A5101636281- Psoriasis: Treatment and Pathogenesis
- Cancer-related molecular mechanisms research
- Immune cells in cancer
- IL-33, ST2, and ILC Pathways
- MicroRNA in disease regulation
- Mycobacterium research and diagnosis
- Gastrointestinal disorders and treatments
- Flavonoids in Medical Research
- Phytochemistry and Biological Activities
- Natural product bioactivities and synthesis
- RNA Research and Splicing
- Glycosylation and Glycoproteins Research
- Nonlocal and gradient elasticity in micro/nano structures
- Burn Injury Management and Outcomes
- Ion Channels and Receptors
- Skin and Cellular Biology Research
- Effects of Radiation Exposure
- Cytokine Signaling Pathways and Interactions
- Extracellular vesicles in disease
- Cancer Immunotherapy and Biomarkers
- Lymphoma Diagnosis and Treatment
- Composite Structure Analysis and Optimization
- Circular RNAs in diseases
- Advanced Materials and Mechanics
- Bacteriophages and microbial interactions
Yili Normal University
2024
Pudong New Area People's Hospital
2023
Jinan University
2015-2022
Shenzhen Second People's Hospital
2019-2022
Zero to Three
2015
XinHua Hospital
2009
Curcumin has a therapeutic effect on ulcerative colitis, but the underlying mechanism yet to be elucidated. The aim of present study was clarify possible mechanisms. Dextran sulfate sodium‑induced colitis mice were treated with curcumin via gavage for 7 days. effects disease activity index (DAI) and pathological changes colonic tissue in determined. Interleukin (IL)‑6, IL‑10, IL‑17 IL‑23 expression levels measured by ELISA. Flow cytometry used detect ratio mouse spleen regulatory T cells...
Small nucleolar RNA host gene 15 (SNHG15) plays an oncogenic role in many cancers. However, the of SNHG15 bladder cancer (BLCA) remains unclear. In this study, regulation on activities BLCA cells (T24 and RT112) was investigated. detail, super-enhancers (SEs), differentially expressed genes, functional enrichment were detected by bioinformatic analyses. Mutant cell lines lacking SNHG15-SEs established using CRISPR-Cas9. Relative expression quantitative polymerase chain reaction (qPCR),...
Long non-coding RNA (lncRNA) LINC00460 is an onco-lncRNA in a variety of cancers, including pancreatic cancer (PC). This study aimed to investigate the regulatory mechanisms PC.The tumor and adjacent normal tissues were collected from 73 PC patients. The expression LINC00460, miR-503-5p, ANLN was detected using qRT-PCR. We then analyzed proliferation, migration, invasion, apoptosis/cell cycle cells by performing MTT/EdU, transwell, flow cytometry assays, respectively. xenograft model...
Ulcerative colitis (UC) is a chronic inflammatory bowel disease suggested to be closely related the imbalance of regulatory T cell/T helper 17 cell (Treg/Th17) signaling. Previously, we constructed an interleukin-10 (IL-10) expression vector, BL-hIL-10, and proved that it ameliorates dextran sulfate sodium-induced intestinal inflammation in mice. In this study, further explored mechanisms underlying BL-hIL-10 treatment from Treg/Th17 perspective. Our results showed oral administration...
Activity of bc1 complex kinase (ABC1K) is an atypical protein (aPK) that plays a crucial role in plant mitochondrial or plastid stress responses, but little known about the responses ABC1Ks to cotton (Gossypium spp.). Here, we verified 40 upland hirsutum L.) and found GhABC1Ks were unevenly distributed across 17 chromosomes. GhABC1K family members contained 35 paralogous gene pairs expanded by segmental duplication. The promoter sequences diversified cis-acting regulatory elements relevant...
Abstract The present study aims to reveal the detailed molecular mechanism of microRNA (miR)-802 in progression inflammatory bowel disease (IBD). IBD tissues were obtained from patients, followed by CD4+ cells isolation. Then, qRT-PCR and ELISA used detect expression miR-802, suppressor cytokine signaling 5 (SOCS5), interleukin (IL)-17A tumor necrosis factor (TNF)-α. Transfection miR-802 mimics inhibitor was detected Western blot. TargetScan luciferase reporter assay relationship between...
Objective Inflammatory bowel disease (IBD) is a chronic intestinal disease. This study was attempted to investigate the effects of long noncoding RNA KIF9-AS1 (KIF9-AS1) on development IBD and its underlying mechanism action. Methods Quantitative real time PCR (qRT-PCR) implemented examine expression microRNA-148a-3p (miR-148a-3p). The mouse model induced by dextran sulfate sodium (DSS). body weight, activity index (DAI) score, colon length histological injury were used evaluate injury....
Over the past years, only few cases of follicular lymphoma diagnosed by laparoscopy have been reported in world. Since related ascites often causes occult disease and lacks specific clinical manifestations, it is difficult to identify cause routine laboratory tests imaging methods. Diagnostic experience not sufficient more need be accumulated for further analysis.Ascites due unknown reasons problems diagnosis treatment. In this paper, we report one case with whom reason causing was...
Objective To construct and identify a novel IL-10 delivery system by transforming hIL-10-containing plasmid into B.longum(BL-hIL-10). Methods A vector pBADs-GFP was selected which had been built previous test biosynthetic hIL-10 plasmid, through double enzyme digestion reaction,to PBADs-hIL-10 shuttle then to synthesis BL-hIL-10. expressed secreted the culture supernatant of BL-hIL-10 after 0.2%L-arabinose induction in vitro as examined Western blot, enzyme-linked immunosorbent...
Objective To perform a DNA-based prenatal diagnosis in family with recessive dys-trophic epidermolysis bullosa, and to develop strategy eliminate maternal cell contamination amniotic fluid samples. Methods Amniocentesis was carried out at gestation week 16, culture used separate fetal cells from blood cells. Peripheral obtained the proband, her parents. Genomic DNA extracted peripheral aminotic Subsequently, PCR direct sequencing were performed detect pathogenic mutations COL7A1 gene....