A5041476280- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- Breast Cancer Treatment Studies
- Advanced Breast Cancer Therapies
- Cancer Treatment and Pharmacology
- HER2/EGFR in Cancer Research
- Animal Behavior and Reproduction
- Avian ecology and behavior
- Metastasis and carcinoma case studies
- Endometrial and Cervical Cancer Treatments
- Cancer Diagnosis and Treatment
- Ovarian cancer diagnosis and treatment
- Cancer Risks and Factors
- Coordination Chemistry and Organometallics
- Plant and animal studies
- Maternal and Perinatal Health Interventions
- Breast Lesions and Carcinomas
- BRCA gene mutations in cancer
- Endometriosis Research and Treatment
- Pregnancy and preeclampsia studies
- Cancer Research and Treatments
- Breast Implant and Reconstruction
- Wildlife Ecology and Conservation
- Assisted Reproductive Technology and Twin Pregnancy
- Prenatal Screening and Diagnostics
University Hospital Ulm
2016-2025
Universität Ulm
2014-2024
Olgahospital
2024
Klinik für Frauenheilkunde
2016-2024
Universitäts Frauenklinik
2013-2020
National Center for Tumor Diseases
2013-2019
University Medical Center Hamburg-Eppendorf
2013-2019
Universität Hamburg
1987-2019
Heinrich Heine University Düsseldorf
2013-2019
Heidelberg University
2013-2019
Circulating tumor cells (CTCs) have been shown to predict reduced survival outcomes in metastatic breast cancer.CTCs were analyzed 2026 patients with early cancer before adjuvant chemotherapy and 1492 after using the CellSearch System. After immuno-magnetic enrichment for expressing epithelial-cell adhesion molecule, CTCs defined as nucleated cytokeratin lacking CD45. The followed a median of 35 months (range = 0-54). Kaplan-Meier analyses log-rank test used analyses. All statistical tests...
Although unequivocal evidence has shown the prognostic relevance of circulating tumor cells (CTC) in peripheral blood patients with metastatic breast cancer, less is available for CTCs at time primary diagnosis.We conducted a pooled analysis individual data from 3,173 nonmetastatic (stage I-III) cancer five institutions. The prevalence and numbers were assessed diagnosis FDA-cleared CellSearch System (Janssen Diagnostics, LLC). Patient outcomes analyzed using meta-analytic procedures,...
Abstract Background The phenotypes of tumor cells change during disease progression, but invasive rebiopsies metastatic lesions are not always feasible. Here we aimed to determine whether initially HER2-negative breast cancer (MBC) patients with HER2-positive circulating (CTCs) benefit from a HER2-targeted therapy. Methods open-label, interventional randomized phase III clinical trial (EudraCT Number 2010-024238-46, CliniclTrials.gov Identifier: NCT01619111) recruited March 2012 until...
<h3>Importance</h3> Circulating tumor cells (CTCs) represent the liquid component of solid tumors and are a surrogate marker for residual cancer burden. Although CTC status is prognostic recurrence death in breast cancer, its role guiding clinical management remains unknown. <h3>Objective</h3> To determine whether predictive radiotherapeutic benefit early-stage cancer. <h3>Design, Setting, Participants</h3> The cohort studies present analysis included patients with stages pT1 to pT2 pN0 pN1...
The prognostic relevance of circulating tumor cells (CTCs) at the time primary diagnosis has been well established. However, little information is available regarding their to follow-up care.The multicenter, open-label, phase III SUCCESS A trial compared two adjuvant chemotherapy regimens followed by 2 vs 5 years zoledronate for early-stage, high-risk breast cancer patients. presence CTCs was assessed before and after using FDA-approved CellSearch System. Overall survival (OS) disease-free...
Obese breast cancer patients have worse prognosis than normal weight patients, but the level at which obesity is prognostically unfavorable unclear. This retrospective analysis was performed using data from SUCCESS A trial, in 3754 with high-risk early were randomized to anthracycline- and taxane-based chemotherapy or without gemcitabine. Patients classified as underweight/normal (body mass index (BMI) < 25.0), overweight (BMI 25.0–29.9), slightly obese 30.0–34.9), moderately 35.0–39.9)...
