A5080985755- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Mycobacterium research and diagnosis
- Diverticular Disease and Complications
- Genetic factors in colorectal cancer
- Gastrointestinal disorders and treatments
- Helicobacter pylori-related gastroenterology studies
- Gastroesophageal reflux and treatments
- Global Cancer Incidence and Screening
- Colorectal Cancer Surgical Treatments
- DNA Repair Mechanisms
- Radiomics and Machine Learning in Medical Imaging
- Pancreatic and Hepatic Oncology Research
- Carcinogens and Genotoxicity Assessment
- Monoclonal and Polyclonal Antibodies Research
- Toxin Mechanisms and Immunotoxins
- Viral gastroenteritis research and epidemiology
- Galectins and Cancer Biology
- CRISPR and Genetic Engineering
- Genetics and Neurodevelopmental Disorders
- Economic and Financial Impacts of Cancer
- Peptidase Inhibition and Analysis
Erasmus MC
2013-2024
Erasmus University Rotterdam
2011-2023
Rotterdam University of Applied Sciences
2012
University Medical Center Utrecht
2000-2006
Centre National de la Recherche Scientifique
1994
University of Sussex
1994
Inserm
1994
Istituto di Genetica Molecolare
1994
Laboratoire d'études sur les monothéismes
1994
<h3>Background:</h3> Screening for colorectal cancer (CRC) is widely accepted, but there no consensus on the preferred strategy. We conducted a randomised trial comparing participation and detection rates (DR) per screenee of guaiac-based faecal occult blood test (gFOBT), immunochemical FOBT (FIT), flexible sigmoidoscopy (FS) CRC screening. <h3>Methods:</h3> A representative sample Dutch population (n = 15 011), aged 50–74 years, was 1:1:1 prior to invitation one three screening strategies....
Immunochemical faecal occult blood testing (FIT) provides quantitative test results, which allows optimisation of the cut-off value for follow-up colonoscopy. We conducted a randomised population-based trial to determine characteristics FIT (OC-Sensor micro, Eiken, Japan) screening at different levels and compare these with guaiac-based (gFOBT) in an average risk population. A representative sample Dutch population (n=10 011), aged 50–74 years, was 1 : before invitation gFOBT screening....
Peginterferon alfa-2a results in a sustained response (SR) minority of patients with hepatitis B e antigen (HBeAg)–negative chronic (CHB). This study investigated the role early on-treatment serum surface (HBsAg) levels prediction SR HBeAg-negative receiving peginterferon alfa-2a. HBsAg (Architect from Abbott) was quantified at baseline and during treatment (weeks 4, 8, 12, 24, 36, 48) follow-up 60 72) sera 107 who participated an international multicenter trial (peginterferon alfa-2a, n =...
Nucleos(t)ide analogues strongly inhibit viral replication in chronic hepatitis B (CHB) infection, but knowledge of their long-term effect on serum surface antigen (HBsAg) levels and HBsAg loss is lacking. Seventy-five CHB patients with virological response (VR) to ETV or TDF were included. decline 2 years after VR was most pronounced HBeAg-positive patients. Age, alanine aminotransferase, HBeAg associated Predicted median time 36 for 39 HBeAg-negative Thus, treated will probably need...
<h3>Objective</h3> Colorectal cancer screening by means of faecal immunochemical tests (FITs) requires successive rounds for an optimal preventive effect. However, data on the influence length interval participation and diagnostic yield are lacking. Repeated FIT was therefore performed in a population-based trial comparing various repeat intervals. <h3>Design</h3> 7501 Dutch individuals aged 50–74 years were randomly selected invited two 1-sample (haemoglobin (Hb) concentration ≥50 ng/ml,...
Fecal immunochemical test (FIT) screening for colorectal cancer (CRC) requires timely successive rounds an optimal preventive effect. However, data on attendance and trend in yield over multiple of FIT are limited. We therefore conducted a consecutive third round population-based CRC trial.Average-risk subjects aged 50-74 years were approached three 1-sample (OC-sensor) screening. Subjects with hemoglobin level ≥50 ng/ml (≥10 μg Hb/g) feces referred colonoscopy. positive previous not...
To counteract the deleterious effects of DNA damage, a sophisticated network repair systems has evolved, which is essential for genetic stability and prevention carcinogenesis. Nucleotide excision (NER), one main pathways, can remove wide range lesions from by complex multistep reaction (for recent review, see Hoeijmakers 1993). Two subpathways are recognized in NER: rapid "transcription-coupled" less efficient global genome (Bohr 1991; Hanawalt Mellon The consequences inborn errors NER...
Hepatitis B e antigen (HBeAg)-negative chronic hepatitis patients are at high risk of treatment relapse after any antiviral therapy. Combining peginterferon alpha-2a with ribavirin might improve sustained response rates.Overall, 138 HBeAg-negative were randomized to receive monotherapy (peginterferon 180 microg weekly plus placebo) or combination therapy 1,000 1,200 mg daily, depending on body weight) for 48 weeks. Post-treatment follow-up lasted 24 Analyses based the modified...
