A5084108321- Nanoplatforms for cancer theranostics
- Colorectal Cancer Surgical Treatments
- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- Gastric Cancer Management and Outcomes
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Lymphadenopathy Diagnosis and Analysis
- Cancer, Lipids, and Metabolism
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Extracellular vesicles in disease
- Radiomics and Machine Learning in Medical Imaging
- Cardiac, Anesthesia and Surgical Outcomes
- Luminescence and Fluorescent Materials
- Photodynamic Therapy Research Studies
- Ferroptosis and cancer prognosis
- Esophageal and GI Pathology
- Circular RNAs in diseases
- Metastasis and carcinoma case studies
- Colorectal and Anal Carcinomas
- Diverticular Disease and Complications
- Cancer Cells and Metastasis
- Colorectal Cancer Treatments and Studies
- Molecular Biology Techniques and Applications
Southern University of Science and Technology
2019-2025
Jinan University
2015-2025
ShenZhen People’s Hospital
2002-2023
University of Hong Kong
2014
Sun Yat-sen University
2014
University of Hong Kong - Shenzhen Hospital
2014
Abstract The development of novel photosensitizing agents with aggregation‐induced emission (AIE) properties has fueled significant advances in the field photodynamic therapy (PDT). An electroporation method was used to prepare tumor‐exocytosed exosome/AIE luminogen (AIEgen) hybrid nanovesicles (DES) that could facilitate efficient tumor penetration. Dexamethasone then normalize vascular function within microenvironment (TME) reduce local hypoxia, thereby significantly enhancing PDT efficacy...
Abstract Metabolic interventions via targeting intratumoral dysregulated metabolism pathways have shown promise in reinvigorating antitumor immunity. However, approved small molecule immunomodulators often suffer from ineffective response rates and severe off‐target toxicity. ATP occupies a crucial role energy of components that form the tumor microenvironment (TME) influences cancer immunosurveillance. Here, nanocarrier‐assisted immunometabolic therapy strategy targets ATP‐adenosine axis...
While microRNAs (miRNAs) are known to play a critical role in the progression of colorectal cancer, miR-107 remains unknown. We evaluated its and explored underlying mechanism. MTT, wound-healing, transwell migration invasion assays were performed evaluate SW629 cell proliferation, invasion. Real time-PCR dual-luciferase reporter gene, TFR1 overexpression western blotting used explore MiR-107 is downregulated cancer tissues several human lines. Low expression often indicates poor survival...
Prostate cancer (PCa) is the second leading cause of death from in men. The mechanism underlying tumorigenesis and development PCa largely unknown. Here, we identified Kinesin family member 14 (KIF14) as a novel candidate oncogene PCa. We found that KIF14 was overexpressed multiple cell lines primary tissues. Knockdown DU145 PC3 prostate cells suppressed proliferation, induced cycle arrest apoptosis. Transcriptome analysis by RNA-sequencing demonstrated KIF4 suppression led to...
Increasing attention has been focused on cell type proteome profiling for understanding the heterogeneous multicellular microenvironment in tissue samples. However, current methods need large amounts of starting materials which preclude their application to clinical tumor specimens with limited access. Here, by seamlessly combining laser capture microdissection and integrated proteomics sample preparation technology SISPROT, specific types samples could be precisely dissected single...
Cell-free DNA (cfDNA) in plasma has emerged as a potential important biomarker clinical diagnostics, particularly cancer. However, somatic mutations are also commonly found healthy individuals, which interfere with the effectiveness for cancer diagnostics. This study examined background white blood cells (WBC) and cfDNA controls based on sequencing data from 821 non-cancer individuals several samples aim of understanding patterns detected cfDNA. We determined mutation allele frequencies both...
Abstract Long noncoding RNAs (lncRNA) have been demonstrated to extensively participate in a wide spectrum of biological activities ranging from embryogenesis and cancer progression. HOX transcript antisense RNA (Hotair), an lncRNA located the HOXC locus, has reported play important role carcinogenesis. As well‐known oncogene, it potentiates metastasis tumor And also serves as biomarker for poor prognosis recurrence. In this study, Hotair was found be upregulated colorectal (CRC) cells...
Postoperative monitoring for patients with colorectal cancer (CRC) requires sensitive biomarkers that are associated medical response and adjuvant therapy following surgery. Conventional tumor [including carcinoembryonic antigen (CEA), CA19‑9 CA125] widely used, but none of the markers provide high sensitivity or specificity. Previous studies indicated circulating DNA (ctDNA) is useful postoperative cancer. However, majority previous involved lung cancer, therefore further required which...
Abstract Background The identification of novel functional biomarkers is essential for recognizing high-risk patients, predicting recurrence, and searching appropriate treatment. However, no prognostic biomarker has been applied colorectal cancer (CRC) in the clinic. Methods Integrated with transcriptomic data from public databases, multi-omics examinations were conducted to search CRC. Moreover, potential biological functions regulatory mechanism these predictive genes also explored....
Colorectal cancer (CRC) is one of the most commonly diagnosed cancers with high mortality rate due to its poor diagnosis in early stage. Here, we report a urinary metabolomic study on cohort CRC patients ( <math xmlns="http://www.w3.org/1998/Math/MathML" id="M1"> <mi>n</mi> </math> =67) and healthy controls id="M2"> =21) using ultraperformance liquid chromatography triple quadrupole mass spectrometry. Pathway analysis showed that series pathways belong amino acid metabolism, carbohydrate...
The restriction of a tumor's energy supply is proven to be an effective means treatment. Glucose oxidase (GOx), enzyme that catalyzes the conversion glucose glucolactone, producing oxygen and hydrogen peroxide in process, has proved useful this regard. However, hypoxia, which implicated tumor growth, been found mediate resistance type starvation. Here, we describe design testing platelet membrane mimetic, PMS, consisting mesoporous silica nanoparticles (MSNs) loaded with metformin (MET) as...
Circulating tumor DNA (ctDNA) has been recognized as a promising biomarker for colorectal cancer (CRC) early diagnosis and postoperative monitoring. However, we hypothesize that the clinical value of ctDNA sequencing may differ colon (CC) rectal (RC).Forty-three patients with primary CRC were prospectively enrolled. Tumor tissue samples, paired preoperative plasma samples series obtained. Mutations in each sample identified compared.For 73.0% patients, at least one concordant mutation was...
Abstract Previous studies have suggested that Bcl2-associated athanogene 2 (BAG2) serves as a crucial regulator for tumorigenesis in multiple tumors. However, little is known about the effect of BAG2 on esophageal squamous cell carcinoma (ESCC). This study focused investigating whether functions cancer-promoting gene ESCC. In this work, expression data and clinical information from NCBI Gene Expression Omnibus (GEO), Oncomine The Cancer Genome Atlas (TCGA) were collected analyzed. ESCC was...