A5065831759- Cellular Mechanics and Interactions
- Bone Metabolism and Diseases
- Force Microscopy Techniques and Applications
- 3D Printing in Biomedical Research
- Cell Adhesion Molecules Research
- Erythrocyte Function and Pathophysiology
- Microfluidic and Bio-sensing Technologies
- Silk-based biomaterials and applications
- Crystallization and Solubility Studies
- Higher Education and Teaching Methods
- X-ray Diffraction in Crystallography
- RNA regulation and disease
- Supercapacitor Materials and Fabrication
- Advanced Combustion Engine Technologies
- Blood properties and coagulation
- Innovative Educational Techniques
- EFL/ESL Teaching and Learning
- Invertebrate Immune Response Mechanisms
- Carbon Nanotubes in Composites
- Advancements in Battery Materials
- Elasticity and Material Modeling
- Second Language Learning and Teaching
- Combustion and flame dynamics
- Education and Work Dynamics
- Fibroblast Growth Factor Research
Changsha University of Science and Technology
2025
Huazhong University of Science and Technology
2021-2024
Union Hospital
2021-2024
Beihang University
2023-2024
North China University of Science and Technology
2024
Hunan University
2023
Southern University of Science and Technology
2020-2021
Stomatology Hospital
2020
Guangzhou Medical University
2020
National University of Defense Technology
2020
Yes-associated protein (YAP) is regulated by mechanical cues via the interaction of Hippo pathway with cytoskeleton. Previous studies showed that YAP plays a role in regulating actomyosin network suppressing Rho GTPase medaka fish. Here, we identify activating 29 (ARHGAP29) as transcriptional target human gastric cancer cell line. promotes expression ARHGAP29 to suppress RhoA-LIMK-cofilin pathway, destabilizing F-actin. The overexpression causes cytoskeletal rearrangement altering dynamics...
Osteoarthritis (OA) is a devastating whole-joint disease affecting large population worldwide with no cure; its mechanism remains poorly defined. Abnormal mechanical stress the main pathological factor of OA. To investigate effects Piezo1 activation on osteoarthritis development and progression to explore Piezo1-targeting OA treatment. The expression levels were determined in human cartilage experimental mice. Mice genetic deletion chondrocytes or intra-articular injection activator Yoda1...
Apoptosis is a mechanism of eliminating damaged or unnecessary cells during development and tissue homeostasis. During apoptosis within tissue, the adhesions between dying neighboring non-dying need to be remodeled so that apoptotic cell expelled. In parallel, contraction actomyosin cables formed in drives extrusion. To date, coordination dynamics adhesion progressive changes tension around an not fully understood. Live imaging histoblast expansion, which coordinated replacement process...
In vertebrates, the type 1 parathyroid hormone receptor (PTH1R) is a critical regulator of skeletal development and homeostasis; however, how it modulated incompletely understood. Here we report that deleting Kindlin-2 in osteoblastic cells using mouse 10-kb Dmp1-Cre largely neutralizes intermittent PTH-stimulated increasing bone volume fraction mineral density by impairing both osteoblast osteoclast formation murine adult bone. Single-cell profiling reveals loss increases proportion...
The role of osteocytes in maintaining bone mass has been progressively emphasized. Pip5k1c is the most critical isoform among PIP5KIs, which can regulate cytoskeleton, biomembrane, and Ca2+ release cells participate many processes, such as cell adhesion, differentiation, apoptosis. However, its expression function are still unclear. To determine osteocytes, was deleted by breeding 10-kb mouse Dmp1-Cre transgenic mice with Pip5k1cfl/fl mice. Bone histomorphometry, micro-computerized...
Alkali metal-ion capacitors (AMICs) combine the advantages of high specific energy alkali batteries (AMIBs) and power output supercapacitors (SCs), which are considered highly promising efficient storage devices. It is found that carbon has been most widely used electrode material AMICs due to its low cost, a large surface area, excellent electrical conductivity. However, application limited by capacity, finite kinetic performance, few active sites. Doping heteroatoms in materials an...
The key focal adhesion protein β1 integrin plays an essential role in early skeletal development. However, roles of expression osteocytes during the regulation bone homeostasis and mechanotransduction are incompletely understood. To study vivo function osteocyte bone, we utilized 10-kb Dmp1 (Dentin matrix acidic phosphoprotein 1)-Cre to generate mice with deletion this cell type. Micro-computerized tomography, histomorphometry immunohistochemistry were performed determine effects loss on...
Due to computational complexity of correlation searching, the digital image (DIC) method is often extremely time consuming in processing and optical measurement, which has limited its further applications a great extent. This paper develops fast recursive scheme mathematically reduce burden traditional DIC technique therefore improve efficiency deformation calculation. A global sum-table approach proposed simplify computations all double sums arising zero-normalized cross-correlation...
Influences of substrate stiffness on mechanical properties cardiac myocytes and fibroblasts were investigated by cell elasticity measurement with atomic force microscopy. The cells cultured collagen-coated polyacrylamide substrates gradient rigidity. While showed no evident change in different substrates, displayed the non-monotonic dependence a maximum elastic modulus. Moreover, was found to be regulated actin filaments. Study effect for provides new information better understanding...
Abstract Osteocytes act as mechanosensors in bone; however, the underlying mechanism remains poorly understood. Here we report that deleting Kindlin-2 osteocytes causes severe osteopenia and mechanical property defects weight-bearing long bones, but not non-weight-bearing calvariae. loss impairs skeletal responses to stimulation bones. Control cKO mice display similar bone induced by unloading. However, unlike control mice, fail restore lost after reloading. Osteocyte deletion focal adhesion...
Cell culture studies demonstrate the importance of β3 integrin in osteocyte mechanotransduction. However,
Cell-substrate interaction is implicated in many physiological processes. Dynamical monitoring of cellular tractions on substrate critical investigating a variety cell functions such as contraction, migration, and invasion. On account the inherent ill-posed property an inverse problem, traction recovery essentially sensitive to displacement noise thus likely produces unstable results. Therefore, some additional constraints must be applied obtain reliable estimate. By integrating classical...
In vertebrate,the nucleus pulposus (NP), which is an essential component of the intervertebral disc, constantly impacted by fluid shear stress (FSS); however, molecular mechanism(s) through FSS modulates NP homeostasis poorly understood. Here we show that regulates extracellular matrix (ECM) in cells. A moderate dose (i.e., 12 dyne/cm2) increases sulfated glycosaminoglycan (sGAG) content and protein levels Col2a1 Aggrecan decreases those metalloproteinase 13 (MMP13) a disintegrin with...
Background Precise incidence prediction of Hepatitis infectious disease is critical for early prevention and better government strategic planning. In this paper, we presented different models using deep learning methods based on the monthly through a national public health surveillance system in China mainland. Methods We assessed compared performance three methods, namely, Long Short-Term Memory (LSTM) model, Recurrent Neural Network (RNN) Back Propagation (BPNN) model. The data collected...