitivity mice. High-fat diet fed exerbates these phenotypes. Mechanistically, interacts with E3 ligase smad ubiquitination regulatory factor 1 (Smurf1), prohibits signal transducer...
Impacts of blending fusel oil with gasoline on fuel combustion have been investigated experimentally in the current research to evaluate engine performance improvement and exhaust emission. Tested include F10, F20 (10% 20% by volume) pure as baseline used operate 4-cylinder SI at increasing speed constant throttle valve 45%. The present results reveal a shorter duration better F10 over speeds maximum value 33.9% for brake thermal efficiency. lowest BSFC 251 g/kW h was recorded 3500 rpm also...