A5083634448- Immune Cell Function and Interaction
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- MicroRNA in disease regulation
- Lung Cancer Research Studies
- Lung Cancer Treatments and Mutations
- Circular RNAs in diseases
- Autophagy in Disease and Therapy
- Genetic factors in colorectal cancer
- Immune cells in cancer
- Lung Cancer Diagnosis and Treatment
- Hepatitis B Virus Studies
- SARS-CoV-2 and COVID-19 Research
- Fuel Cells and Related Materials
- T-cell and B-cell Immunology
- Brain Metastases and Treatment
- Colorectal Cancer Treatments and Studies
- Galectins and Cancer Biology
- Epigenetics and DNA Methylation
- Pancreatic and Hepatic Oncology Research
- Renal Diseases and Glomerulopathies
- Caveolin-1 and cellular processes
- Sphingolipid Metabolism and Signaling
- Cellular transport and secretion
Taihe Hospital
2018-2025
Hubei University of Medicine
2018-2025
Southwest Hospital
2012-2024
Army Medical University
2013-2024
Guangxi Veterinary Research Institute
2023-2024
Ministry of Agriculture and Rural Affairs
2023-2024
Southern University of Science and Technology
2022
Guangdong Medical College
2013-2022
National Natural Science Foundation of China
2016
Eastern Cooperative Oncology Group
2016
Abstract Background: Long non-coding RNA (lncRNA) plays an important role in carcinoma progression and prognosis. However, little is known about the pathological of lncRNA Sox2ot colorectal cancer (CRC) patients. This study sought to investigate expression level CRC, as well explore its association with CRC Methods: LncRNA was measured 117 paired tissues adjacent non-cancerous using quantitative real-time polymerase chain reaction (qRT-PCR). Then, relationship between clinicopathological...
Abstract Metabolic reprogramming in stromal cells plays an essential role regulating tumour growth. The metabolic activities of tumour-associated macrophages (TAMs) colorectal cancer (CRC) are incompletely characterized. Here, we identify TAM-derived factors and their roles the development CRC. We demonstrate that ABHD5, a lipolytic co-activator, is ectopically expressed CRC-associated macrophages. vitro mouse models macrophage ABHD5 potentiates growth CRC cells. Mechanistically, suppresses...
Abstract The biomechanics stress and chronic inflammation in obesity are causally linked to osteoarthritis. However, the metabolic factors mediating obesity-related osteoarthritis still obscure. Here we scanned identified at least two elevated metabolites (stearic acid lactate) from plasma of diet-induced obese mice. We found that stearic potentiated LDH-a-dependent production lactate, which further stabilized HIF1α protein increased VEGF proinflammatory cytokine expression primary mouse...
Cellular senescence is an important tumor-suppressive mechanism. However, acquisition of a senescence-associated secretory phenotype (SASP) in senescent cells has deleterious effects on the tissue microenvironment and, paradoxically, promotes tumor progression. In drug screen, we identified melatonin as novel SASP suppressor human cells. Strikingly, blunts global gene expression upon oncogene-induced (OIS). Moreover, poly(ADP-ribose) polymerase-1 (PARP-1), sensor DNA damage, was new...
Cancer is typically considered as a genetic and epigenetic disease. Although numerous studies have indicated that an aberrant structure, function, or expression level of enzymes contribute to many tumor types, precisely how the mechanisms are involved in hepatitis B virus (HBV)-induced hepatocellular carcinoma (HCC) remains unknown.In this study, we found WD repeat domain 5 protein (WDR5)-a core subunit histone H3 lysine 4 methyltransferase complexes, which catalyze generation trimethylation...
Numerous evidences indicated that angiogenesis was a crucial step in the development of tumor, thus immunotherapy antiangiogenesis has been involved as potentially relevant candidate targets cancer immunotherapy. Recently, tumor endothelial marker 8 (TEM8) discovered to be dominantly expressed endothelium, which presented new strategy therapy. However, up date, related study TEM8 on is very few. In this study, we constructed xenogenic DNA vaccine encoding human carried by attenuated...
H5, H7 and H9 are the most important subtypes of avian influenza viruses (AIVs), nine neuraminidase (NA) (N1-N9) AIVs have been identified in poultry. A method that can simultaneously detect H7, NA would save time effort. In this study, 13 pairs primers, including 12 subtype-specific primers for detecting particular (H5, N1-N9) one pair universal all AIVs, were designed screened. The mixed same reaction, target genes detected. GeXP assay using to was developed. showed specific binding...
Recent studies indicate that propofol may protect cells via suppressing autophagic cell death caused by excessive reactive oxygen species induced hypoxia reoxygenation (H/R). It is established gene expression patterns including autophagy-related genes changed significantly during the process of H/R in presence or absence posthypoxia treatment (P-PostH). The reasons for such differences, however, remain largely unknown. MicroRNAs provide a novel mechanism regulation. In present study, we...
This study aimed to investigate whether single nucleotide polymorphisms (SNPs) in the promoter of excision repair cross complementation group 5 (ERCC5) gene influences response oxaliplatin-based chemotherapy. Eighty-three patients with cytologically or histologically confirmed advanced colorectal cancer (CRC), at least one measurable lesion and underwent chemotherapy were studied. To this end, six (-1415C>T, -763A>G, -413C>T, +25A>G, +202C>T, +372C>T) ERCC5 selected for investigation....
Central nervous system (CNS) brain metastasis of advanced non-small cell lung cancer (NSCLC) patients confers a worse quality life and prognosis. The efficacy comparison two first-generation epidermal growth factor receptor (EGFR) inhibitors erlotinib or gefitinib as first-line treatment for CNS NSCLC with EGFR-sensitizing mutations is yet to be elucidated.A retrospective analysis was done on cerebral rate after mutations. Time neurological progression (nTTP) median progression-free survival...
Programmed death-1 (PD-1), a key immune checkpoint molecule, has been developed as an oncotherapy target for various carcinomas. However, treatment with anti-PD-1 elicited only minimal effect in pancreatic ductal adenocarcinoma (PDAC). Subsequent studies revealed the existence of subset PD-1+ T cells coexpressing CD38 and CD101, representing fixed dysfunctional subpopulation that are not able to be rescued by immunotherapy. whether this PD-1 expressing CD8+ could useful predicting PDAC stage...
Abstract Objective It has been demonstrated that signals from the inhibitory receptor B and T lymphocyte attenuator (BTLA) are involved in regulating pathogenesis of infectious diseases. However, expression anatomical distribution BTLA its ligand, herpes virus entry mediator (HVEM), have not yet determined cases HBV-related acute-on-chronic liver failure (HBV-ACLF) patients. Methods In this study, HVEM tissues HBV-ACLF, chronic hepatitis (CHB) patients healthy individuals was analyzed by...
INPP4B (Inositol polyphosphate 4-phosphatase type II) has been regarded as a suppressor of several human tumors, but its biological function, expression, and clinical significance in glioma tissues cell lines are unclear. Notably, whether participates immune escape deserves urgent attention. Here, we confirmed that expression is often downregulated low- high-grade tissues, from an orthotopic mouse model brain cells. We found overexpression restrained the proliferation, migration, apoptosis...
Abstract Background The spike (S) protein is a major structural glycoprotein of coronavirus (CoV), the causal agent severe acute respiratory syndrome (SARS). S potent target for SARS-specific cell-mediated immune responses. However, mechanism CoV pathogenesis in SARS and role special CTLs virus clearance are still largely uncharacterized. Here, we describe study that leads to identification novel HLA-A*0201-restricted epitope from conserved regions protein. Results First, different SARS-CoV...