A5016897190- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Sirtuins and Resveratrol in Medicine
- Cancer Cells and Metastasis
- MicroRNA in disease regulation
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- Pneumonia and Respiratory Infections
- interferon and immune responses
- Anorectal Disease Treatments and Outcomes
- Atherosclerosis and Cardiovascular Diseases
- Tuberculosis Research and Epidemiology
- Pelvic floor disorders treatments
- Pelvic and Acetabular Injuries
- Chromosomal and Genetic Variations
- Wnt/β-catenin signaling in development and cancer
- Cell Adhesion Molecules Research
- Genomics and Chromatin Dynamics
- Toxin Mechanisms and Immunotoxins
- Cannabis and Cannabinoid Research
- Autophagy in Disease and Therapy
- PARP inhibition in cancer therapy
- Adipose Tissue and Metabolism
- Systemic Lupus Erythematosus Research
- Advanced biosensing and bioanalysis techniques
Sixth Affiliated Hospital of Sun Yat-sen University
2024
Foshan Maternity and Child Health Care Hospital
2024
Zhejiang Hospital
2015-2024
Sun Yat-sen University
2024
Zhejiang University
2012-2024
Children's Hospital of Zhejiang University
2024
The roles of Silent mating type information regulation 2 homolog 1 (SIRT1) and High mobility group A1 (HMGA1) in human diseases have been extensively studied separately; however, to the best our knowledge, current study is first report on their interrelationship lung cancer. association SIRT1 HMGA1 non-small cell cancer (NSCLC) was investigated by evaluating expression prognostic significance 260 patients with NSCLC using immunohistochemistry. were found be significantly correlated each...
The function of centromere protein U (CENPU) gene in breast cancer has not been well understood. Therefore, we explored the expression profiles CENPU carcinoma to better understand functions this gene, as relationship between and prognosis patients. Our results indicate that was expressed at significantly higher levels cancerous tissues than normal tissues. Furthermore, correlated with many clinicopathological characteristics cancer. In addition, discovered high predicted poor patients...
Tumor immune microenvironment (TIME) is crucial for tumor initiation, progression, and metastasis; however, its relationship with lung adenocarcinoma (LUAD) unknown. Traditional predictive models screen biomarkers that are too general infrequently associated genes.RNA sequencing data of LUAD patients immune-related gene sets were retrieved from public databases. Using the common genes shared by The Cancer Genome Atlas (TCGA) Immunology Database Analysis Portal (ImmPort), differential...
Triple-negative breast cancer (TNBC) is a subtype of with poor prognosis. Cancer-associated fibroblasts (CAFs) play critical role in regulating TNBC tumor development. This study aimed to identify and characterize specific CAFs associated TNBC. Initially, using high-throughput bulk transcriptomic data two cohorts, we identified three CAF-related subtypes (CS1, CS2, CS3) samples. These were closely linked the microenvironment. The CS1 exhibited relatively immune-rich microenvironment...
Lung cancer, which is the leading cause of cancer death worldwide, influenced by a wide variety environmental and genetic risk factors. The silent information regulator 1 (SIRT1) gene located on long arm chromosome 10 (10q21.3) has been shown to play crucial roles in lung development previous studies. In this study, we determined whether variation SIRT1 associated with Chinese population.The case-control study comprised 246 controls 257 non-small cell patients, comprising 79 squamous...
Genes encoding IRF1 and IRF8 protein have been proposed as candidate tuberculosis susceptibility genes. In order to elucidate whether the variants were associated with susceptibility, we conducted a case-control study consisting of 495 controls 452 ethnically matched cases in Chinese population. Seven haplotype tagging single-nucleotide polymorphisms (tagSNPs) (rs2057656; rs2706381; rs2070724; rs2070721; rs2549008; rs2549007; rs2706386) from HapMap database analyzed, which provided an almost...
Centromere protein U (CENPU) is a novel transcriptional repressor that associated with different types of cancer. However, its function in breast cancer poorly understood. In the present study, it was identified CENPU highly expressed tissues compared expression normal (P=0.001). Furthermore, mRNA level tumors often elevated, matched adjacent tissue specimens dataset from The Cancer Genome Atlas database (n=106; P<0.001). To understand human carcinogenesis, effects on proliferation,...
The mammalian Atg16L1 protein consists of a coiled-coil domain and tryptophan-aspartic acid (WD) repeat is involved in the process autophagy. However, mechanisms underlying effect isoforms on autophagy remain to be elucidated humans. In present study, we successfully cloned three isoforms: Atg16L1-1, which contains complete sequence; Atg16L1-2, lacks all exon 8; Atg16L1-3, domain. Subsequent experiments showed that were colocalised with MDC within cells. Quantitative analysis fluorescence...
Triple-negative breast cancer (TNBC) is an aggressive that affects about 13/100,000 women yearly. Patients with TNBC are often resistant to endocrine and molecular targeted therapy, making clinical treatment challenging. Researches indicate tumor microenvironment (TME) related prognosis in many cancers. Therefore, we aim identify TME immune-related biomarkers enhance the immunotherapy efficacy patients TNBC.The bulk mRNA transcriptome data information of (GSE58812) (GSE25055) datasets were...
Background: Sperm-associated antigen 1 (SPAG1) has been identified as a marker of pancreatic cancer progression and promoter cell motility; however, its role in breast is not completely understood. Methods: SPAG1 expression tissues normal was obtained from online databases. Knockdown function assays were designed conducted to verify the functional lines. Cell counting MTT used assess proliferation. flow cytometry assay for cycle phase arrest, fluorescence microscopy colony formation...
Total pelvic exenteration is the ultimate solution for rectovesicovaginal fistula caused by radiation therapy, yet total frequently causes intraoperative complications and postoperative complications. These are responsible dysfunction of lower extremities, impaired quality life, even high long-term morbidity rate, thus multidisciplinary cooperation early intervention prevention necessary. Physical therapy was found to reduce promote rehabilitation, effect on how physiotherapy prevents treats...