A5103072214- Immunotherapy and Immune Responses
- Advanced Algorithms and Applications
- Glycosylation and Glycoproteins Research
- Advanced Sensor and Control Systems
- Medical Research and Treatments
- Underwater Vehicles and Communication Systems
- Water Quality Monitoring Technologies
- Gastrointestinal motility and disorders
- Pharmacological Effects of Natural Compounds
- Immune Cell Function and Interaction
- Traditional Chinese Medicine Studies
- T-cell and B-cell Immunology
- RNA Interference and Gene Delivery
- Image Enhancement Techniques
- Eosinophilic Esophagitis
- Medical Image Segmentation Techniques
- Cancer-related Molecular Pathways
- Proteoglycans and glycosaminoglycans research
- vaccines and immunoinformatics approaches
- Gastroesophageal reflux and treatments
- Helicobacter pylori-related gastroenterology studies
- Retinoids in leukemia and cellular processes
- Lipid metabolism and disorders
- Burn Injury Management and Outcomes
- Advanced Image and Video Retrieval Techniques
Chinese Academy of Medical Sciences & Peking Union Medical College
2010-2025
Xiyuan Hospital
2025
Southwest Hospital
2007-2024
Army Medical University
2007-2024
Institute of Modern Physics
2023
Chinese Academy of Sciences
2023
Zhongshan Hospital
2023
Fudan University
2023
China West Normal University
2023
East China Normal University
2020-2022
Human telomerase reverse transcriptase (hTERT) has been found to be closely related tumor transformation, growth, and metastasis. Thus, the delivery of hTERT small interfering RNA (siRNA) is an important approach for cancer gene therapy. However, single anticancer effect silencing often limited by poor specificity or low efficiency in siRNA release. In this work, we present thin black phosphorus (BP) nanosheets as a biodegradable system siRNA. The BP prepared with poly(ethylene glycol) (PEG)...
The B7 family ligand HERV-H LTR-associating protein 2 (HHLA2) is an attractive target for cancer immunotherapy because of its coinhibitory function, overexpression in human cancers, and association with poor prognoses. However, the knowledge HHLA2 pathway incomplete. has established positive receptor transmembrane immunoglobulin (Ig) domain containing (TMIGD2) but a poorly characterized negative killer cell Ig-like receptor, three Ig domains, long cytoplasmic tail (KIR3DL3). Here, KIR3DL3...
The PD-1/PD-L1 pathway in mucosal immunity is currently actively explored and considered as a target for inflammatory bowel disease (IBD) treatment. However, systemic PD-L1 administration may cause unpredictable adverse effects due to immunosuppression. Here we show that reactive oxygen species (ROS)-responsive nanoparticles enhance the efficacy safety of mouse colitis model. control accumulation release fused Fc (PD-L1-Fc) at sites colon. nanotherapeutics shows superiority alleviating...
Cellular senescence is an important tumor-suppressive mechanism. However, acquisition of a senescence-associated secretory phenotype (SASP) in senescent cells has deleterious effects on the tissue microenvironment and, paradoxically, promotes tumor progression. In drug screen, we identified melatonin as novel SASP suppressor human cells. Strikingly, blunts global gene expression upon oncogene-induced (OIS). Moreover, poly(ADP-ribose) polymerase-1 (PARP-1), sensor DNA damage, was new...
Activation of the inflammatory transcription factor NF-κB in tumor-associated macrophages (TAMs) is assumed to contribute tumor promotion. However, whether and how drives antitumor become pro-tumorigenic have not been determined any cancer type yet. Similarly, TAMs repress CD8+ cytotoxic T lymphocytes (CTLs) remains largely unknown, although their importance regulatory (Treg) cell regulation promotion has well appreciated. Here, using an endogenous lung model we uncover a direct crosstalk...
Abstract Background HHLA2 is a recently discovered member of the B7-family immune checkpoint molecules with limited expression in normal tissues but overexpression several types cancer. The aim was to determine expression, prevalence and biological relevance protein two closely related human cancer types, namely pancreatic ampullary Methods levels were retrospectively determined by immunohistochemistry tissue micro-arrays surgically resected tumours 122 patients 72 pancreato-biliary subtype....
