A5028128984- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Hernia repair and management
- Urological Disorders and Treatments
- Pediatric Urology and Nephrology Studies
- Cancer-related molecular mechanisms research
- Kidney Stones and Urolithiasis Treatments
- Urologic and reproductive health conditions
- Virus-based gene therapy research
- Ferroptosis and cancer prognosis
- Autophagy in Disease and Therapy
- Cancer, Lipids, and Metabolism
- Bladder and Urothelial Cancer Treatments
- Testicular diseases and treatments
- Pelvic floor disorders treatments
- Renal cell carcinoma treatment
- MicroRNA in disease regulation
- Minimally Invasive Surgical Techniques
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Enhanced Recovery After Surgery
- Tissue Engineering and Regenerative Medicine
- Urinary Bladder and Prostate Research
- Renal and Vascular Pathologies
- Abdominal Surgery and Complications
Sixth Affiliated Hospital of Sun Yat-sen University
2018-2025
Sun Yat-sen University
2016-2025
Fujian Academy of Agricultural Sciences
2025
Jinan University
2024
St Vincent's Hospital Sydney
2023
Concord Repatriation General Hospital
2021
Third Affiliated Hospital of Sun Yat-sen University
2010-2019
The First Affiliated Hospital, Sun Yat-sen University
2016
Guangzhou Medical University
2016
Duke University
2010
Abstract The epithelium, an essential barrier to protect organisms against infection, exists in many organs. However, rapid re‐epithelialization restore tissue integrity and function adverse environment is challenging. In this work, a long‐term anti‐inflammatory antioxidant hydrogel with mechanical stimulation for re‐epithelialization, mainly composed of the small molecule thioctic acid, biocompatible glycine, γ‐Fe 2 O 3 nanoparticles reported. Glycine‐modified supramolecular acid stable...
Chronic glomerulonephritis (CGN) is one of the major causes end-stage kidney disease. Zhen-wu-tang (ZWT), as a famous Chinese herbal prescription, widely used in China for CGN therapy clinic. However, mechanism ZWT has not been fully understood. The present study explored therapeutic effect and underlying on mitochondrial function cationic bovine serum albumin (C-BSA)-induced model rats tumor necrosis factor (TNF-α)-damaged mouse podocytes. renal functions were measured by creatinine (Scr)...
Accumulating investigations have demonstrated that microRNAs (miRNAs) are promising efficient targets for the next generation of molecular therapeutics.The development miRNA-based therapies requires identification and validation cancer-associated miRNAs.Herein, we identified miR-197-3p regulates carcinogenesis prostate cancer (PCa) via bioinformatics analysis.Next, investigated function regulatory mechanisms in PCa.Overexpression suppressed PCa cell proliferation colony formation.In...
Streptococcus suis (S. suis) is considered as one of the most crucial bacterial pathogens that leads to serious economic losses swine industry. Different S. serotypes exhibit diverse characteristics in population structure and pathogenicity. Epidemiology data underscore importance serotype 3 (SS3). However, except for a few epidemiological information, limited study information available on this serotype. Herein, pathogenic SS3 (the strain YA) was isolated from infected piglets clinical...
Abstract To identify independent risk factors for urosepsis in diabetic patients with upper urinary tract stones (UUTS) and develop a prediction model to facilitate early detection diagnosis, we retrospectively reviewed medical records of admitted between January 2020 June 2023. Patients were divided based on the quick Sequential Organ Failure Assessment (qSOFA) score. The least absolute shrinkage selection operator (LASSO) regression analysis was used variable form preliminary model....
Introduction: Circulating tumor cells (CTCs) are important prognostic indicators for malignancies. However, a reliable positive/negative cutoff value of non-epithelial (NE+: hybrid and mesenchymal) CTCs phenotype in prostate cancer (PCa) patients has not been established. Here, we aimed to determine the NE+ high-risk (HRPC) after radical prostatectomy (RP). Methods: The was established spiking experiments, were detected 208 HRPC using CanPatrolTM platform. expression function COL1A1 PCa...
Abstract Prostate cancer (PCa) is the most common malignant tumor in males, which frequently develops into castration‐resistant prostate (CRPC) with limited therapies. Gambogenic acid (GNA), a flavonoids compound isolated from Gamboge, exhibits anti‐tumor capacity various cancers. Our results showed that GNA revealed not only antiproliferative and pro‐apoptotic activities but also induction of autophagy PCa cells. In addition, inhibitor chloroquine enhanced pro‐apoptosis effect GNA....
Oncolytic virotherapy is a novel and emerging treatment modality that uses replication-competent viruses to destroy cancer cells. Although diverse cell types are sensitive oncolytic viruses, one of the major challenges sensitivity oncolysis ranges among different types. Furthermore, underlying mechanism action not fully understood. Here, we report activation cyclic adenosine monophosphate (cAMP) signaling significantly sensitizes refractory cells alphavirus M1 in vitro, vivo, ex vivo. We...
The role of cell division cycle 20 (CDC20) was investigated in chemoresistance to decetaxel and the underlying mechanisms metastatic castration-resistant prostate cancer (mCRPC). MTT assays were performed determine effects siRNA-mediated CDC20 knockdown on proliferation anticancer activity docetaxel. Western blot analyses conducted detect changes Akt Wnt signaling. Furthermore, vivo growth PCa examined nude mice treated with siCDC20 or docetaxel alone combination. overexpressed mCRPC cells....
PURPOSE: To compare the curative effects of ureteroscopic lithotripsy and laparoscopic ureterolithotomy for unilateral upper ureteral stones, to explore optimal surgical indications skills. METHODS: Fifty cases stones were randomly divided into two groups: one group underwent holmium laser under epidural or lumbar anesthesia (n=25), another general (n=25). Double-J stent was routinely indwelled in both groups. Operating time, postoperative hospitalization stone clearance rate perioperative...
The aim of this study is to evaluate the capacity polylactid acid (PLA) fibrous membrane seeded with allogeneic rabbit adipose tissue-derived stem cells (ADSCs) repair urethral defects in a model.Rabbit ADSCs were harvested and phenotypically characterized. Twenty-four New Zealand male rabbits 5-mm mucosal randomly divided into two groups. They underwent urethroplasty either PLA (group A) or blank B). At 4 6 weeks after urethroplasty, grafts collected analyzed grossly histologically....
Abstract Muscle-invasive bladder cancer (MIBC) is associated with low survival and high recurrence rates even in cases which patients receive systemic treatments, such as surgery chemotherapy. Here, we found that a naturally existing alphavirus, namely, M1, selectively kills cells but not normal cells, findings supported by our observations of changes viral replication MIBC patient-derived cell apoptosis. Transcriptome analysis revealed interferon-stimulated genes (ISGs) are expressed at...
Abstract: High-mobility group AT-hook 2 (HMGA2) is involved in a wide spectrum of biological processes and upregulated several tumors, but its role renal carcinoma remains unclear. The aim this study was to examine the expression HMGA2 relationship overall survival (OS) patients with non-metastatic clear cell (ccRCC) following surgery. evaluated retrospectively by immunohistochemistry (IHC) 162 ccRCC who underwent nephrectomy 2003 2004. An IHC analysis revealed that expressed nuclei tumor...
To evaluate the association between use of statins and/or metformin and patient survival in prostate cancer patients Taiwan.Newly diagnosed who had hyperlipidemia received radiotherapy were identified from National Health Insurance Research Database 2000-2010. The rate was estimated by Kaplan-Meier method. Univariate multivariate Cox regression analyses performed to examine mortality. Sensitivity analysis assess risk mortality with diabetes.The study included 567 patients. Patients used or...