A5072472322- Microbial Metabolites in Food Biotechnology
- Metabolomics and Mass Spectrometry Studies
- Peptidase Inhibition and Analysis
- Natural product bioactivities and synthesis
- Polysaccharides and Plant Cell Walls
- Traditional Chinese Medicine Analysis
- Medicinal Plants and Bioactive Compounds
- Phytochemicals and Antioxidant Activities
- Polysaccharides Composition and Applications
- Phytochemistry and Biological Activities
- Plant biochemistry and biosynthesis
- Fermentation and Sensory Analysis
- Galectins and Cancer Biology
- Remote Sensing in Agriculture
- Traditional Chinese Medicine Studies
- Infant Nutrition and Health
- Advanced biosensing and bioanalysis techniques
- Plant Toxicity and Pharmacological Properties
- Gut microbiota and health
- Molecular Sensors and Ion Detection
- Sesquiterpenes and Asteraceae Studies
- Biochemical Analysis and Sensing Techniques
- Seaweed-derived Bioactive Compounds
- Endodontics and Root Canal Treatments
- Soil and Environmental Studies
Lanzhou University
2010-2024
Changhai Hospital
2022
Second Military Medical University
2022
Shanghai Institute of Hematology
2022
Abstract Owing to the increasing market demand of Codonopsis Radix, cropper blindly cultivates expand planting area for economic benefits, which seriously affects quality Radix. Therefore, this study synthesized 207 batches Radix and 115 ecological factors, analyzed suitable areas pilosula under current future climate change based on Geographic Information System (GIS) MaxEnt model. Secondly, we evaluated all-in-one functional factor including chromatographic fingerprint, index components,...
Codonopsis pilosula oligosaccharides (CPOs) showed promising anti-obesity effects in HFD-induced obese mice.
Biogenic amines (BA) are hazardous components in Huangjiu (HJ). To ensure the quality of Dangshen (DSHJ), an orthogonal experiment L
Codonopsis Radix, a popular food homology medicine, is widely used in clinical traditional Chinese medicine and supplement, raw products three types of processed are the main forms decoction pieces China. However, there no scientific basis for comprehensive chemical characterization products. Herein, we investigated qualitatively quantificationally secondary primary metabolites Radix by metabolomics glycomics employing multiple chromatography-mass spectrometry technology combined with...
Enteropeptidase (EP) is a type II transmembrane serine protease and physiological activator of trypsinogen. Extensive studies related to EP have been conducted date. However, no bibliometric analysis has systematically investigated this theme. Our study aimed visualize the current landscape frontier trends scientific achievements on EP, provide an overview past 120 years insights for researchers clinicians facilitate future collaborative research clinical intervention.Quantitative...
Cathepsin B (CTSB) is a lysosomal protease implicated in the progression of various diseases. A large number CTSB-related studies have been conducted to date. However, there no comprehensive bibliometric analysis on this subject. In our study, we performed quantitative publications retrieved from Science Citation Index Expanded (SCIE) Web Core Collection (reference period: 2011-2021). total 3,062 original articles and reviews were retrieved. The largest USA (n = 847, 27.66%). research output...
Blood deficiency model of mice was copied by subcutaneous injection with 200, 100 and mg x kg(-1) (0.01 mL g(-1)) acetyl phenylhydrazine (APH) at the frist, fourth, seventh days. Mice in each group were perfused different extracted parts Angelica sinensis (drug dosage 2.4 g kg(-1)) tenth day, once a day for 10 Then compare influence to RBC, Hb, PLT thymus, spleen weight changes blood mice. The peak areas common from HPLC fingerprint associated date replenishing pharmacodynamics efficacy...
Background: Calcium silicate biomaterials (CSB) have witnessed rapid development in the past 30 years. This study aimed to accomplish a comprehensive bibliometric analysis of published research literature on CSB for biomedical applications and explore hotspot current status. Methods: Articles related last three decades (1990-2020) were retrieved from Web Science Core Collection. The R bibliometrix package VOSviewer used construct publication outputs collaborative networking among authors,...