Abstract Background Circulating tumour cells (CTCs) are mainly enriched based on the epithelial cell adhesion molecule (EpCAM). Although it was shown that an EpCAM low-expressing CTC fraction is not captured by such approaches, knowledge about its prognostic and predictive relevance relation to EpCAM-positive CTCs lacking. Methods We developed immunomagnetic assay enrich from metastatic breast cancer patients independently using antibodies against Trop-2 CD-49f characterised their...
•Presence of CTCs in MBC is associated with worse clinical outcome.•About 15% patients HER2-negative harbor strong HER2 staining.•HER2 status predicts OS univariate but not multivariate analysis. BackgroundCirculating tumor cells (CTCs) have been reported to predict outcome metastatic breast cancer (MBC). Biology may differ from that the primary and HER2-positive are found some tumors.Patients methodsPatients were screened for participation DETECT III IV trials before initiation a new line...
Abstract Background Anthracycline/cyclophosphamide-taxane-containing chemotherapy (AC-T) is the standard of care in adjuvant treatment HER2-negative early breast cancer (EBC), but recent studies suggest omission anthracyclines for reduced toxicity without compromising efficacy. Methods Based on individual patient data ( n = 5924) pooled from randomised Phase III trials PlanB and SUCCESS C, we compared disease-free survival (DFS) overall (OS) between intermediate to high-risk EBC-patients...
Ovarian cancer is mostly associated with pathologically regulated permeability of peritoneal vessels, leading to ascites. Here, we investigated the molecular regulation endothelial by vascular growth factor (VEGF) and both tight adherens junction proteins (VE-cadherin claudin 5) regards tumor biology different ovarian types.Serum ascites samples before after surgery, as well biopsies 68 patients 20 healthy controls were collected. In serum VEGF protein was measured ELISA. co-localization...
<h3>Importance</h3> Bisphosphonate treatment in patients with early breast cancer has become part of care, but the optimal duration is still unclear. <h3>Objective</h3> To compare 2 vs 5 years zoledronate following adjuvant chemotherapy cancer. <h3>Design, Setting, and Participants</h3> The SUCCESS A phase 3 multicenter randomized open-label clinical trial a × factorial design enrolled 3754 from September 21, 2005, to March 12, 2007 (last patient out, May 7, 2014). Final data analysis was...
Objectives Triple-negative breast cancer (TNBC) requires chemotherapy-based systemic treatment which is usually anthracycline-based (AB). The cardiotoxicity of AB regimens especially relevant in the elderly population. Therefore, we retrospectively compared survival and toxicity between patients with early TNBC receiving or anthracycline-free (AF) adjuvant chemotherapy to evaluate whether could be spared anthracycline-related without compromising survival. Methods study population comprised...
Abstract Purpose: The aim of PREDICT was to confirm clinical validity and the potential for utility serial circulating tumor cell (CTC) enumeration in metastatic breast cancer (MBC) patients focusing on its prognostic value different subtypes settings. Experimental design: In total, 4436 individual patient-level data with CTC results from both baseline one follow-up (CellSearch®; Menarini Silicon Biosystems) were analyzed evaluate association between detection overall survival (OS) full...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRepresentative metalation and reduction reactions of the superactive metal hydrides, LiH, NaH, KHRafael Pi, Thomas Friedl, Paul v. R. Schleyer, Peter Klusener, Lambert BrandsmaCite this: J. Org. Chem. 1987, 52, 19, 4299–4303Publication Date (Print):September 1, 1987Publication History Published online1 May 2002Published inissue 1 September 1987https://doi.org/10.1021/jo00228a027RIGHTS & PERMISSIONSArticle Views1444Altmetric-Citations61LEARN ABOUT...
Alkali metal hydrides would be ideally suitable for the synthesis of carbanions , since only H 2 formed as second product; unfortunately, however, they are normally not very reactive. A LiH, NaH and KH by hydrogenation BuM (M = Li, Na, K) in hexane is now described here which leads to highly reactive hydrides. In addition, deprotonate more selectively than other metalation reagents.