A5017617784- Animal Virus Infections Studies
- Animal Disease Management and Epidemiology
- Viral gastroenteritis research and epidemiology
- Influenza Virus Research Studies
- Virus-based gene therapy research
- Viral Infections and Immunology Research
- Aquaculture disease management and microbiota
- Respiratory viral infections research
- Identification and Quantification in Food
- Virology and Viral Diseases
- Viral Infections and Vectors
- Microbial infections and disease research
- Herpesvirus Infections and Treatments
- Plant Virus Research Studies
- Bacteriophages and microbial interactions
- Viral Infectious Diseases and Gene Expression in Insects
- Advanced biosensing and bioanalysis techniques
- Genomics and Phylogenetic Studies
- interferon and immune responses
- Biosensors and Analytical Detection
- Genetic diversity and population structure
- Vector-Borne Animal Diseases
- Vibrio bacteria research studies
- Invertebrate Immune Response Mechanisms
- Aquaculture Nutrition and Growth
Guangxi Veterinary Research Institute
2015-2024
Ministry of Agriculture and Rural Affairs
2022-2024
Hefei University of Technology
2024
Guangxi Academy of Agricultural Science
2019
Nanning Normal University
2018
Princess Margaret Cancer Centre
2017
University Health Network
2017
University of Toronto
2017
Central China Normal University
2016
Feminist Archive North
2012
Infectious bronchitis virus (IBV) is a positive-sense, single-stranded, enveloped RNA responsible for substantial economic losses to the poultry industry worldwide by causing highly contagious respiratory disease. The can spread quickly through contact, contaminated equipment, aerosols, and personal-to-person contact. We highlight prevalence geographic distribution of all nine genotypes, as well relevant symptoms impact, extensively analyzing current literature. Moreover, phylogenetic...
Low pathogenic avian influenza virus (LPAIV) usually causes mild disease or asymptomatic infection in poultry. However, some LPAIV strains can be transmitted to humans and cause severe infection. Genetic rearrangement recombination of even low may generate a novel with increased virulence, posing substantial risk public health. Southern China is regarded as the world "influenza epicenter", due rash outbreaks recent years. In this study, we conducted an epidemiological survey at different...
Despite the heterogeneity of acute myeloid leukemia (AML), overexpression interleukin-3 receptor-α (CD123) on both more differentiated leukemic blast and stem cells (LSCs) provides a therapeutic target for antibody treatment. Here we present data potential clinical activity monoclonal CSL362, which binds to CD123 with high affinity. We first validated expression by 100% (52/52) patient samples correlation NPM1 FLT3-ITD mutations frequency in AML. In vitro studies demonstrated that CSL362...
Abstract An electrochemical immunoassay for the ultrasensitive detection of Newcastle disease virus (NDV) was developed using graphene and chitosan-conjugated Cu(I)/Cu(II) (Cu(I)/Cu(II)-Chi-Gra) signal amplification. Graphene (Gra) used both conjugation an anti-Newcastle monoclonal antibody (MAb/NDV) immobilization polyclonal antibodies (PAb/NDV). selected as electroactive probe, immobilized on a chitosan-graphene (Chi-Gra) hybrid material, detected by differential pulse voltammetry (DPV)...
Influenza A viruses (IAVs) evade the immune system of host by several regulatory mechanisms. Their genomes consist eight single-stranded segments, including nonstructural proteins (NS), basic polymerase 1 (PB1), 2 (PB2), hemagglutinin (HA), acidic (PA), matrix (M), neuraminidase (NA), and nucleoprotein (NP). Some these are known to suppress responses. In this review, we discuss roles, functions underlying strategies adopted IAV escape targeting different in interferon (IFN) signaling...
H5, H7 and H9 are the most important subtypes of avian influenza viruses (AIVs), nine neuraminidase (NA) (N1-N9) AIVs have been identified in poultry. A method that can simultaneously detect H7, NA would save time effort. In this study, 13 pairs primers, including 12 subtype-specific primers for detecting particular (H5, N1-N9) one pair universal all AIVs, were designed screened. The mixed same reaction, target genes detected. GeXP assay using to was developed. showed specific binding...
