A5014829233- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Peptidase Inhibition and Analysis
- Pediatric Hepatobiliary Diseases and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Colorectal Cancer Screening and Detection
- Neuroendocrine Tumor Research Advances
- Gastrointestinal disorders and treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Epigenetics and DNA Methylation
- Soft tissue tumor case studies
- Oral and Maxillofacial Pathology
- Gallbladder and Bile Duct Disorders
- Long-Term Effects of COVID-19
- Phagocytosis and Immune Regulation
- Therapeutic Uses of Natural Elements
- Ion Channels and Receptors
- Ocular Diseases and Behçet’s Syndrome
- Endodontics and Root Canal Treatments
- Helicobacter pylori-related gastroenterology studies
- Microbial Metabolites in Food Biotechnology
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Ferroptosis and cancer prognosis
- Pain Management and Opioid Use
- Burn Injury Management and Outcomes
Changhai Hospital
2018-2025
Second Military Medical University
2018-2025
Huashan Hospital
2023
Fudan University
2023
Shanghai Institute of Hematology
2022
China Association for Science and Technology
2020
Shanghai Association for Science and Technology
2020
Abstract Background Since the coronavirus disease 2019 (COVID-19) outbreak, many COVID-19 variants have emerged, causing several waves of pandemics and infections. Long COVID-19, or long-term sequelae after recovery from has aroused worldwide concern because it reduces patient quality life rehabilitation. We aimed to characterize functional differential profile oral gut microbiomes serum metabolites in patients with gastrointestinal symptoms associated long COVID-19. Methods prospectively...
Abstract Autoimmune pancreatitis (AIP) is identified as a severe chronic immune‐related disorder in pancreas, including two subtypes. In this study, pancreatic lesions patients diagnosed either type 1 AIP or 2 are examined, and these patients’ peripheral blood at single‐cell level. Furthermore, flow cytometry, immunofluorescence, functional assays performed to verify the cell AIP, there notable increase amount of B cells plasma cells, IgG4+ key pathogenic AIP. The differentiation path...
Background & AimsMutations in the trypsinogen gene (PRSS1) cause human hereditary pancreatitis. However, it is not clear how mutant forms of PRSS1 contribute to disease development. We studied effects expressing mice.MethodsWe expressed with and without mutation encoding R122H (PRSS1R122H) specifically pancreatic acinar cells under control a full-length elastase promoter. Mice that did express these transgenes were used as controls. given injections caerulein induce acute pancreatitis or...
EUS-guided tissue acquisition (EUS-TA) is the preferred method to acquire pancreatic cancer (PC) tissues. The factors associated with false-negative outcomes and inadequate samples should be explored gain an understanding of EUS-TA.
Acute pancreatitis is a common critical and acute gastrointestinal disease worldwide, with an increasing percentage of morbidity. However, the gene expression pattern in peripheral blood has not been fully analyzed. In addition, mechanism coronavirus 2019 (COVID-19)-induced investigated. Here, after bioinformatic analysis machine-learning methods data cells validation local patients, two functional modules were identified, S100A6, S100A9, S100A12 validated as predictors severe pancreatitis....
Background. With the progress of precision medicine treatment in pancreatic ductal adenocarcinoma (PDAC), individualized cancer-related medical examination and prediction are great importance this high malignant tumor tumor-immune microenvironment with changed pathways highly enrolled carcinogenesis PDAC. Methods. High-throughput data were downloaded from Gene Expression Omnibus (GEO) The Cancer Genome Atlas (TCGA) database. After batch normalization, enrichment pathway relevant scores...
Enteropeptidase (EP) is a type II transmembrane serine protease and physiological activator of trypsinogen. Extensive studies related to EP have been conducted date. However, no bibliometric analysis has systematically investigated this theme. Our study aimed visualize the current landscape frontier trends scientific achievements on EP, provide an overview past 120 years insights for researchers clinicians facilitate future collaborative research clinical intervention.Quantitative...
