A5013269651- Pancreatitis Pathology and Treatment
- Pancreatic and Hepatic Oncology Research
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Gastrointestinal disorders and treatments
- Gastric Cancer Management and Outcomes
- Esophageal and GI Pathology
- Gallbladder and Bile Duct Disorders
- Circular RNAs in diseases
- Psoriasis: Treatment and Pathogenesis
- Case Reports on Hematomas
- Colorectal Cancer Screening and Detection
- Intraperitoneal and Appendiceal Malignancies
- Esophageal Cancer Research and Treatment
- Immune Response and Inflammation
- RNA modifications and cancer
- Mycobacterium research and diagnosis
- Diverticular Disease and Complications
- Abdominal Trauma and Injuries
- Gut microbiota and health
- Liver Disease Diagnosis and Treatment
- Gout, Hyperuricemia, Uric Acid
- Phagocytosis and Immune Regulation
- Autophagy in Disease and Therapy
- Appendicitis Diagnosis and Management
Jinan University
2016-2025
Shenzhen Second People's Hospital
2019-2025
Southern University of Science and Technology
2019-2024
Shenyang University
2024
ShenZhen People’s Hospital
2015-2020
Second Military Medical University
2018
Shanghai Pudong New Area Gongli Hospital
2018
Second Hospital of Shandong University
2015
Baicalin is a bioactive ingredient extracted from the root of Scutellariae radix, which used to treat ulcerative colitis (UC).We investigated activity baicalin on lipopolysaccharide-stimulated RAW264.7 cells and 2,4,6-trinitrobenzene sulfonic acid-induced rats, including attenuation oxidant stress apoptosis.The severity was assessed by disease index. The activities catalase (CAT), glutathione peroxidase (GSH-PX), superoxide dismutase (SOD), content malondialdehyde (MDA) were determined their...
MicroRNA-34a (miR-34a) is a direct transcriptional target of p53, and downregulated in several different types cancer. However, the underlying mechanism miR-34a effects colorectal cancer not well understood. In this study, we explored role cell invasion, migration, apoptosis. Transient overexpression SW480 cells caused severe decrease migration invasion (both, p<0.05) compared to control groups. Combining transfection with 5-fluorouracil (5-FU) treatment further enhanced inhibition 5-FU...
Abstract In most solid tumors, cellular energy metabolism is primarily dominated by aerobic glycolysis, which fulfills the high demand for biomacromolecules at expense of reduced ATP production efficiency. Elucidation mechanisms rapidly proliferating malignant cells acquire sufficient in this state inefficient from glycolysis could enable development targeted therapeutic strategies. study, we observed a significant association between elevated expression levels long non-coding RNA (lncRNA)...
<p>Supplementary Figure1</p>
<p>Supplementary Figure3</p>
<p>Supplementary Figure6</p>
<p>Supplementary Figure2</p>
<div>Abstract<p>In most solid tumors, cellular energy metabolism is primarily dominated by aerobic glycolysis, which fulfills the high demand for biomacromolecules at expense of reduced ATP production efficiency. Elucidation mechanisms rapidly proliferating malignant cells acquire sufficient in this state inefficient from glycolysis could enable development metabolism-targeted therapeutic strategies. In study, we observed a significant association between elevated expression...
<p>Supplementary Figure5</p>
<p>Supplementary Figure4</p>
<p>Supplementary Data</p>
Background Chronic pancreatitis (CP) is a chronic inflammatory disease of the pancreas. This study aimed to compare natural course alcoholic (ACP) and idiopathic (ICP). Methods CP patients admitted our center from January 2000 December 2013 were enrolled. Characteristics compared between ACP ICP patients. Cumulative rates diabetes mellitus (DM), steatorrhea, pancreatic stone, pseudocyst, biliary stricture, cancer after onset diagnosis calculated, respectively. The cumulative DM steatorrhea...
Curcumin has a therapeutic effect on ulcerative colitis, but the underlying mechanism yet to be elucidated. The aim of present study was clarify possible mechanisms. Dextran sulfate sodium‑induced colitis mice were treated with curcumin via gavage for 7 days. effects disease activity index (DAI) and pathological changes colonic tissue in determined. Interleukin (IL)‑6, IL‑10, IL‑17 IL‑23 expression levels measured by ELISA. Flow cytometry used detect ratio mouse spleen regulatory T cells...