Summary As chronic hepatitis C patients with progressive disease can present themselves normal ALT levels, more sensitive biomarkers are needed. Micro RNA s newly discovered small noncoding that stable and detectable in the circulation. We aimed to investigate association between hepatocyte‐derived micro serum liver injury . The mi R ‐122 ‐192 were analysed sera of 102 HCV ‐infected 24 healthy controls. Serum levels correlated strongly ( = 0.67 0.65, respectively, P < 0.001 for both)....
Hepatitis B virus (HBV) RNA in serum is a novel biomarker for intrahepatic HBV replication and treatment response. For its proper use, it essential to identify factors influencing level. Using rapid amplification of complimentary DNA (cDNA) ends (RACE) PCR technique (lower limit detection [LLD], 800 copies/mL [c/mL]), levels were measured samples 488 untreated individuals with chronic infection who eligible according currently used recommendations. We explored the association patient‐...
The sensitivity and specificity of a single faecal immunochemical test (FIT) are limited. performance FIT screening can be improved by increasing the frequency or providing more than one sample in each round. This study aimed to evaluate if two-sample is cost-effective compared with one-sample FIT.The MISCAN-colon microsimulation model was used estimate costs benefits strategies either screening. cut-off level varied between 50 200 ng haemoglobin/ml, schedule respect age range interval. In...
In 2014, the national population-based colorectal cancer (CRC) screening program was implemented in Netherlands. Biennial fecal immunochemical testing (FIT) for hemoglobin (Hb) is used at a cut-off of 47 µg Hb per gram feces. The CRC successfully started, with high participation rates and yield screening. Now that has reached steady state, there potential to further optimize program. Previous studies showed prior (f-Hb) concentrations just below FIT are associated higher risk detection...
At the same time that Helicobacter pylori prevalence is declining in Western countries, immigrants from developing countries with high H. have settled urban areas. Actual epidemiological data on a migrant community may help realizing more selective approach to assess pylori-related diseases. We aimed define as well risk groups for cohort of young women living multi-ethnic European city.We measured Immunoglobulin G (IgG) anti-H. and CagA-antibodies serum pregnant included population-based...
Backgrounds. The prevalence of Helicobacter pylori has been declining in the developed countries, as it incidence distal gastric carcinoma. Monitoring this decline and identifying populations not benefiting from is a fit task for public health authorities, with blood donors an obvious source sera. Materials methods. We tested 1550 randomly selected donors, spread over 5–10 year age cohorts, four regions southern half Netherlands, presence antibodies against H. CagA antigen. These were drawn...
<h3>Objective</h3> Colorectal cancer screening programmes are implemented worldwide; many based on faecal immunochemical testing (FIT). The aim of this study was to evaluate two frequently used FITs participation, usability, positivity rate and diagnostic yield in population-based FIT screening. <h3>Design</h3> Comparison performed a fourth round FIT-screening cohort. Randomly selected individuals aged 50–74 were invited for randomly allocated receive an OC -Sensor (Eiken, Japan) or occult...
Hepatitis B virus RNA (HBV-RNA) is a novel serum biomarker that correlates with transcription of intrahepatic covalently closed circular (cccDNA), which an important target for pegylated interferon (PEG-IFN) and therapies functional cure. We studied HBV-RNA kinetics following PEG-IFN treatment its potential role as predictor to response in HBeAg-negative chronic hepatitis (CHB) patients.HBV-RNA levels were measured 133 CHB patients treated international randomized controlled trial (PARC...
Abstract Tumor expression of immune co-inhibitory ligands, such as PD-L1 and Galectin-9, have potential prognostic value in Hepatocellular Carcinoma (HCC). Circulating levels these molecules, however, hardly been studied. This study aims to assess the significance circulating Galectin-9 patients with resected HCC, compare their intra-tumoral same molecules. Archived tissues stored peripheral blood samples from 81 who underwent HCC resection or liver transplantation, curative intent, were...
Fecal immunochemical tests (FIT) are preferred over guaiac-based fecal occult blood testing as colorectal cancer (CRC) screening tool. However, hemoglobin (Hb) degradation time may influence FIT outcome. We therefore evaluated the effect of sample return on performance characteristics in a population-based CRC trial.A representative random Dutch population (n=17,677), aged 50-74 years, was invited for (OC-Sensor Micro; cutoff ≥ 50 ng Hb/ml). Sample defined interval days between sampling and...
Chronic viral hepatitis B and C cause liver fibrosis, leading to cirrhosis. Fibrosis assessment is essential establish prognosis treatment indication. We compared seven non-invasive tests, separately in combination, chronic patients detect early stages of fibrosis according the Metavir score biopsy.Galactose methacetin breath tests (GBT MBT), biomarkers (hyaluronic acid (HA), aspartate aminotransferase platelet ratio index (APRI), FibroTest, Fib-4) transient elastography (TE) were evaluated...