A5057252292- Immunotherapy and Immune Responses
- RNA modifications and cancer
- Receptor Mechanisms and Signaling
- Cancer Research and Treatments
- Immune Cell Function and Interaction
- Chromosomal and Genetic Variations
- Yeasts and Rust Fungi Studies
- Toxin Mechanisms and Immunotoxins
- SARS-CoV-2 and COVID-19 Research
- Microtubule and mitosis dynamics
- PARP inhibition in cancer therapy
- Atherosclerosis and Cardiovascular Diseases
- Cancer Cells and Metastasis
- Genomics and Chromatin Dynamics
- Protein Hydrolysis and Bioactive Peptides
- Plant Disease Resistance and Genetics
- Biochemical Analysis and Sensing Techniques
- Advanced biosensing and bioanalysis techniques
- Sleep and Wakefulness Research
- Cell Adhesion Molecules Research
- Wnt/β-catenin signaling in development and cancer
- Complement system in diseases
- Hematopoietic Stem Cell Transplantation
- Biochemical effects in animals
- Memory and Neural Mechanisms
Zhejiang Hospital
2017-2023
State Key Laboratory of Medical Neurobiology
2021-2022
Huashan Hospital
2021-2022
Fudan University
2021-2022
Huazhong Agricultural University
2019-2021
Changsha University of Science and Technology
2020
Army Medical University
2004-2016
Dopamine (DA) level in the nucleus accumbens (NAc) is critical for reward and aversion encoding. DA released from ventral mesencephalon (VM) DAergic neurons increases excitability of VM-projecting D1-dopamine receptor-expressing medium spiny (D1-MSNs) NAc to enhance release augment rewards. However, how such a positive feedback loop regulated maintain homeostasis reward-aversion balance remains elusive. Here we report that pallidum (VP) projection D1-MSNs (D1NAc-VP) inhibited by rewarding...
The neocortical prefrontal memory engram generated during initial learning is critical for remote episodic storage, however, the nature of early cortical tagging remains unknown. Here we found that in mice, increased norepinephrine (NE) release from locus coeruleus (LC) to medial cortex (mPFC) contextual fear conditioning (CFC) was and which regulated by ventrolateral periaqueductal grey. β-Blocker infusion, or knockout β1-adrenergic receptor (β1-AR) mPFC, impaired storage CFC memory, could...
The function of centromere protein U (CENPU) gene in breast cancer has not been well understood. Therefore, we explored the expression profiles CENPU carcinoma to better understand functions this gene, as relationship between and prognosis patients. Our results indicate that was expressed at significantly higher levels cancerous tissues than normal tissues. Furthermore, correlated with many clinicopathological characteristics cancer. In addition, discovered high predicted poor patients...
Abstract Background The spike (S) protein is a major structural glycoprotein of coronavirus (CoV), the causal agent severe acute respiratory syndrome (SARS). S potent target for SARS-specific cell-mediated immune responses. However, mechanism CoV pathogenesis in SARS and role special CTLs virus clearance are still largely uncharacterized. Here, we describe study that leads to identification novel HLA-A*0201-restricted epitope from conserved regions protein. Results First, different SARS-CoV...
Lung cancer, which is the leading cause of cancer death worldwide, influenced by a wide variety environmental and genetic risk factors. The silent information regulator 1 (SIRT1) gene located on long arm chromosome 10 (10q21.3) has been shown to play crucial roles in lung development previous studies. In this study, we determined whether variation SIRT1 associated with Chinese population.The case-control study comprised 246 controls 257 non-small cell patients, comprising 79 squamous...
Centromere protein U (CENPU) is a novel transcriptional repressor that associated with different types of cancer. However, its function in breast cancer poorly understood. In the present study, it was identified CENPU highly expressed tissues compared expression normal (P=0.001). Furthermore, mRNA level tumors often elevated, matched adjacent tissue specimens dataset from The Cancer Genome Atlas database (n=106; P<0.001). To understand human carcinogenesis, effects on proliferation,...
Abstract Recent reports suggest that complement system contributes to allograft rejection. However, its underlying mechanism is poorly understood. Herein, we investigate the role of component 3 (C3) in a single MHC-II molecule mismatched murine model rejection using C3 deficient mice (C3 −/− ) as skin graft donors or recipients. Compared with +/+ B6 allografts, grafts dramatically prolonged survival H-2 bm12 recipients, indicating plays critical both Th17 cell infiltration and Th1/Th17...
Background: Sperm-associated antigen 1 (SPAG1) has been identified as a marker of pancreatic cancer progression and promoter cell motility; however, its role in breast is not completely understood. Methods: SPAG1 expression tissues normal was obtained from online databases. Knockdown function assays were designed conducted to verify the functional lines. Cell counting MTT used assess proliferation. flow cytometry assay for cycle phase arrest, fluorescence microscopy colony formation...
Lung adenocarcinoma, as a common histological type in lung cancer, the overall survival is very low, and prognosis poor because it difficult to find easily recurs. Therefore, this study aimed explore role of secreted protein beta-1,3-N-acetylglucosaminyltransferase 3 (B3GNT3) development adenocarcinoma evaluate its potential significance for early clinical biomarker screening.The mRNA expression profiles patients with normal controls were analyzed via The Cancer Genome Atlas (TCGA) database....