A simple and accurate high-performance liquid chromatography (HPLC) coupled with diode array detector (DAD) evaporative light scattering (ELSD) was established for the determination of six bioactive compounds in Zhenqi Fuzheng preparation (ZFP). The monitoring wavelengths were 254, 275 328 nm. Under optimum conditions, good separation achieved, assay fully validated respect precision, repeatability accuracy. proposed method successfully applied to quantify ingredients 31 batches ZFP samples...
Abstract A simple and sensitive high performance liquid chromatographic (HPLC) method for simultaneous determination of costunolide dehydrocostuslactone in mice plasma tissues was developed validated. Costunolide were extracted into acetonitrile separated using an isocratic mobile phase, on a Hypersil ODS C18 column. The effluent monitored by UV detector at 210 nm flow rate 1.0 mL· min −1 25°C. linearity ranges proposed 0.223–8.920 µg·mL 0.227–9.080 dehydrocostuslactone. intra‐day inter‐day...
Abstract Introduction Codonopsis Radix is a beneficial traditional Chinese medicine, and triterpenoid are the major bioactive constituents. pilosula var. modesta (Nannf.) L.T.Shen (CPM) precious variety of Radix, which distributed at high mountain areas. The environment plays an important role in synthesis metabolism active ingredients medicinal plants, but there no report elaborating on effect altitude terpenoid metabolites accumulation CPM. Objectives This study aims to analyse effects...
Abstract BACKGROUND Codonopsis pilosula var. modesta (CPVM) is a famous medicinal and edible plant of Campanulaceae. However, fresh CPVM roots (FCPVR) are prone to softening, browning spoilage after concentrated harvesting in the main production area Gansu Province, China autumn, which poses great challenges their large‐scale storage modern processing. In this study, effects chitosan (CS), natamycin (NA) modified atmosphere agent (MA) on postharvest quality FCPVR were first investigated. The...
Abstract Enteropeptidase (EP) initiates intestinal digestion by proteolytically processing trypsinogen, generating catalytically active trypsin. EP dysfunction causes a series of pancreatic diseases including acute necrotizing pancreatitis. However, the molecular mechanisms activation and substrate recognition remain elusive, due to lack structural information on heavy chain. Here, we report cryo-EM structures human in inactive, active, substrate-bound states at resolutions from 2.7 4.9 Å....
<title>Abstract</title> <bold>Background: </bold><italic>Codonopsis Radix </italic>is a benefit Traditional Chinese Medicine and triterpenoid are the major bioactive constituents of <italic>Codonopsis </italic>Radix. pilosula</italic>. var. <italic>modesta</italic>(Nannf.) L.T. Shen (CPM)is precious variety legal source Radix</italic>, it roots known as Wen Dangshen, which is distribute in high mountains area altitudes ranging from 1300 to 4300 m. Environment plays an important role...
Abstract The enteropeptidase (EP) initiates the intestinal digestion by proteolytic processing of trypsinogen, generating catalytic active trypsin. dysfunction EP will cause a series pancreatic diseases, most severe which is acute necrotizing pancreatitis. However, molecular mechanism activation and substrate recognition remain elusive due to lack structural information, hampering structure-based research even further EP-targeted drug design. Here we report cryo-EM structures human in...
Abstract The enteropeptidase (EP) initiates the intestinal digestion by proteolytic processing of trypsinogen, generating catalytic active trypsin. dysfunction EP will cause a series pancreatic diseases, most severe which is acute necrotizing pancreatitis. However, molecular mechanism activation and substrate recognition remain elusive due to lack structural information, hampering structure-based research even further EP-targeted drug design. Here we report cryo-EM structures human in...
CPP has been widely concerned for its immunocompetence. In this study, CPPs were prepared from 40 batches of Codonopsis pilosula 3 varieties in 4 provinces by water extraction and alcohol precipitation method. HPGPC, GC FT-IR fingerprints constructed. After the transmittance fingerprint was converted into absorbance, FT-IR, HPGPC fused at a low level to form multiple-fingerprint. Multiple-fingerprint combined with chemometrics methods showed that polysaccharides C.pilosula, C.pilosula var....