A5102715190- Circular RNAs in diseases
- RNA modifications and cancer
- MicroRNA in disease regulation
- Cancer-related gene regulation
- Autophagy in Disease and Therapy
- Quantum Information and Cryptography
- Cancer-related molecular mechanisms research
- interferon and immune responses
- Cancer Genomics and Diagnostics
- Kruppel-like factors research
- Esophageal Cancer Research and Treatment
- Axon Guidance and Neuronal Signaling
- Bladder and Urothelial Cancer Treatments
- Trauma and Emergency Care Studies
- Pediatric health and respiratory diseases
- Quantum Computing Algorithms and Architecture
- Hepatitis C virus research
- Wnt/β-catenin signaling in development and cancer
- Cancer Immunotherapy and Biomarkers
- Quantum and electron transport phenomena
- Burn Injury Management and Outcomes
- Endoplasmic Reticulum Stress and Disease
- Quantum optics and atomic interactions
- Down syndrome and intellectual disability research
- Mechanical and Optical Resonators
Moffitt Cancer Center
2025
Shangrao Normal University
2023-2024
Shandong First Medical University
2021-2022
Shandong Tumor Hospital
2021-2022
First Affiliated Hospital of Anhui Medical University
2013-2021
Anhui Medical University
2013-2021
Academy of Medical Sciences
2021
Ningbo No.6 Hospital
2016-2017
Jiangxi Agricultural University
2016
863 Background: We previously reported that the combination of IPI-NIVO plus SG shows high efficacy with 83.3% objective response rate (ORR) and durable responses as first-line treatment for cisplatin-ineligible mUC patients in a Phase I/II trial. However, two grade 5 immune-mediated myocarditis events attributed to occurred, leading early trial termination after accruing 25 patients. Given ORR, we performed correlative analysis identify predictive biomarker response. Methods: For Nanostring...
Long non-coding RNAs (lncRNAs) play an important role in cancer occurrence and development. We previously demonstrated that lncRNA gastric cancer-associated transcript 3 (GACAT3) was positively correlated with TNM stages, tumor size, distant metastasis of patients cancer. However, the GACAT3 remains unclear. In this study, to investigate its function, we synthesized small interference (siRNAs) against GACTA3 developed a overexpression vector (pcDNA3-GACAT3), respectively. The siRNA-mediated...
Neutrophil-to-lymphocyte ratio (NLR) is a marker of inflammation. This study aimed to evaluate the potential role NLR predict 90-day mortality.Data 577 patients with burns over 30% total body surface area were collected and retrospectively analyzed. The risk factors for mortality evaluated using logistic regression analyses. Receiver operating characteristic (ROC) curve analysis 3rd day was performed optimal cut-off value calculated. rates compared between high low groups Kaplan-Meier...
Microwave-optical interactions and hybrid entangled states are crucial for building quantum networks. In this work, we propose an approach realizing a cross-Kerr nonlinear interaction between microwave optical cavities using ensemble of nitrogen-vacancy centers (NV ensemble). This is achieved by NV dispersively coupled to cavity cavity. As application, show that the can be used create state discrete-variable (DV) qubit continuous-variable (CV) qubit. The DV here refers qubit, with two logic...
The Toffoli gate is a three-qubit controlled-controlled-NOT gate, which plays central role in quantum information processing and computing. Recently, hybrid systems gates have attracted much attention. We propose an efficient scheme to implement with two nitrogen-vacancy center ensembles (NV ensembles) as the control qubits single superconducting flux qubit target qubit. This realized by employing NV coupled qutrit. constructed controlled-controlled-phase (CCPHASE) sandwiched between...
Presbycusis affects approximately one-third of people over the age 65 and is a worldwide health problem. In current study, whether methylation level solute carrier family 26 member 4 (SLC26A4) predicted an increased risk presbycusis was investigated. Peripheral blood samples from 102 patients with 104 controls were collected, CpG sites SLC26A4 measured by applying pyrosequencing technology combined sodium bisulfate DNA conversion chemistry. Within promoter region, one site (CpG3) exhibited...
Abstract: Glioma is one of the most common types adult primary brain tumors, and underlying molecular mechanisms still remain unclear. Nuclear factor-kappa B1 (NF-κB1) involved in a variety malignancies widely expressed malignant tumors. However, expression NF-κB1 different grades glioma, correlation between Bcl-2 expressions gliomas, research early apoptosis glioma cells have not been reported so far. In this study, level 31 human tissues six nonneoplastic was determined using quantitative...
The aim of this study was to draw a comprehensive mutational landscape nasopharyngeal carcinoma (NPC) tumors and identify the prognostic factors for distant metastasis-free survival (DMFS).A total forty primary nonkeratinizing NPC patients underwent targeted next-generation sequencing 450 cancer-relevant genes. Analysis these clinical data performed comprehensively. Univariate Cox regression analysis multivariate Lasso-Cox analyses were that predict metastasis construct risk score model,...
Abstract miR-30c functions as a tumor suppressor gene in the majority of tumors, including gliomas. In our study, we discovered that expression levels glioma tissues and plasma prior to surgery were lower than those normal brain tissue following injury decompression healthy volunteers. The low was closely aligned with WHO grade, size, PFS, OS. Additionally, level positively correlated preoperative plasma. cell biology experiments, inhibited EMT proliferation, migration, invasion cells....
Abstract miR-30c functions as a tumor suppressor gene in the majority of tumors, including glioma. In our study, we discovered that expression levels glioma tissues and plasma prior to operation were lower than normal brain tissue following injury decompression healthy volunteers. The low was closely aligned with WHO grade, size, PFS, OS. Additionally, level positively correlated found preoperative plasma. cell biology experiments, inhibit EMT, proliferation, migration, invasion cells....
Background: Pancreatic cancer remains one of the most lethal human malignancies worldwide. However, molecular mechanisms underlying have not been fully understood. The roles Collapsin Response Mediator Protein 1 (CRMP1), which is an intracellular mediator semaphorin signal pathway in pancreatic largely unknown.Methods: Bioinformatics analysis, immunohistochemistry, real-time qRT-PCR were used to study expression CRMP1. Xenograft model, cell growth, migration, and invasion assays performed...