Fowl adenovirus serotype 4 (FAdV-4) is highly pathogenic to broilers aged 3 5 weeks and has caused considerable economic loss in the poultry industry worldwide. FAdV-4 causative agent of hydropericardium-hepatitis syndrome (HHS) or hydropericardium (HPS). The virus targets mainly liver, HPS symptoms are observed infected chickens. This disease was first reported Pakistan but now spread worldwide, over time, various deletions FAdV genome mutations its major structural proteins have been...
We report a novel electrochemical immunosensor that can sensitively detect avian influenza virus H5 subtype (AIV H5) captured by graphene oxide-H5-polychonal antibodies-bovine serum albumin (GO-PAb-BSA) nanocomposite. The oxide (GO) carried H5-polychonal antibody (PAb) were used as signal amplification materials. Upon amplification, the showed 256-fold increase in detection sensitivity compared to without GO-PAb-BSA. designed PAb labeling GO strategy and procedure allow ultrasensitive...
Abstract Background Recent epidemiological investigation of different HA subtypes avian influenza viruses (AIVs) shows that the H3 subtype is most predominant among low pathogenic AIVs (LPAIVs), and seasonal variations in isolation are consistent with human viruses. Consequently, development a rapid, simple, sensitive detection method for required. The loop-mediated isothermal amplification (LAMP) assay cost-effective nucleic acid does not require any specialized equipment. Results A reverse...
Infections with low pathogenic avian influenza viruses (LPAIVs) can be mild or asymptomatic in poultry; however, humans, LPAIVs cause severe infections and death, as demonstrated by the H7N9 H10N8 human infection outbreaks 2013 China. In this study, we conducted an epidemiological survey of at live poultry markets (LPMs) Guangxi Province, Southern China, which is near several Southeast Asian countries. From January 2012 to December 2015, collected 3,813 swab samples from LPMs Guangxi. Viral...
Chicken parvovirus (ChPV), chicken infectious anaemia virus (CIAV) and fowl adenovirus serotype 4 (FAdV-4) are avian viruses that have emerged in recent years endangered the global poultry industry, causing great economic loss. In this study, a multiplex fluorescence-based loop-mediated isothermal amplification (mLAMP) assay for detecting ChPV, CIAV FAdV-4 was developed to simultaneously diagnose single mixed infections chickens. Three primer sets composite probes were designed according...
Interferon-inducible transmembrane protein 3 (IFITM3) is an antiviral factor that plays important role in the host innate immune response against viruses. Previous studies have shown IFITM3 upregulated various tissues and organs after avian reovirus (ARV) infection, which suggests may be involved ARV infection. In this study, chicken gene was cloned analyzed bioinformatically. Then, of infection further explored. The results showed molecular weight approximately 13 kDa. This found to...
The H10 subtype avian influenza viruses (H10N4, H10N5 and H10N7) have been reported to cause disease in mammals, the first human case of H10N8 virus was 2013. Recently, (AIVs) followed more closely, but routine diagnostic tests are tedious, less sensitive time consuming, rapid molecular detection assays for AIVs not available. Based on conserved sequences within HA gene AIVs, specific primer sets were designed assay reaction conditions optimized. A reverse-transcription loop-mediated...
Duck circovirus (DuCV) infection in farmed ducks is associated with growth problems or retardation syndromes. Rapid identification of DuCV infected essential to control effectively. Therefore, this study aims develop an assay for be highly specific, sensitive, and simple without any specialized equipment. A set six specific primers was designed target the sequences Rep gene DuCV, loop-mediated isothermal amplification (LAMP) were developed reaction conditions optimized rapid detection DuCV....
Immunosuppressive viruses are frequently found as co-infections in the chicken industry, potentially causing serious economic losses. Because traditional molecular biology methods have limited detection ability, a rapid, high-throughput method for differential diagnosis of these is needed. The objective this study to develop GenomeLab Gene Expression Profiler Analyser-based multiplex PCR (GeXP-multiplex PCR) simultaneous eight immunosuppressive viruses. Using chimeric primers, such viruses,...