Abstract Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the main types malignant tumor digestive system, and patient prognosis affected by difficulties in early diagnosis, poor treatment response, a high postoperative recurrence rate. Carbohydrate antigen 19-9 (CA19-9) has been widely used as biomarker for diagnosis follow-up PDAC patients. Nevertheless, production mechanism potential role CA19-9 progression have not yet elucidated. Methods: We performed single-cell RNA...
Validation of serum tumor biomarkers in predicting advanced cystic mucinous neoplasm the pancreas
Abstract Background Intraductal papillary mucinous neoplasms (IPMNs) and cystic (MCNs) represent the tumors with malignant transformation potential. The objective of study was to verify their pathological characteristics, prognoses, recurrence factors. Methods Two hundred eighteen IPMNs 27 MCNs resected at a single institution were included. demographic, preoperative, histopathological, follow-up data patients recorded analyzed. Overall survival (OS) disease-free (DFS) defined as interval...
Cathepsin B (CTSB) is a lysosomal protease implicated in the progression of various diseases. A large number CTSB-related studies have been conducted to date. However, there no comprehensive bibliometric analysis on this subject. In our study, we performed quantitative publications retrieved from Science Citation Index Expanded (SCIE) Web Core Collection (reference period: 2011-2021). total 3,062 original articles and reviews were retrieved. The largest USA (n = 847, 27.66%). research output...
With the progress of precision medicine treatment in pancreatic ductal adenocarcinoma (PDAC), individualized cancer-related examination and prediction is great importance this high malignant tumor, antibody-dependent cell phagocytosis (ADCP) with changed pathways highly enrolled carcinogenesis PDAC. High-throughput data were downloaded 160 differentially expressed ADCP-related genes (ARGs) obtained. Secondly, GO KEGG enrichment analyses show that ADCP a pivotal biologic process...
(A) CS powders were used to prepare the ion solution. (B) Chronic pancreatitis was treated by administering solution via tail vein injection.
Abstract Background and Aim The European evidence‐based guidelines (EEG) American College of Gastroenterology Guidelines (ACGG) have been published to guide the management pancreatic cystic lesions. We aim evaluate value both in predicting advanced lesions (A‐PCLs) with preoperatively imaging‐suspected mucinous neoplasms (cMNs). Methods One hundred ninety‐eight patients who underwent resections from 2013 2019 for suspected cMNs were retrospectively reviewed. Receiver operating characteristic...
Replacement of the exocrine parenchyma by fibrous tissue is a main characteristic chronic pancreatitis. Understanding mechanisms pancreatic fibrogenesis critical for development preventive and therapeutic interventions. Cyclooxygenase-2 (COX-2), rate-limiting enzyme prostaglandin synthesis, expressed in patients with However, it unknown whether COX-2 can cause To investigate roles acinar pancreatitis, was ectopically specifically cells transgenic mice. Histopathological changes expression...
Background: Calcium silicate biomaterials (CSB) have witnessed rapid development in the past 30 years. This study aimed to accomplish a comprehensive bibliometric analysis of published research literature on CSB for biomedical applications and explore hotspot current status. Methods: Articles related last three decades (1990-2020) were retrieved from Web Science Core Collection. The R bibliometrix package VOSviewer used construct publication outputs collaborative networking among authors,...
Endoscopic retrograde cholangiopancreatography (ERCP) for patients with periampullary diverticulum (PAD) remains a challenge. This study aims to investigate the factors and techniques related successful safe ERCP in PAD.We enrolled who underwent large tertiary center. The difficult cannulation rate, technical success clinical adverse events (AEs) rate were compared between or without PAD. Three independent logistic regression models established identify associated cannulation, success,...
Abstract Enteropeptidase (EP) initiates intestinal digestion by proteolytically processing trypsinogen, generating catalytically active trypsin. EP dysfunction causes a series of pancreatic diseases including acute necrotizing pancreatitis. However, the molecular mechanisms activation and substrate recognition remain elusive, due to lack structural information on heavy chain. Here, we report cryo-EM structures human in inactive, active, substrate-bound states at resolutions from 2.7 4.9 Å....