Neutrophil-to-lymphocyte ratio (NLR) is a marker of inflammation. This study aimed to evaluate the potential role NLR predict 90-day mortality.Data 577 patients with burns over 30% total body surface area were collected and retrospectively analyzed. The risk factors for mortality evaluated using logistic regression analyses. Receiver operating characteristic (ROC) curve analysis 3rd day was performed optimal cut-off value calculated. rates compared between high low groups Kaplan-Meier...
Rifampin (RFP), a first-line anti-tuberculosis drug, often induces cholestatic liver injury and hyperbilirubinemia which limits its clinical use. Multidrug resistance-associated protein 2 (MRP2) localizes to the hepatocyte apical membrane plays pivotal role in biliary excretion of bilirubin glucuronides. RFP is discovered reduce MRP2 expression cells. 4-Phenylbutyrate (4-PBA), drug used treat ornithine transcarbamylase deficiency (DILI), reported alleviate RFP-induced cell injury. However,...
Peptide vaccination for cancer immunotherapy requires identification of peptide epitopes derived from antigenic proteins associated with tumors. Heparanase (Hpa) is broadly expressed in various advanced tumors and seems to be an attractive new tumor-associated antigen. The present study was designed predict identify HLA-A2– restricted cytotoxic T lymphocyte (CTL) the protein human Hpa. For this purpose, HLA-A2–restricted CTL were identified using following four-step procedure: 1) a...
Peptide vaccination for cancer immunotherapy requires an ideal immune response induced by epitope peptides derived from tumor-associated antigens (TAA). Heparanase is broadly expressed in various advanced tumors. Accumulating evidence suggests that heparanase can serve as a universal TAA tumor immunotherapy. However, due to the low immunogenicity of peptide vaccines, against tumors usually cannot be elicited patients. To increase we designed three 4-branched multiple antigenic (MAP) on basis...
Abstract The identification of CTL epitopes from tumor antigens is very important for the development peptide-based, cancer-specific immunotherapy. Heparanase broadly expressed in various advanced tumors and can serve as a universal tumor-associated antigen. Although several heparanase antigen are known humans, corresponding knowledge mice still rather limited. present study was designed to predict identify mouse protein. For this purpose, H-2Kb–restricted were identified by using following...
Background and Aims: Dendritic cell-based tumor vaccination is a promising approach in the treatment of cancer. Strategies to modify dendritic cells (DCs) with tumor-associated antigens (TAAs) can elicit specific immune responses against tumors. Heparanase overexpressed gastric cancer, especially invasive metastatic cells, but downregulated differential normal tissue. Therefore, heparanase potential target immunotherapy for patients advanced cancer who are not candidates surgery. The present...
Accumulating research suggests that heparanase may be a universal tumor-associated antigen (TAA). Several T-cell epitopes from humans and mice have already been identified. However, because of low immunogenicity, polypeptide vaccines usually difficulty inducing effective antitumor immune responses in vivo. In this study, to increase the immunogenicity vaccines, we designed synthesized two four-branch multiple antigenic peptides (MAP) on basis mouse (mHpa) (mHpa398 mHpa519). The dendritic...
Anaplastic lymphoma kinase (ALK) has been described in a range of human cancers and is involved cancer initiation progression via activating multiple signaling pathways, such as the PI3K-AKT, CRKL-C3G, MEKK2/3-MEK5-ERK5, JAK-STAT MAPK signal pathways.Recently ALK LTK ligand 1 (ALKAL1) also named "augmentor-β" or "FAM150A" identified potent ligands for that bind to extracellular domain ALK.However, due its poor stability, mechanisms ALKAL1 underlying tumor including colorectal have not well...
// Tie-qiu Yin 1 , Xuan Ou-yang Fang-yan Jiao Lu-ping Huang Xu-dong Tang Bi-qiong Ren The Second People’s Hospital of Hunan Province, Clinical Medical College University Chinese Medicine, Changsha 410007, China Correspondence to: Yin, email: ytqstar@163.com Keywords: cervical cancer, PA-MSHA, PTEN, p-AKT, p-GSK3β Received: September 30, 2015 Accepted: April 24, 2016 Published: May 19, 2016 ABSTRACT We investigated the...
We investigate the effects of non-Gaussian colored noise on a calcium oscillation system using stochastic simulation methods. It is found that reciprocal coefficient variance R has maximum (Rmax) with increasing intensity Q. The parameter q an important effect system. For some values (e.g., = 0.9, 1.0), correlation time τ. Non-Gaussian induced spikes are more regular than Gaussian when small and Q large values. q. Therefore, could play effective roles in