Long non-coding RNA (lncRNA) LINC00460 is an onco-lncRNA in a variety of cancers, including pancreatic cancer (PC). This study aimed to investigate the regulatory mechanisms PC.The tumor and adjacent normal tissues were collected from 73 PC patients. The expression LINC00460, miR-503-5p, ANLN was detected using qRT-PCR. We then analyzed proliferation, migration, invasion, apoptosis/cell cycle cells by performing MTT/EdU, transwell, flow cytometry assays, respectively. xenograft model...
Immunogenic cell death (ICD) promotes the immune antitumor response via releasing damage-associated molecular patterns (DAMPs) from dying tumor cells. The induction of autophagy improves efficacy multiple immunogenic chemotherapies. Here, we show that piceatannol, a dietary phenolic compound is widely distributed in fruits and vegetables such as grapes, blueberries, mushrooms, induces enhances oxaliplatin (OXA)-induced anticancer response. Specifically, piceatannol enhanced OXA-induced...
Epigallocatechin-3-gallate (EGCG) has a promising therapeutic effect for ulcerative colitis (UC), but the treatment mechanism yet to be fully elucidated. The aim of present study was investigate EGCG in UC. Experimental mouse models were prepared. mice randomly divided into four groups: Normal control, model (MD), 50 mg/kg/day and 100 treatment. daily disease activity index (DAI) recorded, changes organizational structure colon observed spleen (SI) measured. In addition, levels interleukin...
MicroRNAs (miRNAs) are reported to play critical roles in various cancers. Recently, mounting miRNAs found exert oncogenic or tumor inhibitory role gastric cancer (GC), however, their potential molecular mechanism GC remains ill-defined. Currently, we aimed elucidate the functional and mechanistic impacts of a novel miRNA on cellular process. The significant down-regulation miR-876-5p cells attracted our attention. In function, performed gain-of-function assays that overexpression repressed...
Background: MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) play vital regulatory roles in pancreatic cancer (PC) initiation progression. We aimed to explore the biological functions underlying mechanisms of miR-505-3p (miR-505) PC. Methods: first screened miRNA expression profiles using microarray PC tissues normal tissues, then studied function mechanism miR-505. Moreover, we evaluated effect lncRNA LINC01448 on Results: demonstrated miR-505 that was significantly downregulated...
The disorder of lipid metabolism and genetic predisposition are major risk factors for coronary artery disease (CAD). Variants in the apolipoprotein A1 (APOA1) gene play an important role regulation lipids. objective present study was to investigate effect two polymorphisms (-75 G/A +83 C/T) APOA1 on profiles CAD.A total number 300 subjects with CAD age sex matched healthy controls were enrolled study. Genotyping performed by polymerase chain reaction-restriction fragment length polymorphism...
The aim of this study was to evaluate the effect a simple visceral obesity phenotype, known as hypertriglyceridemic waist phenotype and its quantitative indicator circumference index on severity acute pancreatitis. Diagnosis analysis pancreatitis were determined according Atlanta classification guidelines, revised in 2012. We considered characterized by increased elevated triglyceride concentrations. investigated association between including index. significantly associated with systemic...
Abstract Background and Aim Diabetes mellitus (DM) is a common complication of idiopathic chronic pancreatitis (ICP), which impairs the quality life for patients. This study aimed to identify risk factors develop nomogram DM in ICP help early diagnosis. Methods Idiopathic patients admitted our center from January 2000 December 2013 were included. Cumulative rates calculated by Kaplan–Meier method. Patients randomly assigned, 2:1 ratio, training validation cohort. Based on cohort, identified...
Pancreatic cancer with about 5% five-year overall survival rate remains a challenge. Invasion and migration of pancreatic cells are the main factors leading to poor prognosis. MicroRNA-490-5p (miR-490-5p) has anti-cancer effects in variety tumors, but its role not been reported. The mRNA expressions miR-490-5p, MAGI2 antisense RNA 3 (MAGI2-AS3), Matrix metalloproteinase (MMP)2, MMP9, N-cadherin, E-cadherin were detected by quantitative real-time PCR, while protein these genes except...