A5051516231- Cancer Immunotherapy and Biomarkers
- Cancer Treatment and Pharmacology
- Estrogen and related hormone effects
- Breast Cancer Treatment Studies
- Advanced Breast Cancer Therapies
- Immunotherapy and Immune Responses
- Pancreatic and Hepatic Oncology Research
- Venous Thromboembolism Diagnosis and Management
- HER2/EGFR in Cancer Research
- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- Cancer Diagnosis and Treatment
- Hormonal and reproductive studies
- Brain Metastases and Treatment
- Colorectal Cancer Treatments and Studies
- Immune Cell Function and Interaction
- Thyroid Cancer Diagnosis and Treatment
- Wnt/β-catenin signaling in development and cancer
- Hepatocellular Carcinoma Treatment and Prognosis
- Renal cell carcinoma treatment
- Galectins and Cancer Biology
- Inflammatory Biomarkers in Disease Prognosis
- interferon and immune responses
- Cancer therapeutics and mechanisms
- Pharmacogenetics and Drug Metabolism
Mayo Clinic in Florida
2010-2025
Jacksonville College
2022-2025
WinnMed
2021-2025
Nemours Children's Clinic
2023-2024
Mayo Clinic in Arizona
2004-2023
Erasmus MC
2013-2022
Nemours Children’s Clinic
2021
Erasmus University Rotterdam
2016-2020
Rotterdam University of Applied Sciences
2020
Mayo Clinic
2004-2017
Objective: Our aim was to determine the prognostic significance of systemic-immune-inflammation index (SIII) in patients with resectable pancreatic cancer, using cancer-specific survival as primary outcome. Background: Pancreatic cancer is associated a dysfunctional immune system and poor prognosis. We examined SIII ductal adenocarcinoma (PDAC) effects bilirubin on this index. Methods: retrospectively assessed all resections performed between 2004 2015 at 4 tertiary referral centers identify...
Novel systemic treatments for hepatocellular carcinoma (HCC) are strongly needed. Immunotherapy is a promising strategy that can induce specific antitumor immune responses. Understanding the mechanisms of resistance by HCC crucial development suitable immunotherapeutics. We used immunohistochemistry on tissue-microarrays to examine co-expression inhibiting molecules PD-L1, Galectin-9, HVEM and IDO, as well tumor CD8+ lymphocyte infiltration in HCC, two independent cohorts patients. found at...
Pazopanib is a small molecule inhibitor of kinases principally including vascular endothelial growth factor receptors-1, -2, and -3; platelet-derived receptors-α -β; c-Kit. We previously reported tumor response rate 49% in patients with advanced differentiated thyroid cancer 0% anaplastic cancer. The present report details results pazopanib therapy medullary (MTC). OBJECTIVE, DESIGN, SETTING, PATIENTS, INTERVENTION, AND OUTCOME MEASURES: Having noted preclinical activity MTC, MTC who had...
Abstract Purpose: The aim of PREDICT was to confirm clinical validity and the potential for utility serial circulating tumor cell (CTC) enumeration in metastatic breast cancer (MBC) patients focusing on its prognostic value different subtypes settings. Experimental design: In total, 4436 individual patient-level data with CTC results from both baseline one follow-up (CellSearch®; Menarini Silicon Biosystems) were analyzed evaluate association between detection overall survival (OS) full...
Epigenetic modifiers, including the histone deacetylase inhibitor vorinostat, may sensitize tumors to chemotherapy and enhance outcomes. We conducted a multicenter randomized phase II neoadjuvant trial of carboplatin nanoparticle albumin-bound paclitaxel (CP) with vorinostat or placebo in women stage II/III, human epidermal growth factor receptor 2 (HER2)–negative breast cancer, which we also examined whether change maximum standardized uptake values corrected for lean body mass (SULmax) on...
Understanding the mechanisms of immune resistance in pancreatic and ampullary cancers is crucial for development suitable biomarkers effective immunotherapeutics. Our aim was to examine expression inhibiting molecules PD-L1, Galectin-9, HVEM, IDO HLA-G, as well CD8+ FoxP3+ tumor infiltrating lymphocytes (TIL), cancers, relate their individual, combined expression, cancer survival. Tumor tissue from 224 patients with resected (n = 148) 76) used construct tissue-microarrays. Expression...
Background and Objectives Patients with isolated colorectal‐cancer‐liver‐metastases (CRCLM) frequently undergo metastatectomy. Tumor‐infiltrating‐lymphocytes (TILs) have prognostic potential in the setting of primary colorectal cancer, however, their role CRCLM is less studied. We aimed to study spatial distribution tumor‐infiltrating CD8 + cytotoxic T‐cells FoxP3 regulatory at metastatic site patients. Methods TILs were from fresh tissues 47 patients CRCLM. Archived paraffin‐embedded...
Abstract Tumor expression of immune co-inhibitory ligands, such as PD-L1 and Galectin-9, have potential prognostic value in Hepatocellular Carcinoma (HCC). Circulating levels these molecules, however, hardly been studied. This study aims to assess the significance circulating Galectin-9 patients with resected HCC, compare their intra-tumoral same molecules. Archived tissues stored peripheral blood samples from 81 who underwent HCC resection or liver transplantation, curative intent, were...
Abstract Background Patients with resected colorectal liver metastasis (CRLM) who display only the desmoplastic histopathological growth pattern (dHGP) exhibit superior survival compared to patients any non-desmoplastic (non-dHGP). The aim of this study was compare tumour microenvironment between dHGP and non-dHGP. Methods investigated in three cohorts chemo-naive surgically treated for CRLM. In cohort A semi-quantitative immunohistochemistry performed, B intratumoural peritumoural T cells...
Only 10% of pancreatic ductal adenocarcinoma (PDAC) patients survive longer than five years. Factors underlining long-term survivorship in PDAC are not well understood. Therefore, we aimed to identify the key players tumor immune microenvironment (TIME) associated with patients. The immune-related gene expression profiles resected tumors who survived and remained recurrence-free disease for ≥36 months (long-term survivors, n=10) were compared had ≤6 (short-term due recurrence. Validation was...
Identification of tumour antigens is crucial for the development vaccination strategies against hepatocellular carcinoma (HCC). Most studies come from eastern-Asia, where hepatitis-B main cause HCC. However, antigen expression poorly studied in low-endemic, western areas aetiology HCC differs. We constructed tissue microarrays resected 133 patients. Expression a comprehensive panel cancer-testis (MAGE-A1, MAGE-A3/4, MAGE-A10, MAGE-C1, MAGE-C2, NY-ESO-1, SSX-2, sperm protein 17), onco-fetal...
Abstract Background HHLA2 is a recently discovered member of the B7-family immune checkpoint molecules with limited expression in normal tissues but overexpression several types cancer. The aim was to determine expression, prevalence and biological relevance protein two closely related human cancer types, namely pancreatic ampullary Methods levels were retrospectively determined by immunohistochemistry tissue micro-arrays surgically resected tumours 122 patients 72 pancreato-biliary subtype....