A5013395321- Traditional Chinese Medicine Analysis
- Natural product bioactivities and synthesis
- Chromatography in Natural Products
- Polysaccharides and Plant Cell Walls
- Flavonoids in Medical Research
- Phytochemistry and Biological Activities
- Medicinal Plant Pharmacodynamics Research
- Analytical Chemistry and Chromatography
- Traditional Chinese Medicine Studies
- Pharmacological Effects of Natural Compounds
- Polysaccharides Composition and Applications
- Plant-based Medicinal Research
- Seaweed-derived Bioactive Compounds
- Advanced Nanomaterials in Catalysis
- Gold and Silver Nanoparticles Synthesis and Applications
- Food Quality and Safety Studies
- Metabolomics and Mass Spectrometry Studies
- Phytochemistry and biological activity of medicinal plants
- Advanced biosensing and bioanalysis techniques
- Ginseng Biological Effects and Applications
- Nanoparticles: synthesis and applications
- Phytochemical Studies and Bioactivities
- Bioactive Compounds and Antitumor Agents
- Fungal Biology and Applications
- Essential Oils and Antimicrobial Activity
Lanzhou University
2012-2022
Lanzhou City University
2011-2019
Institute of Pharmacology
2012-2013
Tashkent Pharmaceutical Institute
2012
Gansu University of Traditional Chinese Medicine
2010-2011
First Hospital of Lanzhou University
2010
The potential anti-gastric ulcer effects of Hedysarum polysaccharides (HPS-50 and HPS-80) were explored in rats.
<italic>Hedysarum</italic> polysaccharides extracted by a method involving extraction combined with modification had strong immunomodulatory effect, especially HPS-MC (80%).
Hedysarum polybotrys polysaccharide (HPS) is the principal active fraction responsible for antidiabetic properties of this species. The aim study was to determine 4 purified fractions different molecular weight range HPSs (HPS1, HPS2, HPS3, HPS4). HPS3 selected examination its hypoglycemic mechanism because significant effect in alloxan-induced diabetic mice. changes blood glucose levels and oral tolerance tests (OGTT) showed that hypoglycemia more pronounced HPS3-treated groups than...
The traditional Chinese medicine of Radix Hedysari plays an important role in invigorating gas for ascending, benefiting blood promoting production fluid, and circulation removing obstruction collaterals, which is consistent with the principle treatment osteoporosis. This study designed to investigate bioactive components on increasing peak bone mass (PBM) by exploring spectrum-effect relationship between chromatography fingerprints effect. Multiple indicators are selected evaluate...
The purpose of this study was to compare the effects different chromatographic columns for separation seven flavonoids. Four stationary phases are available, including bridged ethyl hybrid, BEH and same hybrid phase modified with 2-ethylpyridine, CSH fluorophenyl, HSS C18 SB. analytes included calycosin, genistein, medicarpin, calycosin-7-O-β-d-glucoside, formononetin, formononetin-7-O-β-d-glucoside, liquiritigenin. fluorophenyl column determined be most suitable provided fastest within 17...
Abstract Costunolide and dehydrocostuslactone are well‐known sesquiterpene lactones contained in many plants used as popular herbs, such Saussurea lappa Laurus novocanariensis , have been considered potential candidates for the treatment of various types tumor. In present work, a sensitive UPLC‐MS/MS quantification costunolide biological matrices has developed. The method is based on protein precipitation with acetonitrile followed by isocratic ultraperformance liquid chromatographic...
The spectrum-effect relationship on anti-hepatic fibrosis effect of Radix Hedysari was explored based high performance liquid chromatographic technique. Hepatic induced in mice by administering a subcutaneous injection carbon tetrachloride-peanut oil (4:6, v/v) continuously for 35 d at interval 5 (0.1 mL/10 g). And the same time modeling, different extracts were administered orally once daily dose 10 g/kg. ethanol extract specified to be most effective determining levels alanine...
Schematic diagram of the synthesis and application RH–AgNPs.
AbstractA water-soluble polysaccharide (HPS3aS) with a molecular mass of 1.22 × 104 Da was isolated from Hedysarum polybotrys using anion-exchange and gel-permeation chromatography. HPS3aS exhibits globular-shaped conformation in 0.1 M NaNO3 by size exclusion chromatography multi-angle laser light scattering (SEC-MALLS). The investigation the structural features this heteropolysaccharide through combination chemical instrumental analyses revealed that backbone is composed α-d-(1 → 4)-linked...
ABSTRACT Pteryxin is a coumarin compound naturally occurring in the roots of Radix Peucedani, commonly used as traditional Chinese medicine for treatment certain respiratory diseases and hypertension. An UPLC‐MS/MS method was established to quantify pteryxin mouse plasma tissue homogenates. Isoimperatorin internal standard (IS). The based on protein precipitation with methanol sample preparation. IS were separated using UPLC™ BEH C 18 column eluted mobile phase consisting water (70:30, v/v)...
An approach was proposed to evaluate preparation technology by means of fingerprint-peak matching high Performance liquid chromatography with diode array detector (HPLC-DAD). Similarity and hierarchical clustering analysis (HCA) were applied identify the 15 batches Xiaochaihu granules from different manufacturers our laboratory, peak pattern between composite formulae Radix Bupleuri Chinensis, which one main ingredients granules, utilized via indexes relative deviation retention time (RT) UV...
The crude Hedysarum polysaccharides (HPS: HPS-50 and HPS-80) obtained from Radix Hedysari exhibited great pharmacological activities in our previous research. This study investigated the effects of HPS on lipopolysaccharide (LPS)/D-galactosamine (D-GalN)-induced acute liver injury (ALI) mice LPS-induced LO2 cells, as well relationship between structural characteristics hepatoprotective activities. vivo results showed that compared with HPS-80, stronger hepatoprotection, which improved...